FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3177942712> ?p ?o ?g. }

• W3177942712 endingPage "2540" @default.
• W3177942712 startingPage "2525" @default.
• W3177942712 abstract "Hypoxanthine phosphoribosyltransferase (HPRT1), as a salvage pathway enzyme, plays a crucial role in modulating the cell cycle and has been reported to be overexpressed in multiple cancers. Nevertheless, the relationship between the HPRT1 gene and head and neck squamous cell carcinomas (HNSCCs) has not been investigated so far. In this study, we first evaluated the expression and clinical value of HPRT1 mRNA and protein in tumor and healthy control tissues. Then, we examined mutations of the HPRT1 gene and their association with survival outcomes of patients with HNSCC. We also performed functional analyses of HPRT1 coexpressed genes and examined the association between HPRT1 expression and drug sensitivity. Both HPRT1 mRNA and protein were significantly higher in HNSCC compared with normal tissues, and up-regulation of HPRT1 was also correlated with age, sex, pathological stage and histological grades of patients with HNSCC. Moreover, HPRT1 and its associated genes were observed to be enriched for several cancer-related pathways, including DNA replication and cell cycle. Finally, patients exhibiting overexpression of the HPRT1 gene may be resistant to abiraterone and sensitive to several drugs, including tozasertib and teniposide. This study demonstrated that the elevated expression of HPRT1 gene is correlated with the progression of HNSCC; thus, this gene may serve as a useful indicator for the early detection, risk stratification and targeted therapy of patients with HNSCC." @default.
• W3177942712 created "2021-07-19" @default.
• W3177942712 creator A5011009287 @default.
• W3177942712 creator A5024154308 @default.
• W3177942712 creator A5027221128 @default.
• W3177942712 creator A5027961642 @default.
• W3177942712 creator A5029619155 @default.
• W3177942712 creator A5052428133 @default.
• W3177942712 creator A5061490171 @default.
• W3177942712 creator A5077774864 @default.
• W3177942712 creator A5082465512 @default.
• W3177942712 date "2021-08-04" @default.
• W3177942712 modified "2023-10-02" @default.
• W3177942712 title "Overexpression of <i>HPRT1</i> is associated with poor prognosis in head and neck squamous cell carcinoma" @default.
• W3177942712 cites W1997534577 @default.
• W3177942712 cites W2012034410 @default.
• W3177942712 cites W2057818011 @default.
• W3177942712 cites W2085934079 @default.
• W3177942712 cites W2096906078 @default.
• W3177942712 cites W2106787323 @default.
• W3177942712 cites W2108607187 @default.
• W3177942712 cites W2114843025 @default.
• W3177942712 cites W2126496132 @default.
• W3177942712 cites W2149441684 @default.
• W3177942712 cites W2154362705 @default.
• W3177942712 cites W2178442747 @default.
• W3177942712 cites W2345356016 @default.
• W3177942712 cites W2522834523 @default.
• W3177942712 cites W2558715006 @default.
• W3177942712 cites W2602872538 @default.
• W3177942712 cites W2613629789 @default.
• W3177942712 cites W2749613778 @default.
• W3177942712 cites W2755331242 @default.
• W3177942712 cites W2771542157 @default.
• W3177942712 cites W2778855671 @default.
• W3177942712 cites W2779615732 @default.
• W3177942712 cites W2786825840 @default.
• W3177942712 cites W2808079838 @default.
• W3177942712 cites W2885117048 @default.
• W3177942712 cites W2885130104 @default.
• W3177942712 cites W2885303230 @default.
• W3177942712 cites W2889646458 @default.
• W3177942712 cites W2891269219 @default.
• W3177942712 cites W2897639752 @default.
• W3177942712 cites W2906554552 @default.
• W3177942712 cites W2918717228 @default.
• W3177942712 cites W2945731602 @default.
• W3177942712 cites W2947477242 @default.
• W3177942712 cites W2953041081 @default.
• W3177942712 cites W2957724045 @default.
• W3177942712 cites W2960854464 @default.
• W3177942712 cites W2963015311 @default.
• W3177942712 cites W2966364711 @default.
• W3177942712 cites W2967412867 @default.
• W3177942712 cites W2969975929 @default.
• W3177942712 cites W2970542149 @default.
• W3177942712 cites W2972545761 @default.
• W3177942712 cites W2978527819 @default.
• W3177942712 cites W2991587177 @default.
• W3177942712 cites W3007436353 @default.
• W3177942712 cites W3017955894 @default.
• W3177942712 cites W3033919438 @default.
• W3177942712 cites W3035440699 @default.
• W3177942712 cites W3036262785 @default.
• W3177942712 cites W3041259235 @default.
• W3177942712 cites W605097856 @default.
• W3177942712 cites W3007467865 @default.
• W3177942712 doi "https://doi.org/10.1002/2211-5463.13250" @default.
• W3177942712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8409317" @default.
• W3177942712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34231338" @default.
• W3177942712 hasPublicationYear "2021" @default.
• W3177942712 type Work @default.
• W3177942712 sameAs 3177942712 @default.
• W3177942712 citedByCount "11" @default.
• W3177942712 countsByYear W31779427122022 @default.
• W3177942712 countsByYear W31779427122023 @default.
• W3177942712 crossrefType "journal-article" @default.
• W3177942712 hasAuthorship W3177942712A5011009287 @default.
• W3177942712 hasAuthorship W3177942712A5024154308 @default.
• W3177942712 hasAuthorship W3177942712A5027221128 @default.
• W3177942712 hasAuthorship W3177942712A5027961642 @default.
• W3177942712 hasAuthorship W3177942712A5029619155 @default.
• W3177942712 hasAuthorship W3177942712A5052428133 @default.
• W3177942712 hasAuthorship W3177942712A5061490171 @default.
• W3177942712 hasAuthorship W3177942712A5077774864 @default.
• W3177942712 hasAuthorship W3177942712A5082465512 @default.
• W3177942712 hasBestOaLocation W31779427121 @default.
• W3177942712 hasConcept C104317684 @default.
• W3177942712 hasConcept C121608353 @default.
• W3177942712 hasConcept C1491633281 @default.
• W3177942712 hasConcept C150194340 @default.
• W3177942712 hasConcept C153911025 @default.
• W3177942712 hasConcept C2776530083 @default.
• W3177942712 hasConcept C2776833033 @default.
• W3177942712 hasConcept C29537977 @default.
• W3177942712 hasConcept C502942594 @default.
• W3177942712 hasConcept C54355233 @default.
• W3177942712 hasConcept C86803240 @default.

• next