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- W3178147211 abstract "Objective To investigate the photodynamic effect of IR-820 and perfluoropentane (PFP) loaded phasetransition multifunctional molecular imaging probe (IR-820/PFP@PLGA NPs) on ultrasound/photoacoustic dual-mode imaging and fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis (RA) in vitro. Methods The IR-820/PFP@PLGA nanoparticles were prepared by double emulsification method. The basic characteristics, thermal phase transition and photothermal effect of IR-820/PFP@PLGA nanoparticles were determined, the ultrasound/photoacoustic dual-mode imaging ability in vitro of the IR-820/PFP@PLGA nanoparticles were observed, and the generation of reactive oxygen species in vitro were evaluated. The photodynamic therapy effect of the nanoparticles on fibroblast-like synoviocytes was observed by CCK-8 method and flow cytometry. Results The prepared IR-820/PFP@PLGA nanoparticles were dark green, with a particle size of (261.8±3.2) nm and a potential of (–27.4±0.7) mV. The size of the IR-820/PFP@PLGA nanoparticles were uniform and the morphology were regular. The size of nanoparticles and the temperature of nanoparticle solution increased obviously by laser irradiation, it was positively correlated with the concentration of nanoparticles, and enhanced ultrasound imaging was observed. The photoacoustic imaging effect of nanoparticle was linearly correlated with the concentration of IR-820/PFP@PLGA nanoparticles; The singlet oxygen sensor green (SOSG) assay revealed that the nanoparticles produced a large amount of reactive oxygen species after laser irradiation with timedependent manner; it was found by in vitro cell experiments that the nanoparticles had good biological safety, while the cytotoxicity increased along with the advanced nanoparticle concentration after laser irradiation, and also the apoptosis increased significantly. Conclusion IR-820/PFP@PLGA nanoparticles have a good dual-mode imaging and photodynamic effect on FLSs, which can provide a new idea for the integration of diagnosis and treatment for RA.DOI: 10.11855/j.issn.0577-7402.2021.05.01" @default.
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- W3178147211 date "2021-05-01" @default.
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- W3178147211 title "IR-820 loaded phase transition nanoparticles for dual-modal imaging and photodynamic effect on fibroblast-like synoviocytes of rheumatoid arthritis in vitro" @default.
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