FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178159464> ?p ?o ?g. }

• W3178159464 abstract "Fibrillation of peptides and proteins is implicated in various neurodegenerative diseases and is a global concern. Aging leads to the formation of abnormal isoaspartate (isoAsp) residues from isomerization of normal aspartates in proteins, triggering fibril formation that leads to neurodegenerative diseases. Protein L-isoaspartyl methyltransferase (PIMT) is a repair enzyme which recognizes and converts altered isoAsp residues back to normal aspartate. Here we report the effect of gold nanoparticles (AuNPs) of different sizes on the structure and function of PIMT. Spherical AuNPs, viz. AuNS5, AuNS50 and AuNS100 (the number indicating the diameter in nm) stabilize PIMT, with AuNS100 exhibiting the best efficacy, as evident from various biophysical experiments. Isothermal titration calorimetry (ITC) revealed endothermic, but entropy driven mode of binding of PIMT with all the three AuNSs. Methyltransferase activity assay showed enhanced activity of PIMT in presence of all AuNSs, the maximum being with AuNS100. The efficacy of PIMT in presence of AuNS100 was further demonstrated by the reduction of fibrillation of Aβ42, the peptide that is implicated in Alzheimer's disease. The enhancement of anti-fibrillation activity of PIMT with AuNS100 was confirmed from cell survival assay with PC12 derived neuronal cells against Aβ42 induced neurotoxicity." @default.
• W3178159464 created "2021-07-19" @default.
• W3178159464 creator A5000031273 @default.
• W3178159464 creator A5034232864 @default.
• W3178159464 creator A5051532829 @default.
• W3178159464 creator A5090556582 @default.
• W3178159464 date "2021-07-12" @default.
• W3178159464 modified "2023-10-16" @default.
• W3178159464 title "Effect of gold nanoparticles on the structure and neuroprotective function of protein L-isoaspartyl methyltransferase (PIMT)" @default.
• W3178159464 cites W1101524764 @default.
• W3178159464 cites W1715632026 @default.
• W3178159464 cites W1771817923 @default.
• W3178159464 cites W1874005520 @default.
• W3178159464 cites W1944789189 @default.
• W3178159464 cites W1963745089 @default.
• W3178159464 cites W1966172363 @default.
• W3178159464 cites W1969699861 @default.
• W3178159464 cites W1969814828 @default.
• W3178159464 cites W1973681903 @default.
• W3178159464 cites W1977239238 @default.
• W3178159464 cites W1980893242 @default.
• W3178159464 cites W1991767480 @default.
• W3178159464 cites W1999364829 @default.
• W3178159464 cites W2008617358 @default.
• W3178159464 cites W2009562525 @default.
• W3178159464 cites W2010807691 @default.
• W3178159464 cites W2014369068 @default.
• W3178159464 cites W2014960272 @default.
• W3178159464 cites W2020418396 @default.
• W3178159464 cites W2055222641 @default.
• W3178159464 cites W2058587017 @default.
• W3178159464 cites W2063366729 @default.
• W3178159464 cites W2063375713 @default.
• W3178159464 cites W2064262345 @default.
• W3178159464 cites W2068972207 @default.
• W3178159464 cites W2071250190 @default.
• W3178159464 cites W2081808910 @default.
• W3178159464 cites W2085514791 @default.
• W3178159464 cites W2097242510 @default.
• W3178159464 cites W2109386523 @default.
• W3178159464 cites W2119017543 @default.
• W3178159464 cites W2125123295 @default.
• W3178159464 cites W2137335948 @default.
• W3178159464 cites W2144535585 @default.
• W3178159464 cites W2225755444 @default.
• W3178159464 cites W2264742377 @default.
• W3178159464 cites W2326418414 @default.
• W3178159464 cites W2588006844 @default.
• W3178159464 cites W2588637571 @default.
• W3178159464 cites W2749039461 @default.
• W3178159464 cites W2750507544 @default.
• W3178159464 cites W2777461679 @default.
• W3178159464 cites W2781987471 @default.
• W3178159464 cites W2793580812 @default.
• W3178159464 cites W2883135615 @default.
• W3178159464 cites W2884674899 @default.
• W3178159464 cites W2890134512 @default.
• W3178159464 cites W2909779745 @default.
• W3178159464 cites W2975801780 @default.
• W3178159464 cites W2990605027 @default.
• W3178159464 cites W3011802956 @default.
• W3178159464 doi "https://doi.org/10.1038/s41598-021-93752-1" @default.
• W3178159464 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8275801" @default.
• W3178159464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34253804" @default.
• W3178159464 hasPublicationYear "2021" @default.
• W3178159464 type Work @default.
• W3178159464 sameAs 3178159464 @default.
• W3178159464 citedByCount "8" @default.
• W3178159464 countsByYear W31781594642022 @default.
• W3178159464 countsByYear W31781594642023 @default.
• W3178159464 crossrefType "journal-article" @default.
• W3178159464 hasAuthorship W3178159464A5000031273 @default.
• W3178159464 hasAuthorship W3178159464A5034232864 @default.
• W3178159464 hasAuthorship W3178159464A5051532829 @default.
• W3178159464 hasAuthorship W3178159464A5090556582 @default.
• W3178159464 hasBestOaLocation W31781594641 @default.
• W3178159464 hasConcept C12554922 @default.
• W3178159464 hasConcept C126322002 @default.
• W3178159464 hasConcept C156911925 @default.
• W3178159464 hasConcept C185592680 @default.
• W3178159464 hasConcept C2777356233 @default.
• W3178159464 hasConcept C2779161974 @default.
• W3178159464 hasConcept C55493867 @default.
• W3178159464 hasConcept C71924100 @default.
• W3178159464 hasConcept C86803240 @default.
• W3178159464 hasConceptScore W3178159464C12554922 @default.
• W3178159464 hasConceptScore W3178159464C126322002 @default.
• W3178159464 hasConceptScore W3178159464C156911925 @default.
• W3178159464 hasConceptScore W3178159464C185592680 @default.
• W3178159464 hasConceptScore W3178159464C2777356233 @default.
• W3178159464 hasConceptScore W3178159464C2779161974 @default.
• W3178159464 hasConceptScore W3178159464C55493867 @default.
• W3178159464 hasConceptScore W3178159464C71924100 @default.
• W3178159464 hasConceptScore W3178159464C86803240 @default.
• W3178159464 hasIssue "1" @default.
• W3178159464 hasLocation W31781594641 @default.
• W3178159464 hasLocation W31781594642 @default.
• W3178159464 hasLocation W31781594643 @default.
• W3178159464 hasLocation W31781594644 @default.
• W3178159464 hasOpenAccess W3178159464 @default.

• next