FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3177705088> ?p ?o ?g. }

• W3177705088 abstract "Abstract Background: Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease that often progresses to end-stage liver disease and/or the development of hepatobiliary neoplasia. Lack of prognostic tools and treatment options for PSC is driven in part by our poor understanding of its pathogenesis, which is thought to be complex, the interaction of genetic variants, environmental influences and biological response throughout the course of disease. The PSC Scientific Community Resource (PSC-SCR) seeks to overcome previous shortcomings by facilitating novel research in PSC with the ultimate goals of individualizing patient care and improving patient outcomes. Methods : PSC patients who receive their health care at Mayo Clinic or a collaborating site are identified by chart review and invited in person or by mail to participate. Non-Mayo patients are offered enrollment if they provide sufficient access to their medical records to evaluate inclusion/exclusion criteria. Controls without liver disease are identified with assistance of the Mayo Clinic Biobank. Participant consent is obtained at the beginning of the recruitment process by mail-in, electronic or face-to-face protocols. Clinical data is extracted from the medical record by qualified physicians and entered in a custom designed database. Participants fill out a custom-designed, comprehensive questionnaire, which collects scientifically relevant demographic and clinical information. Biospecimens are collected using mail-in kitsthar are returned via overnight carrier service and processed by the biospecimen accessioning and processing facility at Mayo Clinic, which coordinates sample transfers and provides required sample preparation services.The resource is currently being utilized to perform omics-scale projects investigating the exposome, metabolome, methylome, immunome and microbiome in PSC. Datasets and residual biospecimens will be shared with researchers proposing scientifically sound PSC-focused research with approval of the appropriate review boards. Discussion :Patient-based studies leveraging the latest technologies for targeted and wide-scale interrogation of multiple omics layers offer promise to accelerate PSC research through discovery of unappreciated aspects of disease pathogenesis. However, the rarity of PSC severely limits such studies. Here we describe our effort to overcome this limitation, the PSC-SCR, a repository of patient biospecimens coupled with clinical and omics data for use by the broader PSC research community." @default.
• W3177705088 created "2021-07-19" @default.
• W3177705088 creator A5015154136 @default.
• W3177705088 creator A5016619083 @default.
• W3177705088 creator A5021364484 @default.
• W3177705088 creator A5038589760 @default.
• W3177705088 creator A5045845228 @default.
• W3177705088 creator A5066362162 @default.
• W3177705088 creator A5083967141 @default.
• W3177705088 date "2021-07-06" @default.
• W3177705088 modified "2023-09-26" @default.
• W3177705088 title "PSC Scientific Community Resource The PSC Scientific Community Resource: An Asset for Multi-Omics Interrogation of Primary Sclerosing Cholangitis" @default.
• W3177705088 doi "https://doi.org/10.21203/rs.3.rs-629232/v1" @default.
• W3177705088 hasPublicationYear "2021" @default.
• W3177705088 type Work @default.
• W3177705088 sameAs 3177705088 @default.
• W3177705088 citedByCount "0" @default.
• W3177705088 crossrefType "posted-content" @default.
• W3177705088 hasAuthorship W3177705088A5015154136 @default.
• W3177705088 hasAuthorship W3177705088A5016619083 @default.
• W3177705088 hasAuthorship W3177705088A5021364484 @default.
• W3177705088 hasAuthorship W3177705088A5038589760 @default.
• W3177705088 hasAuthorship W3177705088A5045845228 @default.
• W3177705088 hasAuthorship W3177705088A5066362162 @default.
• W3177705088 hasAuthorship W3177705088A5083967141 @default.
• W3177705088 hasBestOaLocation W31777050881 @default.
• W3177705088 hasConcept C116567970 @default.
• W3177705088 hasConcept C126322002 @default.
• W3177705088 hasConcept C142724271 @default.
• W3177705088 hasConcept C195910791 @default.
• W3177705088 hasConcept C206345919 @default.
• W3177705088 hasConcept C2777075537 @default.
• W3177705088 hasConcept C2779134260 @default.
• W3177705088 hasConcept C2780615123 @default.
• W3177705088 hasConcept C31258907 @default.
• W3177705088 hasConcept C41008148 @default.
• W3177705088 hasConcept C512399662 @default.
• W3177705088 hasConcept C60644358 @default.
• W3177705088 hasConcept C71924100 @default.
• W3177705088 hasConcept C86803240 @default.
• W3177705088 hasConceptScore W3177705088C116567970 @default.
• W3177705088 hasConceptScore W3177705088C126322002 @default.
• W3177705088 hasConceptScore W3177705088C142724271 @default.
• W3177705088 hasConceptScore W3177705088C195910791 @default.
• W3177705088 hasConceptScore W3177705088C206345919 @default.
• W3177705088 hasConceptScore W3177705088C2777075537 @default.
• W3177705088 hasConceptScore W3177705088C2779134260 @default.
• W3177705088 hasConceptScore W3177705088C2780615123 @default.
• W3177705088 hasConceptScore W3177705088C31258907 @default.
• W3177705088 hasConceptScore W3177705088C41008148 @default.
• W3177705088 hasConceptScore W3177705088C512399662 @default.
• W3177705088 hasConceptScore W3177705088C60644358 @default.
• W3177705088 hasConceptScore W3177705088C71924100 @default.
• W3177705088 hasConceptScore W3177705088C86803240 @default.
• W3177705088 hasLocation W31777050881 @default.
• W3177705088 hasOpenAccess W3177705088 @default.
• W3177705088 hasPrimaryLocation W31777050881 @default.
• W3177705088 hasRelatedWork W2082482010 @default.
• W3177705088 hasRelatedWork W2108725499 @default.
• W3177705088 hasRelatedWork W2257083003 @default.
• W3177705088 hasRelatedWork W2945459308 @default.
• W3177705088 hasRelatedWork W3110868006 @default.
• W3177705088 hasRelatedWork W3157980915 @default.
• W3177705088 hasRelatedWork W3202918297 @default.
• W3177705088 hasRelatedWork W3206545407 @default.
• W3177705088 hasRelatedWork W4295242092 @default.
• W3177705088 hasRelatedWork W4295249455 @default.
• W3177705088 isParatext "false" @default.
• W3177705088 isRetracted "false" @default.
• W3177705088 magId "3177705088" @default.
• W3177705088 workType "article" @default.