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- W3178110135 endingPage "R54" @default.
- W3178110135 startingPage "R35" @default.
- W3178110135 abstract "Orphan nuclear receptors (ONRs) are a subset of the nuclear receptor family that lacks known endogenous ligands. Among 48 nuclear receptors identified in humans, 25 are classified as ONRs. They function as transcription factors and control the expression of a wide range of genes to regulate metabolism, fertility, immunity, angiogenesis, and many other functions. Angiogenic factors are essential during ovarian follicle development, including follicle growth and ovulation. The correct development of blood vessels contributes to preantral and antral follicular development, selection of the dominant follicle or follicles, follicular atresia, and ovulation. Although progress has been made in understanding the molecular mechanisms that regulate follicular angiogenesis, the role of ONRs as regulators is not clear. Based on their functions in other tissues, the ONRs NR1D1 (REV-ERBβ), NR2C2 (TR4), NR2F2 (COUP-TF-II) and NR3B1, 2, and 3 (ERRα, ERRβ and ERRγ) may modulate angiogenesis during antral follicle development. We hypothesize that this is achieved by effects on the expression and function of VEGFA, ANGPT1, THBS1, and soluble VEGFR1. Further, angiogenesis during ovulation is expected to be influenced by ONRs. NR5A2 (LRH-1), which is required for ovulation, regulates angiogenic genes in the ovary, including VEGFA and the upstream regulator of angiogenesis, PGE2. These angiogenic molecules may also be regulated by NR5A1 (SF-1). Evidence from outside the reproductive tract suggests that NR2F2 and NR4A1(NUR77) promote VEGFC and PGF, respectively, and NR4As (NUR77, NOR1) seem to be necessary for the angiogenic effects of VEGFA and PGE2. Together, the data suggest that ONRs are important regulators of follicular angiogenesis." @default.
- W3178110135 created "2021-07-19" @default.
- W3178110135 creator A5004975899 @default.
- W3178110135 creator A5019136135 @default.
- W3178110135 creator A5080047281 @default.
- W3178110135 date "2021-09-01" @default.
- W3178110135 modified "2023-10-17" @default.
- W3178110135 title "Orphan nuclear receptors in angiogenesis and follicular development" @default.
- W3178110135 cites W1505090413 @default.
- W3178110135 cites W1505805985 @default.
- W3178110135 cites W1520624885 @default.
- W3178110135 cites W1796122241 @default.
- W3178110135 cites W1824405363 @default.
- W3178110135 cites W1919133853 @default.
- W3178110135 cites W1956526745 @default.
- W3178110135 cites W1963692554 @default.
- W3178110135 cites W1964461833 @default.
- W3178110135 cites W1971875928 @default.
- W3178110135 cites W1972872761 @default.
- W3178110135 cites W1973606269 @default.
- W3178110135 cites W1975672275 @default.
- W3178110135 cites W1976221241 @default.
- W3178110135 cites W1980884233 @default.
- W3178110135 cites W1981862471 @default.
- W3178110135 cites W1982846641 @default.
- W3178110135 cites W1983669063 @default.
- W3178110135 cites W1984475639 @default.
- W3178110135 cites W1992049575 @default.
- W3178110135 cites W1995310127 @default.
- W3178110135 cites W2002757138 @default.
- W3178110135 cites W2002959545 @default.
- W3178110135 cites W2003702751 @default.
- W3178110135 cites W2009224756 @default.
- W3178110135 cites W2014577656 @default.
- W3178110135 cites W2015536558 @default.
- W3178110135 cites W2016798180 @default.
- W3178110135 cites W2021201525 @default.
- W3178110135 cites W2022333470 @default.
- W3178110135 cites W2024112779 @default.
- W3178110135 cites W2027494570 @default.
- W3178110135 cites W2028327837 @default.
- W3178110135 cites W2029163336 @default.
- W3178110135 cites W2037598307 @default.
- W3178110135 cites W2048459905 @default.
- W3178110135 cites W2050567531 @default.
- W3178110135 cites W2058641388 @default.
- W3178110135 cites W2059322719 @default.
- W3178110135 cites W2062948400 @default.
- W3178110135 cites W2064937641 @default.
- W3178110135 cites W2067785496 @default.
- W3178110135 cites W2072362233 @default.
- W3178110135 cites W2075018019 @default.
- W3178110135 cites W2076524169 @default.
- W3178110135 cites W2076647080 @default.
- W3178110135 cites W2078282845 @default.
- W3178110135 cites W2079350549 @default.
- W3178110135 cites W2080593512 @default.
- W3178110135 cites W2081371197 @default.
- W3178110135 cites W2086130053 @default.
- W3178110135 cites W2095029045 @default.
- W3178110135 cites W2096072209 @default.
- W3178110135 cites W2098793470 @default.
- W3178110135 cites W2099252399 @default.
- W3178110135 cites W2100821129 @default.
- W3178110135 cites W2101213596 @default.
- W3178110135 cites W2102002812 @default.
- W3178110135 cites W2102074716 @default.
- W3178110135 cites W2102075349 @default.
- W3178110135 cites W2102488819 @default.
- W3178110135 cites W2104290916 @default.
- W3178110135 cites W2105004463 @default.
- W3178110135 cites W2109159616 @default.
- W3178110135 cites W2110453175 @default.
- W3178110135 cites W2112262827 @default.
- W3178110135 cites W2113462070 @default.
- W3178110135 cites W2114545853 @default.
- W3178110135 cites W2115188607 @default.
- W3178110135 cites W2116618443 @default.
- W3178110135 cites W2120847343 @default.
- W3178110135 cites W2122463654 @default.
- W3178110135 cites W2126994474 @default.
- W3178110135 cites W2130356372 @default.
- W3178110135 cites W2131961719 @default.
- W3178110135 cites W2133867463 @default.
- W3178110135 cites W2136307362 @default.
- W3178110135 cites W2137512583 @default.
- W3178110135 cites W2137918853 @default.
- W3178110135 cites W2141604741 @default.
- W3178110135 cites W2147427742 @default.
- W3178110135 cites W2150899372 @default.
- W3178110135 cites W2153078549 @default.
- W3178110135 cites W2153346388 @default.
- W3178110135 cites W2153969356 @default.
- W3178110135 cites W2154982209 @default.
- W3178110135 cites W2156281856 @default.
- W3178110135 cites W2157313762 @default.
- W3178110135 cites W2160313445 @default.
- W3178110135 cites W2164215458 @default.