FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3177843313> ?p ?o ?g. }

• W3177843313 endingPage "121" @default.
• W3177843313 startingPage "116" @default.
• W3177843313 abstract "• Serum dickkopf-1 levels are substantially elevated after aSAH. • Serum dickkopf-1 levels are tightly correlated with hemorrhagic severity of aSAH. • Serum dickkopf-1 levels are independently related to 3-month prognosis after aSAH. • Serum dickkopf-1 levels efficiently distinguish a poor outcome after aSAH. Wnt signaling pathway is involved in early brain injury after aneurysmal subarachnoid hemorrhage (aSAH). Dickkopf-1 acts as a secreted Wnt antagonist. We analyzed the relationship between dickkopf-1 concentrations and clinical outcomes of aSAH. Serum dickkopf-1 concentrations were determined in 132 aSAH patients and 100 control individuals using the enzyme-linked immunosorbent assay. patients' characteristics, the World Federation of Neurological Surgeons (WFNS) Scale and modified Fisher grade were assessed. At 3-month follow-up, functional outcome (Glasgow Outcome Scale score; dichotomized as poor [score 1–3] or good [score 4–5]) was recorded. The multivariate logistic regression model was constructed to discern the association of serum dickkopf-1 concentrations with outcome. Compared with controls, serum dickkopf-1 concentrations were substantially raised after aSAH. Dickkopf-1 concentrations were highly related to WFNS score and modified Fisher score. Patients with a poor outcome had significantly increased dickkopf-1 concentrations. In multivariate logistic regression analysis, serum dickkopf-1 appeared as an independent predictor of poor outcome. Receiver operating characteristic curve analysis showed that serum dickkopf-1 concentrations predicted poor outcome efficiently. Serum dickkopf-1 concentrations were strongly associated with the severity and poor outcome of aSAH, suggesting that serum dickkopf-1 may be a novel biomarker for predicting poor outcome in aSAH." @default.
• W3177843313 created "2021-07-19" @default.
• W3177843313 creator A5003985309 @default.
• W3177843313 creator A5006769756 @default.
• W3177843313 creator A5036968274 @default.
• W3177843313 creator A5064911097 @default.
• W3177843313 creator A5084494635 @default.
• W3177843313 date "2021-10-01" @default.
• W3177843313 modified "2023-10-17" @default.
• W3177843313 title "Emerging role of serum dickkopf-1 in prognosis of aneurysmal subarachnoid hemorrhage" @default.
• W3177843313 cites W1564357553 @default.
• W3177843313 cites W1582482188 @default.
• W3177843313 cites W1874700596 @default.
• W3177843313 cites W1967073403 @default.
• W3177843313 cites W1990800915 @default.
• W3177843313 cites W2015656201 @default.
• W3177843313 cites W2019258749 @default.
• W3177843313 cites W2088436698 @default.
• W3177843313 cites W2121493719 @default.
• W3177843313 cites W2169920861 @default.
• W3177843313 cites W2513117707 @default.
• W3177843313 cites W2518785051 @default.
• W3177843313 cites W2579294647 @default.
• W3177843313 cites W2909112927 @default.
• W3177843313 cites W2943444690 @default.
• W3177843313 cites W2946956306 @default.
• W3177843313 cites W2994423232 @default.
• W3177843313 cites W2995377176 @default.
• W3177843313 cites W3019268992 @default.
• W3177843313 cites W3033985034 @default.
• W3177843313 doi "https://doi.org/10.1016/j.cca.2021.07.009" @default.
• W3177843313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34252424" @default.
• W3177843313 hasPublicationYear "2021" @default.
• W3177843313 type Work @default.
• W3177843313 sameAs 3177843313 @default.
• W3177843313 citedByCount "1" @default.
• W3177843313 countsByYear W31778433132023 @default.
• W3177843313 crossrefType "journal-article" @default.
• W3177843313 hasAuthorship W3177843313A5003985309 @default.
• W3177843313 hasAuthorship W3177843313A5006769756 @default.
• W3177843313 hasAuthorship W3177843313A5036968274 @default.
• W3177843313 hasAuthorship W3177843313A5064911097 @default.
• W3177843313 hasAuthorship W3177843313A5084494635 @default.
• W3177843313 hasConcept C126322002 @default.
• W3177843313 hasConcept C141071460 @default.
• W3177843313 hasConcept C151956035 @default.
• W3177843313 hasConcept C17624336 @default.
• W3177843313 hasConcept C2777736543 @default.
• W3177843313 hasConcept C2777796830 @default.
• W3177843313 hasConcept C2781197716 @default.
• W3177843313 hasConcept C55493867 @default.
• W3177843313 hasConcept C71924100 @default.
• W3177843313 hasConcept C86803240 @default.
• W3177843313 hasConcept C90924648 @default.
• W3177843313 hasConceptScore W3177843313C126322002 @default.
• W3177843313 hasConceptScore W3177843313C141071460 @default.
• W3177843313 hasConceptScore W3177843313C151956035 @default.
• W3177843313 hasConceptScore W3177843313C17624336 @default.
• W3177843313 hasConceptScore W3177843313C2777736543 @default.
• W3177843313 hasConceptScore W3177843313C2777796830 @default.
• W3177843313 hasConceptScore W3177843313C2781197716 @default.
• W3177843313 hasConceptScore W3177843313C55493867 @default.
• W3177843313 hasConceptScore W3177843313C71924100 @default.
• W3177843313 hasConceptScore W3177843313C86803240 @default.
• W3177843313 hasConceptScore W3177843313C90924648 @default.
• W3177843313 hasLocation W31778433131 @default.
• W3177843313 hasOpenAccess W3177843313 @default.
• W3177843313 hasPrimaryLocation W31778433131 @default.
• W3177843313 hasRelatedWork W2085810835 @default.
• W3177843313 hasRelatedWork W2142813572 @default.
• W3177843313 hasRelatedWork W2586834090 @default.
• W3177843313 hasRelatedWork W2743461267 @default.
• W3177843313 hasRelatedWork W2800983877 @default.
• W3177843313 hasRelatedWork W2887234945 @default.
• W3177843313 hasRelatedWork W2943444690 @default.
• W3177843313 hasRelatedWork W3128234143 @default.
• W3177843313 hasRelatedWork W4296378841 @default.
• W3177843313 hasRelatedWork W4315796434 @default.
• W3177843313 hasVolume "521" @default.
• W3177843313 isParatext "false" @default.
• W3177843313 isRetracted "false" @default.
• W3177843313 magId "3177843313" @default.
• W3177843313 workType "article" @default.