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• W3178156762 startingPage "248" @default.
• W3178156762 abstract "Treatment of full-thickness skin defects still presents a significant challenge in clinical practice. Three-dimensional (3D) bioprinting technique offers a promising approach for fabricating skin substitutes. However, it is necessary to identify bioinks that have both sufficient mechanical properties and desirable biocompatibilities. In this study, we successfully fabricated acellular dermal matrix (ADM) and gelatin methacrylamide (GelMA) bioinks. The results demonstrated that ADM preserved the main extracellular matrix (ECM) components of the skin and GelMA had tunable mechanical properties. Both bioinks with shear-thinning properties were suitable for 3D bioprinting and GelMA bioink exhibited high printability. Additionally, the results revealed that 20% GelMA with sufficient mechanical properties was suitable to engineer epidermis, 1.5% ADM and 10% GelMA displayed relatively good cytocompatibilities. Here, we proposed a new 3D structure to simulate natural full-thickness skin, which included 20% GelMA with HaCaTs as an epidermal layer, 1.5% ADM with fibroblasts as the dermis, and 10% GelMA mesh with human umbilical vein endothelial cells (HUVECs) as the vascular network and framework. We demonstrated that this 3D bioprinting functional skin model (FSM) could not only promote cell viability and proliferation, but also support epidermis reconstruction in vitro. When transplanted in vivo, the FSM could maintain cell viability for at least 1 week. Furthermore, the FSM promoted wound healing and re-epithelization, stimulated dermal ECM secretion and angiogenesis, and improved wound healing quality. The FSM may provide viable functional skin substitutes for future clinical applications. We propose a new 3D structure to simulate natural full-thickness skin, which included 20% GelMA with HaCaTs as an epidermal layer, 1.5% ADM with fibroblasts as the dermis, and 10% GelMA mesh with HUVECs as the vascular network. It could not only maintain a moist microenvironment and barrier function, but also recreate the natural skin microenvironment to promote cell viability and proliferation. This may provide viable functional skin substitutes for future clinical applications." @default.
• W3178156762 created "2021-07-19" @default.
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• W3178156762 date "2021-09-01" @default.
• W3178156762 modified "2023-10-18" @default.
• W3178156762 title "Three-dimensional bioprinting of a full-thickness functional skin model using acellular dermal matrix and gelatin methacrylamide bioink" @default.
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• W3178156762 cites W1878402616 @default.
• W3178156762 cites W1904003583 @default.
• W3178156762 cites W1926182254 @default.
• W3178156762 cites W1959582520 @default.
• W3178156762 cites W1978036354 @default.
• W3178156762 cites W1983187572 @default.
• W3178156762 cites W1984201264 @default.
• W3178156762 cites W1996795547 @default.
• W3178156762 cites W2007055685 @default.
• W3178156762 cites W2014482422 @default.
• W3178156762 cites W2014562403 @default.
• W3178156762 cites W2016058943 @default.
• W3178156762 cites W2028283357 @default.
• W3178156762 cites W2039107709 @default.
• W3178156762 cites W2044309344 @default.
• W3178156762 cites W2046512170 @default.
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• W3178156762 cites W2103018363 @default.
• W3178156762 cites W2117222587 @default.
• W3178156762 cites W2130171570 @default.
• W3178156762 cites W2133683725 @default.
• W3178156762 cites W2141738357 @default.
• W3178156762 cites W2143912820 @default.
• W3178156762 cites W2144623505 @default.
• W3178156762 cites W2161824899 @default.
• W3178156762 cites W2170106855 @default.
• W3178156762 cites W2170534668 @default.
• W3178156762 cites W2171314179 @default.
• W3178156762 cites W2187525303 @default.
• W3178156762 cites W2203385592 @default.
• W3178156762 cites W2295373939 @default.
• W3178156762 cites W2327492614 @default.
• W3178156762 cites W2345714144 @default.
• W3178156762 cites W2394524191 @default.
• W3178156762 cites W2556373707 @default.
• W3178156762 cites W2559349367 @default.
• W3178156762 cites W2560213782 @default.
• W3178156762 cites W2579302807 @default.
• W3178156762 cites W2589235131 @default.
• W3178156762 cites W2610636146 @default.
• W3178156762 cites W2752164271 @default.
• W3178156762 cites W2762265835 @default.
• W3178156762 cites W2790281145 @default.
• W3178156762 cites W2791975433 @default.
• W3178156762 cites W2884607034 @default.
• W3178156762 cites W2892397780 @default.
• W3178156762 cites W2898563552 @default.
• W3178156762 cites W2904695287 @default.
• W3178156762 cites W2907384233 @default.
• W3178156762 cites W2915507219 @default.
• W3178156762 cites W2915703585 @default.
• W3178156762 cites W2917207645 @default.
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• W3178156762 doi "https://doi.org/10.1016/j.actbio.2021.07.012" @default.
• W3178156762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34265473" @default.
• W3178156762 hasPublicationYear "2021" @default.
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