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• W3177727892 abstract "Obesity and insulin resistance are associated with alterations in nitric oxide level and insulin secretion. Previous studies demonstrated that cinnamaldehyde (CNMA) improved islet insulin secretion and restored nitric oxide (NO) level, but its underlying mechanisms have not been investigated. This study aimed to investigate the effect of CNMA on inducible nitric oxide synthase (iNOS) activity and NO-induced islet insulin secretion in high-fat-diet (HFD) treated rats.Forty male Wistar rats (12 weeks old) were randomly divided into four equal groups, namely, control, CNMA, HFD, and HFD + CNMA. Control and CNMA groups were treated with standard laboratory animals' diet, while HFD and HDF + CNMA groups were fed with an HFD diet enriched with 25% W/W tail fat for 16 weeks. CNMA was administrated orally (20 mg/kg body weight, daily) during the study period. Islet insulin secretion and the inducible NOS activity in the presence or absence of L-NAME (NO synthase inhibitor, 5 mmol/L) were evaluated.L-NAME-suppressed insulin secretion in control, HFD, and HFD + CNMA groups; however, in the CNMA group, it could not exhibit such effect (P < 0.01). Islets of HFD-treated animals showed significantly higher iNOS activity than controls. CNMA treatment significantly suppressed iNOS activities in CNMA and HFD + CNMA groups compared with control and HFD, respectively.These results suggest that the beneficial effect of CNMA on insulin secretion might be due to its inhibitory effect on iNOS activity." @default.
• W3177727892 created "2021-07-19" @default.
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• W3177727892 date "2021-07-13" @default.
• W3177727892 modified "2023-09-26" @default.
• W3177727892 title "The Effect of Cinnamaldehyde on iNOS Activity and NO-Induced Islet Insulin Secretion in High-Fat-Diet Rats" @default.
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• W3177727892 doi "https://doi.org/10.1155/2021/9970678" @default.
• W3177727892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8292039" @default.
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• W3177727892 hasPublicationYear "2021" @default.
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