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- W3178165042 endingPage "167154" @default.
- W3178165042 startingPage "167154" @default.
- W3178165042 abstract "After decades of progress in computational protein design, the design of proteins folding and functioning in lipid membranes appears today as the next frontier. Some notable successes in the de novo design of simplified model membrane protein systems have helped articulate fundamental principles of protein folding, architecture and interaction in the hydrophobic lipid environment. These principles are reviewed here, together with the computational methods and approaches that were used to identify them. We provide an overview of the methodological innovations in the generation of new protein structures and functions and in the development of membrane-specific energy functions. We highlight the opportunities offered by new machine learning approaches applied to protein design, and by new experimental characterization techniques applied to membrane proteins. Although membrane protein design is in its infancy, it appears more reachable than previously thought." @default.
- W3178165042 created "2021-07-19" @default.
- W3178165042 creator A5083456924 @default.
- W3178165042 date "2021-10-01" @default.
- W3178165042 modified "2023-10-16" @default.
- W3178165042 title "Principles and Methods in Computational Membrane Protein Design" @default.
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