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- W3178227008 abstract "Tetrodotoxin (TTX) is a potent neurotoxin found mainly in puffer fish and other marine and terrestrial animals. TTX blocks voltage-gated sodium channels (VGSCs) which are typically classified as TTX-sensitive or TTX-resistant channels. VGSCs play a key role in pain signaling and some TTX-sensitive VGSCs are highly expressed by adult primary sensory neurons. During pathological pain conditions, such as neuropathic pain, upregulation of some TTX-sensitive VGSCs, including the massive re-expression of the embryonic VGSC subtype NaV1.3 in adult primary sensory neurons, contribute to painful hypersensitization. In addition, people with loss-of-function mutations in the VGSC subtype NaV1.7 present congenital insensitive to pain. TTX displays a prominent analgesic effect in several models of neuropathic pain in rodents. According to this promising preclinical evidence, TTX is currently under clinical development for chemo-therapy-induced neuropathic pain and cancer-related pain. This review focuses primarily on the preclinical and clinical evidence that support a potential analgesic role for TTX in these pain states. In addition, we also analyze the main toxic effects that this neurotoxin produces when it is administered at therapeutic doses, and the therapeutic potential to alleviate neuropathic pain of other natural toxins that selectively block TTX-sensitive VGSCs." @default.
- W3178227008 created "2021-07-19" @default.
- W3178227008 creator A5012784469 @default.
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- W3178227008 creator A5061466379 @default.
- W3178227008 creator A5061963896 @default.
- W3178227008 creator A5067598878 @default.
- W3178227008 date "2021-07-12" @default.
- W3178227008 modified "2023-10-02" @default.
- W3178227008 title "Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief?" @default.
- W3178227008 cites W1543273438 @default.
- W3178227008 cites W1768063825 @default.
- W3178227008 cites W1798441007 @default.
- W3178227008 cites W1858165268 @default.
- W3178227008 cites W1965538993 @default.
- W3178227008 cites W1967441802 @default.
- W3178227008 cites W1986715632 @default.
- W3178227008 cites W2000178071 @default.
- W3178227008 cites W2004413159 @default.
- W3178227008 cites W2013256530 @default.
- W3178227008 cites W2024177131 @default.
- W3178227008 cites W2028993619 @default.
- W3178227008 cites W2031713143 @default.
- W3178227008 cites W2033072357 @default.
- W3178227008 cites W2034242115 @default.
- W3178227008 cites W2038050499 @default.
- W3178227008 cites W2039664528 @default.
- W3178227008 cites W2042741271 @default.
- W3178227008 cites W2043987721 @default.
- W3178227008 cites W2050750242 @default.
- W3178227008 cites W2056202757 @default.
- W3178227008 cites W2058882825 @default.
- W3178227008 cites W2064129686 @default.
- W3178227008 cites W2064401993 @default.
- W3178227008 cites W2070546766 @default.
- W3178227008 cites W2079521980 @default.
- W3178227008 cites W2081302012 @default.
- W3178227008 cites W2086690624 @default.
- W3178227008 cites W2089162374 @default.
- W3178227008 cites W2094779980 @default.
- W3178227008 cites W2104818454 @default.
- W3178227008 cites W2114176091 @default.
- W3178227008 cites W2126246278 @default.
- W3178227008 cites W2127894556 @default.
- W3178227008 cites W2128741370 @default.
- W3178227008 cites W2132589158 @default.
- W3178227008 cites W2135849985 @default.
- W3178227008 cites W2137628251 @default.
- W3178227008 cites W2139306343 @default.
- W3178227008 cites W2142362544 @default.
- W3178227008 cites W2149318383 @default.
- W3178227008 cites W2149599746 @default.
- W3178227008 cites W2151325894 @default.
- W3178227008 cites W2151482650 @default.
- W3178227008 cites W2155524482 @default.
- W3178227008 cites W2156255142 @default.
- W3178227008 cites W2169883815 @default.
- W3178227008 cites W2284441384 @default.
- W3178227008 cites W2292128710 @default.
- W3178227008 cites W2337210803 @default.
- W3178227008 cites W2399987572 @default.
- W3178227008 cites W2412769083 @default.
- W3178227008 cites W2465001507 @default.
- W3178227008 cites W2589488000 @default.
- W3178227008 cites W2592082383 @default.
- W3178227008 cites W2595241355 @default.
- W3178227008 cites W2606254225 @default.
- W3178227008 cites W2610210672 @default.
- W3178227008 cites W2618712452 @default.
- W3178227008 cites W2638093340 @default.
- W3178227008 cites W2741918516 @default.
- W3178227008 cites W2758525179 @default.
- W3178227008 cites W2779347386 @default.
- W3178227008 cites W2802748604 @default.
- W3178227008 cites W2802836296 @default.
- W3178227008 cites W2805437712 @default.
- W3178227008 cites W2806706572 @default.
- W3178227008 cites W2903653527 @default.
- W3178227008 cites W2906123225 @default.
- W3178227008 cites W2912762225 @default.
- W3178227008 cites W2922571874 @default.
- W3178227008 cites W2935900103 @default.
- W3178227008 cites W2936355305 @default.
- W3178227008 cites W2943352432 @default.
- W3178227008 cites W2943481209 @default.
- W3178227008 cites W2944832040 @default.
- W3178227008 cites W2947586542 @default.
- W3178227008 cites W2981849470 @default.
- W3178227008 cites W2983233408 @default.
- W3178227008 cites W2983456631 @default.
- W3178227008 cites W2984726587 @default.
- W3178227008 cites W2990820349 @default.
- W3178227008 cites W2992421845 @default.
- W3178227008 cites W2996895051 @default.
- W3178227008 cites W2998637557 @default.
- W3178227008 cites W3008638582 @default.
- W3178227008 cites W3015546232 @default.