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• W3178146247 abstract "Fusarium circinatum is an important pathogen of pine trees. However, little is known regarding the molecular processes underlying its pathogenesis. We explored the potential role of the phytotoxin fusaric acid (FA) in the pathogenicity of the fungus. FA is produced by products of the FUB biosynthesis gene cluster, containing FUB1-12. Of these, FUB1 encodes the core polyketide synthase, which we disrupted. We used the resulting mutant strain to investigate whether FUB1 and FA production play a role in the virulence of F. circinatum on pine. Our results showed that FA production was abolished both in vitro and in planta. However, bikaverin production was increased in the knockout mutant. FUB1 disruption also corresponded with downregulation of a F. circinatum homologue of LaeA, a master transcriptional regulator of secondary metabolism. Lesion lengths produced by the FUB1 knockout mutant on inoculated Pinus patula seedlings were significantly smaller than those produced by the wild type strain. Collectively, these results show that FUB1 plays a role in FA production in F. circinatum, and that this gene contributes to the aggressiveness of F. circinatum on P. patula. This study will contribute to the limited knowledge we have about the molecular basis of pathogenicity in this fungus." @default.
• W3178146247 created "2021-07-19" @default.
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• W3178146247 date "2021-12-01" @default.
• W3178146247 modified "2023-10-13" @default.
• W3178146247 title "Deciphering the effect of FUB1 disruption on fusaric acid production and pathogenicity in Fusarium circinatum" @default.
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• W3178146247 doi "https://doi.org/10.1016/j.funbio.2021.07.002" @default.
• W3178146247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34776231" @default.
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