FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3177901864> ?p ?o ?g. }

• W3177901864 abstract "Abstract Anaerobic fungi and methanogenic archaea are two classes of microorganisms found in the rumen microbiome that metabolically interact during lignocellulose breakdown. Here, stable synthetic co-cultures of the anaerobic fungus Caecomyces churrovis and the methanogen Methanobacterium bryantii (not native to the rumen) were formed, demonstrating that microbes from different environments can be paired based on metabolic ties. Transcriptional and metabolic changes induced by methanogen co-culture were evaluated in C. churrovis across a variety of substrates to identify mechanisms that impact biomass breakdown and sugar uptake. A high-quality genome of C. churrovis was obtained and annotated, which is the first sequenced genome of a non-rhizoid forming anaerobic fungus. C. churrovis possess an abundance of CAZymes and carbohydrate binding modules and, in agreement with previous studies of early-diverging fungal lineages, N6-methyldeoxyadenine (6mA) was associated with transcriptionally active genes. Co-culture with the methanogen increased overall transcription of CAZymes, carbohydrate binding modules, and dockerin domains in co-cultures grown on both lignocellulose and cellulose and caused upregulation of genes coding associated enzymatic machinery including carbohydrate binding modules in family 18 and dockerin domains across multiple growth substrates relative to C. churrovis monoculture. Two other fungal strains grown on a reed canary grass substrate in co-culture with the same methanogen also exhibited high log2fold change values for upregulation of genes encoding carbohydrate binding modules in families 1 and 18. Transcriptional upregulation indicated that co-culture of the C. churrovis strain with a methanogen may enhance pyruvate formate lyase (PFL) function for growth on xylan and fructose and production of bottleneck enzymes in sugar utilization pathways, further supporting the hypothesis that co-culture with a methanogen may enhance certain fungal metabolic functions. Upregulation of CBM18 may play a role in fungal-methanogen physical associations and fungal cell wall development and remodeling." @default.
• W3177901864 created "2021-07-19" @default.
• W3177901864 creator A5007647654 @default.
• W3177901864 creator A5008136817 @default.
• W3177901864 creator A5009992437 @default.
• W3177901864 creator A5016090992 @default.
• W3177901864 creator A5022517633 @default.
• W3177901864 creator A5030829735 @default.
• W3177901864 creator A5033295580 @default.
• W3177901864 creator A5039488234 @default.
• W3177901864 creator A5046603848 @default.
• W3177901864 creator A5048779556 @default.
• W3177901864 creator A5051229050 @default.
• W3177901864 creator A5080692017 @default.
• W3177901864 creator A5084741576 @default.
• W3177901864 creator A5085719078 @default.
• W3177901864 date "2021-07-09" @default.
• W3177901864 modified "2023-09-26" @default.
• W3177901864 title "Co‑cultivation of the anaerobic fungus<i>Caecomyces churrovis</i>with<i>Methanobacterium bryantii</i>enhances transcription of carbohydrate binding modules" @default.
• W3177901864 cites W1226693753 @default.
• W3177901864 cites W1484309110 @default.
• W3177901864 cites W1522777641 @default.
• W3177901864 cites W1585864661 @default.
• W3177901864 cites W1823738905 @default.
• W3177901864 cites W1842339328 @default.
• W3177901864 cites W1901656938 @default.
• W3177901864 cites W1915404050 @default.
• W3177901864 cites W1964567273 @default.
• W3177901864 cites W1979640591 @default.
• W3177901864 cites W1987581698 @default.
• W3177901864 cites W1987916789 @default.
• W3177901864 cites W1988966516 @default.
• W3177901864 cites W1990499256 @default.
• W3177901864 cites W2000149056 @default.
• W3177901864 cites W2023353406 @default.
• W3177901864 cites W2025775139 @default.
• W3177901864 cites W2081265813 @default.
• W3177901864 cites W2097331301 @default.
• W3177901864 cites W2099399906 @default.
• W3177901864 cites W2101195004 @default.
• W3177901864 cites W2102278945 @default.
• W3177901864 cites W2108929776 @default.
• W3177901864 cites W2123106337 @default.
• W3177901864 cites W2130410032 @default.
• W3177901864 cites W2138207763 @default.
• W3177901864 cites W2145796553 @default.
• W3177901864 cites W2153628221 @default.
• W3177901864 cites W2156158823 @default.
• W3177901864 cites W2156649314 @default.
• W3177901864 cites W2158789637 @default.
• W3177901864 cites W2160300781 @default.
• W3177901864 cites W2165616649 @default.
• W3177901864 cites W2178780908 @default.
• W3177901864 cites W2179438025 @default.
• W3177901864 cites W2223717821 @default.
• W3177901864 cites W2275863076 @default.
• W3177901864 cites W2397212028 @default.
• W3177901864 cites W2410008680 @default.
• W3177901864 cites W2527008667 @default.
• W3177901864 cites W2561030438 @default.
• W3177901864 cites W2592074636 @default.
• W3177901864 cites W2612949335 @default.
• W3177901864 cites W2744488790 @default.
• W3177901864 cites W2759809410 @default.
• W3177901864 cites W2772885830 @default.
• W3177901864 cites W2778278506 @default.
• W3177901864 cites W2946515500 @default.
• W3177901864 cites W2947898698 @default.
• W3177901864 cites W2949448083 @default.
• W3177901864 cites W2954175826 @default.
• W3177901864 cites W2970696079 @default.
• W3177901864 cites W2983919513 @default.
• W3177901864 cites W3015473768 @default.
• W3177901864 cites W3095583226 @default.
• W3177901864 cites W3126279268 @default.
• W3177901864 cites W3128002411 @default.
• W3177901864 cites W3157658372 @default.
• W3177901864 cites W4250526798 @default.
• W3177901864 doi "https://doi.org/10.1101/2021.07.09.451685" @default.
• W3177901864 hasPublicationYear "2021" @default.
• W3177901864 type Work @default.
• W3177901864 sameAs 3177901864 @default.
• W3177901864 citedByCount "2" @default.
• W3177901864 countsByYear W31779018642021 @default.
• W3177901864 crossrefType "posted-content" @default.
• W3177901864 hasAuthorship W3177901864A5007647654 @default.
• W3177901864 hasAuthorship W3177901864A5008136817 @default.
• W3177901864 hasAuthorship W3177901864A5009992437 @default.
• W3177901864 hasAuthorship W3177901864A5016090992 @default.
• W3177901864 hasAuthorship W3177901864A5022517633 @default.
• W3177901864 hasAuthorship W3177901864A5030829735 @default.
• W3177901864 hasAuthorship W3177901864A5033295580 @default.
• W3177901864 hasAuthorship W3177901864A5039488234 @default.
• W3177901864 hasAuthorship W3177901864A5046603848 @default.
• W3177901864 hasAuthorship W3177901864A5048779556 @default.
• W3177901864 hasAuthorship W3177901864A5051229050 @default.
• W3177901864 hasAuthorship W3177901864A5080692017 @default.
• W3177901864 hasAuthorship W3177901864A5084741576 @default.
• W3177901864 hasAuthorship W3177901864A5085719078 @default.
• W3177901864 hasBestOaLocation W31779018641 @default.

• next