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• W3177908746 abstract "To report outcome and predictive factors in patients with N3 (> 6 cm) non-metastatic locally advanced head and neck squamous cell carcinoma (LAHNSCC) treated with a conservative approach or with initial surgery.104 patients were included: 69 treated with radiotherapy (RT) ± chemotherapy (CT) and 35 with nodal surgery with or without primary tumour resection, which was completed in 30 patients by adjuvant RT ± CT. Positron-emission tomography-computed tomography (PET-CT) guided surveillance after RT ± CT was standard.Two-year overall survival (OS) and locoregional control (LRC) were 39.4% and 37.5%, respectively. In univariate analysis, body mass index (BMI), performance status (PS), p16 status and haemoglobin value influenced OS and disease-free survival (DFS). In multivariate analysis, p16 positive status and BMI ≥ 25 remained independent prognostic factors for better OS (p = 0.023) and DFS (p = 0.002). Only under/normal weight remained an independent and adverse significant prognostic factor in multivariate analysis for regional control (RC). Patients treated with primary RT ± CT had slightly better 2-year OS (43.5% versus 33.3%, p = 0.31).Patients with N3 LAHNSCC have poor prognosis, but long term LRC is achievable, especially in overweight patients and those with a good PS.Il carcinoma squamocellulare della testa e collo con N3 (> 6 cm): risultati e fattori prognostici in 104 pazienti.Analizzare i risultati e fattori predittivi in pazienti con carcinoma a cellule squamose della testa e del collo localmente avanzato non metastatico con N3 (> 6 cm) (LAHNSCC N3) trattati con un approccio conservativo o con intervento chirurgico.Sono stati inclusi 104 pazienti: 69 trattati con radioterapia (RT) ± chemioterapia (CT) e 35 con chirurgia linfonodale con o senza resezione del tumore primario, di cui 30 pazienti con RT ± CT adiuvante. La sorveglianza dopo RT ± CT è stata eseguita mediante tomografia computerizzata a emissione di positroni (PET-TC).La sopravvivenza globale (OS) a 2 anni e il controllo locoregionale (LRC) erano rispettivamente del 39,4% e del 37,5%. Nell’analisi univariata, l’indice di massa corporea (BMI), il performance status (PS), lo stato di p16 e il valore dell’emoglobina hanno influenzato l’OS e la sopravvivenza libera da malattia (DFS). Nell’analisi multivariata, la positività di p16 e il BMI ≥ 25 sono rimasti fattori prognostici indipendenti per una migliore OS (p = 0,023) e DFS (p = 0,002). Lo stato di malnutrizione o normale status nutrizionale sono rimasti fattori prognostici significativi indipendenti e negativi nell’analisi multivariata per il controllo regionale (RC). I pazienti trattati con RT ± CT primaria avevano una OS a 2 anni leggermente migliore (43,5% contro 33,3%, p = 0,31).I pazienti con LAHNSCC N3 hanno una prognosi sfavorevole, ma è possibile ottenere un LRC a lungo termine, specialmente nei pazienti in sovrappeso e in quelli con un buon PS." @default.
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• W3177908746 date "2021-06-01" @default.
• W3177908746 modified "2023-09-27" @default.
• W3177908746 title "N3 (> 6 cm) squamous cell carcinoma of the head and neck: outcomes and predictive factors in 104 patients" @default.
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• W3177908746 doi "https://doi.org/10.14639/0392-100x-n1437" @default.
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