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• W3178009076 abstract "In 1980, Roger Tsien published a paper, in this journal [Tsien, R. Y. (1980) Biochemistry, 19 (11), 2396], titled New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. These new buffers included 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid, or BAPTA, which is still widely used today. And so, the world was set alight with new ways in which to visualize Ca2+. The ability to watch fluctuations in intracellular Ca2+ revolutionized the life sciences, although the fluorescent indicators used today, particularly in neurobiology, no longer rely exclusively on BAPTA but on genetically encoded fluorescent Ca2+ indicators. In this Perspective, we reflect on the origins of Ca2+ imaging with a special focus on the contributions made by Roger Tsien, from the early concept of selective Ca2+ binding described in Biochemistry to optical Ca2+ indicators based on chemically synthesized fluorophores to genetically encoded fluorescent Ca2+ indicators." @default.
• W3178009076 created "2021-07-19" @default.
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• W3178009076 date "2021-07-12" @default.
• W3178009076 modified "2023-10-01" @default.
• W3178009076 title "Origins of Ca²⁺ Imaging with Fluorescent Indicators" @default.
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• W3178009076 doi "https://doi.org/10.1021/acs.biochem.1c00350" @default.
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