FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178097844> ?p ?o ?g. }

• W3178097844 endingPage "7556" @default.
• W3178097844 startingPage "7556" @default.
• W3178097844 abstract "The benefits of a ketogenic diet in childhood epilepsy steered up hope for neuroprotective effects of hyperketonemia in Parkinson’s disease (PD). There are multiple theoretical reasons but very little actual experimental proof or clinical trials. We examined the long-term effects of the ketogenic diet in an animal model of early PD. A progressive, selective dopaminergic medium size lesion was induced by 6-OHDA injection into the medial forebrain bundle. Animals were kept on the stringent ketogenic diet (1% carbohydrates, 8% protein, 70% fat) for 3 weeks prior and 4 weeks after the brain operation. Locomotor activity, neuron count, dopaminergic terminal density, dopamine level, and turnover were analyzed at three time-points post-lesion, up to 4 weeks after the operation. Energy metabolism parameters (glycogen, mitochondrial complex I and IV, lactate, beta-hydroxybutyrate, glucose) were analyzed in the brain and liver or plasma. Protein expression of enzymes essential for gluconeogenesis (PEPCK, G6PC) and glucose utilization (GCK) was analyzed in the liver. Despite long-term hyperketonemia pre- and post-lesion, the ketogenic diet did not protect against 6-OHDA-induced dopaminergic neuron lesions. The ketogenic diet only tended to improve locomotor activity and normalize DA turnover in the striatum. Rats fed 7 weeks in total with a restrictive ketogenic diet maintained normoglycemia, and neither gluconeogenesis nor glycogenolysis in the liver was responsible for this effect. Therefore, potentially, the ketogenic diet could be therapeutically helpful to support the late compensatory mechanisms active via glial cells but does not necessarily act against the oxidative stress-induced parkinsonian neurodegeneration itself. A word of caution is required as the stringent ketogenic diet itself also carries the risk of unwanted side effects, so it is important to study the long-term effects of such treatments. More detailed metabolic long-term studies using unified diet parameters are required, and human vs. animal differences should be taken under consideration." @default.
• W3178097844 created "2021-07-19" @default.
• W3178097844 creator A5043279454 @default.
• W3178097844 creator A5054138845 @default.
• W3178097844 creator A5065698902 @default.
• W3178097844 creator A5073451833 @default.
• W3178097844 date "2021-07-14" @default.
• W3178097844 modified "2023-09-26" @default.
• W3178097844 title "Increased Beta-Hydroxybutyrate Level Is Not Sufficient for the Neuroprotective Effect of Long-Term Ketogenic Diet in an Animal Model of Early Parkinson’s Disease. Exploration of Brain and Liver Energy Metabolism Markers" @default.
• W3178097844 cites W1830693004 @default.
• W3178097844 cites W1919215073 @default.
• W3178097844 cites W1938553409 @default.
• W3178097844 cites W1963833954 @default.
• W3178097844 cites W1964037209 @default.
• W3178097844 cites W1964452506 @default.
• W3178097844 cites W1968981446 @default.
• W3178097844 cites W1972141465 @default.
• W3178097844 cites W1976609253 @default.
• W3178097844 cites W1980142052 @default.
• W3178097844 cites W1982170666 @default.
• W3178097844 cites W1987656015 @default.
• W3178097844 cites W1988362340 @default.
• W3178097844 cites W1990210604 @default.
• W3178097844 cites W1992365876 @default.
• W3178097844 cites W1993988048 @default.
• W3178097844 cites W1995657434 @default.
• W3178097844 cites W1998741437 @default.
• W3178097844 cites W2001861024 @default.
• W3178097844 cites W2010960367 @default.
• W3178097844 cites W2014755727 @default.
• W3178097844 cites W2015828489 @default.
• W3178097844 cites W2018444039 @default.
• W3178097844 cites W2018460396 @default.
• W3178097844 cites W2025410950 @default.
• W3178097844 cites W2034763077 @default.
• W3178097844 cites W2036623633 @default.
• W3178097844 cites W2040661435 @default.
• W3178097844 cites W2055148149 @default.
• W3178097844 cites W2062447656 @default.
• W3178097844 cites W2062838885 @default.
• W3178097844 cites W2065278560 @default.
• W3178097844 cites W2080995987 @default.
• W3178097844 cites W2081262717 @default.
• W3178097844 cites W2082355828 @default.
• W3178097844 cites W2099402363 @default.
• W3178097844 cites W2101042964 @default.
• W3178097844 cites W2104382375 @default.
• W3178097844 cites W2112648950 @default.
• W3178097844 cites W2157369540 @default.
• W3178097844 cites W2163495305 @default.
• W3178097844 cites W2164061949 @default.
• W3178097844 cites W2167309544 @default.
• W3178097844 cites W2172136900 @default.
• W3178097844 cites W2184015870 @default.
• W3178097844 cites W2229282577 @default.
• W3178097844 cites W2258075909 @default.
• W3178097844 cites W2273168336 @default.
• W3178097844 cites W2296585153 @default.
• W3178097844 cites W247158544 @default.
• W3178097844 cites W2543080048 @default.
• W3178097844 cites W2552776938 @default.
• W3178097844 cites W2561414178 @default.
• W3178097844 cites W2596693353 @default.
• W3178097844 cites W2602703797 @default.
• W3178097844 cites W2610457025 @default.
• W3178097844 cites W2614352140 @default.
• W3178097844 cites W2615179214 @default.
• W3178097844 cites W2620988363 @default.
• W3178097844 cites W2734983874 @default.
• W3178097844 cites W2784357120 @default.
• W3178097844 cites W2790678901 @default.
• W3178097844 cites W2801963064 @default.
• W3178097844 cites W2802113204 @default.
• W3178097844 cites W2887866827 @default.
• W3178097844 cites W2890259736 @default.
• W3178097844 cites W2897460570 @default.
• W3178097844 cites W2900333403 @default.
• W3178097844 cites W2905784334 @default.
• W3178097844 cites W2910859275 @default.
• W3178097844 cites W2944986477 @default.
• W3178097844 cites W2952477531 @default.
• W3178097844 cites W2973170171 @default.
• W3178097844 cites W2988639307 @default.
• W3178097844 cites W2998904632 @default.
• W3178097844 cites W3004000132 @default.
• W3178097844 cites W3022000657 @default.
• W3178097844 cites W3035843643 @default.
• W3178097844 cites W3038745575 @default.
• W3178097844 cites W3040864622 @default.
• W3178097844 cites W3047644332 @default.
• W3178097844 cites W3092773215 @default.
• W3178097844 cites W3103776403 @default.
• W3178097844 cites W4242174061 @default.
• W3178097844 doi "https://doi.org/10.3390/ijms22147556" @default.
• W3178097844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8307513" @default.
• W3178097844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34299176" @default.
• W3178097844 hasPublicationYear "2021" @default.
• W3178097844 type Work @default.

• next