FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178147068> ?p ?o ?g. }

• W3178147068 endingPage "3371" @default.
• W3178147068 startingPage "3371" @default.
• W3178147068 abstract "Transcriptome data provide a valuable resource for the study of cancer molecular mechanisms, but technical biases, sample heterogeneity, and small sample sizes result in poorly reproducible lists of regulated genes. Additionally, the presence of multiple cellular components contributing to cancer development complicates the interpretation of bulk transcriptomic profiles. To address these issues, we collected 48 microarray datasets derived from laser capture microdissected stroma or epithelium in breast tumors and performed a meta-analysis identifying robust lists of differentially expressed genes. This was used to create a database with carefully harmonized metadata that we make freely available to the research community. As predicted, combining the results of multiple datasets improved statistical power. Moreover, the separate analysis of stroma and epithelium allowed the identification of genes with different contributions in each compartment, which would not be detected by bulk analysis due to their distinct regulation in the two compartments. Our method can be profitably used to help in the discovery of biomarkers and the identification of functionally relevant genes in both the stroma and the epithelium. This database was made to be readily accessible through a user-friendly web interface." @default.
• W3178147068 created "2021-07-19" @default.
• W3178147068 creator A5012414728 @default.
• W3178147068 creator A5019791912 @default.
• W3178147068 creator A5063120064 @default.
• W3178147068 creator A5088961434 @default.
• W3178147068 date "2021-07-05" @default.
• W3178147068 modified "2023-10-15" @default.
• W3178147068 title "Meta-Analysis of Microdissected Breast Tumors Reveals Genes Regulated in the Stroma but Hidden in Bulk Analysis" @default.
• W3178147068 cites W1567333450 @default.
• W3178147068 cites W1590628678 @default.
• W3178147068 cites W1629202041 @default.
• W3178147068 cites W1690786713 @default.
• W3178147068 cites W1699726044 @default.
• W3178147068 cites W1833991130 @default.
• W3178147068 cites W1930726764 @default.
• W3178147068 cites W1968428572 @default.
• W3178147068 cites W1968765579 @default.
• W3178147068 cites W1969512609 @default.
• W3178147068 cites W1980750965 @default.
• W3178147068 cites W1981849943 @default.
• W3178147068 cites W1989223606 @default.
• W3178147068 cites W1989688078 @default.
• W3178147068 cites W1990005647 @default.
• W3178147068 cites W2004442803 @default.
• W3178147068 cites W2007227595 @default.
• W3178147068 cites W2015754479 @default.
• W3178147068 cites W2018486347 @default.
• W3178147068 cites W2020556380 @default.
• W3178147068 cites W2028395883 @default.
• W3178147068 cites W2032646886 @default.
• W3178147068 cites W2033998652 @default.
• W3178147068 cites W2035252444 @default.
• W3178147068 cites W2035618305 @default.
• W3178147068 cites W2037966798 @default.
• W3178147068 cites W2042462356 @default.
• W3178147068 cites W2045949302 @default.
• W3178147068 cites W2048383496 @default.
• W3178147068 cites W2057430646 @default.
• W3178147068 cites W2058225402 @default.
• W3178147068 cites W2061070237 @default.
• W3178147068 cites W2062265555 @default.
• W3178147068 cites W2073755222 @default.
• W3178147068 cites W2079709165 @default.
• W3178147068 cites W2079923725 @default.
• W3178147068 cites W2086695276 @default.
• W3178147068 cites W2091947792 @default.
• W3178147068 cites W2096283457 @default.
• W3178147068 cites W2100239923 @default.
• W3178147068 cites W2101039596 @default.
• W3178147068 cites W2102461795 @default.
• W3178147068 cites W2117692326 @default.
• W3178147068 cites W2118258530 @default.
• W3178147068 cites W2120004030 @default.
• W3178147068 cites W2122673439 @default.
• W3178147068 cites W2124201592 @default.
• W3178147068 cites W2129778189 @default.
• W3178147068 cites W2130430382 @default.
• W3178147068 cites W2131717611 @default.
• W3178147068 cites W2132165198 @default.
• W3178147068 cites W2133336743 @default.
• W3178147068 cites W2134037189 @default.
• W3178147068 cites W2134539328 @default.
• W3178147068 cites W2140817808 @default.
• W3178147068 cites W2141235890 @default.
• W3178147068 cites W2141815918 @default.
• W3178147068 cites W2146512944 @default.
• W3178147068 cites W2149398604 @default.
• W3178147068 cites W2152155643 @default.
• W3178147068 cites W2152667098 @default.
• W3178147068 cites W2154005451 @default.
• W3178147068 cites W2154981570 @default.
• W3178147068 cites W2156555688 @default.
• W3178147068 cites W2158795833 @default.
• W3178147068 cites W2159707944 @default.
• W3178147068 cites W2160237679 @default.
• W3178147068 cites W2161368206 @default.
• W3178147068 cites W2162376722 @default.
• W3178147068 cites W2164171082 @default.
• W3178147068 cites W2169360530 @default.
• W3178147068 cites W2172215633 @default.
• W3178147068 cites W2185207072 @default.
• W3178147068 cites W2204165780 @default.
• W3178147068 cites W2214074259 @default.
• W3178147068 cites W2230320310 @default.
• W3178147068 cites W2337770131 @default.
• W3178147068 cites W2344060455 @default.
• W3178147068 cites W2400526229 @default.
• W3178147068 cites W2430731787 @default.
• W3178147068 cites W2471536144 @default.
• W3178147068 cites W2529965383 @default.
• W3178147068 cites W2553056330 @default.
• W3178147068 cites W2580168332 @default.
• W3178147068 cites W2588167481 @default.
• W3178147068 cites W2610509384 @default.
• W3178147068 cites W2619222745 @default.
• W3178147068 cites W2662801289 @default.
• W3178147068 cites W2732875761 @default.

• next