Matches in SemOpenAlex for { <https://semopenalex.org/work/W3177896031> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3177896031 abstract "Abstract Introduction: The emergence of HIV-1 recombinant forms and Drug combined antiretroviral therapy (cART) resistance are frequent in the therapeutic course of HIV-infected children in Low and Middle-Income Countries (LMIC) precisely in Central African Republic (CAR) as evidenced by studies carried out in the Bangui capital. Vertical transmission rate including during breastfeeding is 12.4. The aim of study is to analyze retrospectively the molecular characterization of sequencing results and mutation detected in HIV infected children who have received cART initiated since infancy. Methods: The 2019 retrospective review of the clinical, therapeutical, and immunological-molecular records of six children who were performed the genome sequencing, followed in Bouar, at the St Michel IST and HIV Center, in the north-west of the CAR. These children infected with HIV perinatally had their seropositive test performed at a median age of 6 years and initiated cARTs at an average age of 7 years as part of treatment regimens also used for the prevention of vertical transmission and the initiation of treatment for HIV infection in CAR. Results: We analyzed results from viral RNA extracted amplification and sequencing of 6 children plasma samples collected under first line antiretroviral therapy. Persistent opportunist infections confirmed Immunosuppression in all patients. Sequencing of viral genomes revealed high level resistance mutations to NRTIs (ABC, FTC and 3TC) in five patients and to NNRTIs (EFV, NVP used locally and DOR, ETR and RPV unused) for all with ambiguous positions in amino-acids comparison and deletion. The HIV-1 group M found in these patients were sub-type A (1) and G-J (1), and CRF02_AG (4), respectively. Three CRF02_AG strains formed a variant cluster by strongly detaching from other CAR and worldwide strains with robust boostrap at 91. Retention and adherence were complicated by the cART limited number and laboratory tests, the irregular supply, and the remoteness of patients from the Center. Conclusions: The genomes sequencing showed that resistance mutations made the treatment inefficient confirming the observed virological and immunological failure. The CRF02_AG genotype is an emerging variant, probably of foreign origin. This discovery clearly highlights the importance and the necessity of ART genetic resistance testing and personalized medicine." @default.
- W3177896031 created "2021-07-19" @default.
- W3177896031 creator A5025988336 @default.
- W3177896031 creator A5029853553 @default.
- W3177896031 creator A5045337979 @default.
- W3177896031 creator A5046389789 @default.
- W3177896031 creator A5059841476 @default.
- W3177896031 creator A5068249788 @default.
- W3177896031 creator A5080580164 @default.
- W3177896031 creator A5081099555 @default.
- W3177896031 creator A5086171339 @default.
- W3177896031 date "2021-07-08" @default.
- W3177896031 modified "2023-09-27" @default.
- W3177896031 title "High Resistance Mutation To cART In HIV-1 Exposed Infected Children And Recent Emergence Of CRF02_AG Variant In Bouar, A Rural Environment of Central African Republic" @default.
- W3177896031 doi "https://doi.org/10.21203/rs.3.rs-660796/v1" @default.
- W3177896031 hasPublicationYear "2021" @default.
- W3177896031 type Work @default.
- W3177896031 sameAs 3177896031 @default.
- W3177896031 citedByCount "0" @default.
- W3177896031 crossrefType "posted-content" @default.
- W3177896031 hasAuthorship W3177896031A5025988336 @default.
- W3177896031 hasAuthorship W3177896031A5029853553 @default.
- W3177896031 hasAuthorship W3177896031A5045337979 @default.
- W3177896031 hasAuthorship W3177896031A5046389789 @default.
- W3177896031 hasAuthorship W3177896031A5059841476 @default.
- W3177896031 hasAuthorship W3177896031A5068249788 @default.
- W3177896031 hasAuthorship W3177896031A5080580164 @default.
- W3177896031 hasAuthorship W3177896031A5081099555 @default.
- W3177896031 hasAuthorship W3177896031A5086171339 @default.
- W3177896031 hasBestOaLocation W31778960311 @default.
- W3177896031 hasConcept C114851261 @default.
- W3177896031 hasConcept C119599485 @default.
- W3177896031 hasConcept C127413603 @default.
- W3177896031 hasConcept C142462285 @default.
- W3177896031 hasConcept C159047783 @default.
- W3177896031 hasConcept C187212893 @default.
- W3177896031 hasConcept C203014093 @default.
- W3177896031 hasConcept C2776283161 @default.
- W3177896031 hasConcept C2777275308 @default.
- W3177896031 hasConcept C2780252810 @default.
- W3177896031 hasConcept C2993143319 @default.
- W3177896031 hasConcept C3013748606 @default.
- W3177896031 hasConcept C54355233 @default.
- W3177896031 hasConcept C71924100 @default.
- W3177896031 hasConcept C761482 @default.
- W3177896031 hasConcept C78519656 @default.
- W3177896031 hasConcept C86803240 @default.
- W3177896031 hasConceptScore W3177896031C114851261 @default.
- W3177896031 hasConceptScore W3177896031C119599485 @default.
- W3177896031 hasConceptScore W3177896031C127413603 @default.
- W3177896031 hasConceptScore W3177896031C142462285 @default.
- W3177896031 hasConceptScore W3177896031C159047783 @default.
- W3177896031 hasConceptScore W3177896031C187212893 @default.
- W3177896031 hasConceptScore W3177896031C203014093 @default.
- W3177896031 hasConceptScore W3177896031C2776283161 @default.
- W3177896031 hasConceptScore W3177896031C2777275308 @default.
- W3177896031 hasConceptScore W3177896031C2780252810 @default.
- W3177896031 hasConceptScore W3177896031C2993143319 @default.
- W3177896031 hasConceptScore W3177896031C3013748606 @default.
- W3177896031 hasConceptScore W3177896031C54355233 @default.
- W3177896031 hasConceptScore W3177896031C71924100 @default.
- W3177896031 hasConceptScore W3177896031C761482 @default.
- W3177896031 hasConceptScore W3177896031C78519656 @default.
- W3177896031 hasConceptScore W3177896031C86803240 @default.
- W3177896031 hasLocation W31778960311 @default.
- W3177896031 hasLocation W31778960312 @default.
- W3177896031 hasLocation W31778960313 @default.
- W3177896031 hasLocation W31778960314 @default.
- W3177896031 hasOpenAccess W3177896031 @default.
- W3177896031 hasPrimaryLocation W31778960311 @default.
- W3177896031 hasRelatedWork W2021580285 @default.
- W3177896031 hasRelatedWork W2115919618 @default.
- W3177896031 hasRelatedWork W2267199453 @default.
- W3177896031 hasRelatedWork W2911784407 @default.
- W3177896031 hasRelatedWork W3186451085 @default.
- W3177896031 hasRelatedWork W3197334243 @default.
- W3177896031 hasRelatedWork W4229376368 @default.
- W3177896031 hasRelatedWork W4285329073 @default.
- W3177896031 hasRelatedWork W4298058916 @default.
- W3177896031 hasRelatedWork W2426612881 @default.
- W3177896031 isParatext "false" @default.
- W3177896031 isRetracted "false" @default.
- W3177896031 magId "3177896031" @default.
- W3177896031 workType "article" @default.