FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178039159> ?p ?o ?g. }

• W3178039159 endingPage "7423" @default.
• W3178039159 startingPage "7423" @default.
• W3178039159 abstract "Bombyx mori nucleopolyhedrovirus (BmNPV) is a pathogen that causes great economic losses in sericulture. Many genes play a role in viral infection of silkworms, but silkworm metabolism in response to BmNPV infection is unknown. We studied BmE cells infected with BmNPV. We performed liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)-based non-targeted metabolomics analysis of the cytosolic extract and identified 36, 76, 138, 101, 189, and 166 different molecules at 3, 6, 12, 24, 48, and 72 h post BmNPV infection (hpi) compared with 0 hpi. Compounds representing different areas of metabolism were increased in cells post BmNPV infection. These areas included purine metabolism, aminoacyl−tRNA biosynthesis, and ABC transporters. Glycerophosphocholine (GPC), 2-hydroxyadenine (2-OH-Ade), gamma-glutamylcysteine (γ-Glu-Cys), hydroxytolbutamide, and 5-pyridoxolactone glycerophosphocholine were continuously upregulated in BmE cells post BmNPV infection by heat map analysis. Only 5-pyridoxolactone was found to strongly inhibit the proliferation of BmNPV when it was used to treat BmE cells. Fewer infected cells were detected and the level of BmNPV DNA decreased with increasing 5-pyridoxolactone in a dose-dependent manner. The expression of BmNPV genes ie1, helicase, GP64, and VP39 in BmE cells treated with 5-pyridoxolactone were strongly inhibited in the BmNPV infection stage. This suggested that 5-pyridoxolactone may suppress the entry of BmNPV. The data in this study characterize the metabolism changes in BmNPV-infected cells. Further analysis of 5-pyridoxolactone, which is a robust antiviral molecule, may increase our understanding of antiviral immunity." @default.
• W3178039159 created "2021-07-19" @default.
• W3178039159 creator A5001859212 @default.
• W3178039159 creator A5037578357 @default.
• W3178039159 creator A5041326706 @default.
• W3178039159 creator A5055720455 @default.
• W3178039159 creator A5057194915 @default.
• W3178039159 creator A5079410647 @default.
• W3178039159 creator A5086529957 @default.
• W3178039159 date "2021-07-10" @default.
• W3178039159 modified "2023-10-17" @default.
• W3178039159 title "The Antiviral Molecule 5-Pyridoxolactone Identified Post BmNPV Infection of the Silkworm, Bombyx mori" @default.
• W3178039159 cites W1498280680 @default.
• W3178039159 cites W1568279709 @default.
• W3178039159 cites W1575737685 @default.
• W3178039159 cites W1590944458 @default.
• W3178039159 cites W1976327004 @default.
• W3178039159 cites W1983546624 @default.
• W3178039159 cites W1988165548 @default.
• W3178039159 cites W1993311973 @default.
• W3178039159 cites W2002139518 @default.
• W3178039159 cites W2037009738 @default.
• W3178039159 cites W2042927392 @default.
• W3178039159 cites W2063929091 @default.
• W3178039159 cites W2075266851 @default.
• W3178039159 cites W2075611506 @default.
• W3178039159 cites W2078733629 @default.
• W3178039159 cites W2079462554 @default.
• W3178039159 cites W2083468378 @default.
• W3178039159 cites W2089698943 @default.
• W3178039159 cites W2093146885 @default.
• W3178039159 cites W2093910431 @default.
• W3178039159 cites W2115309092 @default.
• W3178039159 cites W2157594098 @default.
• W3178039159 cites W2157923275 @default.
• W3178039159 cites W2167915266 @default.
• W3178039159 cites W2385100949 @default.
• W3178039159 cites W2523719104 @default.
• W3178039159 cites W2594933406 @default.
• W3178039159 cites W2625766497 @default.
• W3178039159 cites W2794527909 @default.
• W3178039159 cites W2799637227 @default.
• W3178039159 cites W2805888792 @default.
• W3178039159 cites W2883453009 @default.
• W3178039159 cites W2893534580 @default.
• W3178039159 cites W2904567276 @default.
• W3178039159 cites W2906024285 @default.
• W3178039159 cites W2923141379 @default.
• W3178039159 cites W2923433444 @default.
• W3178039159 cites W2934026912 @default.
• W3178039159 cites W2938000227 @default.
• W3178039159 cites W2949840475 @default.
• W3178039159 cites W2971979108 @default.
• W3178039159 cites W3027573401 @default.
• W3178039159 cites W3047682035 @default.
• W3178039159 cites W3110116682 @default.
• W3178039159 cites W3122680312 @default.
• W3178039159 cites W3128306458 @default.
• W3178039159 doi "https://doi.org/10.3390/ijms22147423" @default.
• W3178039159 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8307608" @default.
• W3178039159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34299043" @default.
• W3178039159 hasPublicationYear "2021" @default.
• W3178039159 type Work @default.
• W3178039159 sameAs 3178039159 @default.
• W3178039159 citedByCount "3" @default.
• W3178039159 countsByYear W31780391592023 @default.
• W3178039159 crossrefType "journal-article" @default.
• W3178039159 hasAuthorship W3178039159A5001859212 @default.
• W3178039159 hasAuthorship W3178039159A5037578357 @default.
• W3178039159 hasAuthorship W3178039159A5041326706 @default.
• W3178039159 hasAuthorship W3178039159A5055720455 @default.
• W3178039159 hasAuthorship W3178039159A5057194915 @default.
• W3178039159 hasAuthorship W3178039159A5079410647 @default.
• W3178039159 hasAuthorship W3178039159A5086529957 @default.
• W3178039159 hasBestOaLocation W31780391591 @default.
• W3178039159 hasConcept C104317684 @default.
• W3178039159 hasConcept C153911025 @default.
• W3178039159 hasConcept C159047783 @default.
• W3178039159 hasConcept C21565614 @default.
• W3178039159 hasConcept C2522874641 @default.
• W3178039159 hasConcept C2776460866 @default.
• W3178039159 hasConcept C2778487026 @default.
• W3178039159 hasConcept C55493867 @default.
• W3178039159 hasConcept C60644358 @default.
• W3178039159 hasConcept C62231903 @default.
• W3178039159 hasConcept C86803240 @default.
• W3178039159 hasConcept C89423630 @default.
• W3178039159 hasConceptScore W3178039159C104317684 @default.
• W3178039159 hasConceptScore W3178039159C153911025 @default.
• W3178039159 hasConceptScore W3178039159C159047783 @default.
• W3178039159 hasConceptScore W3178039159C21565614 @default.
• W3178039159 hasConceptScore W3178039159C2522874641 @default.
• W3178039159 hasConceptScore W3178039159C2776460866 @default.
• W3178039159 hasConceptScore W3178039159C2778487026 @default.
• W3178039159 hasConceptScore W3178039159C55493867 @default.
• W3178039159 hasConceptScore W3178039159C60644358 @default.
• W3178039159 hasConceptScore W3178039159C62231903 @default.
• W3178039159 hasConceptScore W3178039159C86803240 @default.

• next