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- W3178282439 abstract "Apigenin (APG), a natural bioactive flavonoid has multiple pharmacological effects. However, its poor aqueous solubility hinders its clinical benefits.The work aimed to develop novel apigenin-loaded niosomes (APG-NIO) with ecological probe sonication techniques. The formulation was statistically optimized by Box-Behnken design (BBD) and the independent variables were selected as Span 80(X1), Poloxamer 188(X2), and Tween 80(X3) at three levels, and the dependent variables were identified as: particle size (Y1), polydispersity index (Y2), and % entrapment efficiency (Y3). The formulation was characterized for various parameters such as vesicle shape, size, PDI, %EE, solubility, in vitro drug release, and antioxidant potential.The optimized APG-NIO formulation was found to have a spherical shape with homogenous distribution and a low polydispersity index. It has a particle size of 425.77 nm, zeta potential -17.1±0.9 mV, and % EE of 89.63. The aqueous solubility of APG-NIO was found approximately 45 times higher than that of pure APG. The formulation showed a higher drug release rate as compared to pure APG in phosphate buffer pH 7.4 and followed the Higuchi release model with a non-Fickian transport mechanism. The stability was found at 4°C for 3 months. The antioxidant potential of APG-NIO was significantly increased in comparison to the pure drug suspension in the DPPH• assay.These findings suggest that the probe sonication technique is an alternative, cost-effective, simple, and green method for the development of niosomes, and BBD is a useful optimization tool for identifying the effect of formulation variables." @default.
- W3178282439 created "2021-07-19" @default.
- W3178282439 creator A5085019268 @default.
- W3178282439 date "2022-02-25" @default.
- W3178282439 modified "2023-09-28" @default.
- W3178282439 title "Development of Apigenin-Loaded Niosomes Using Ecological Probe Sonication Technique for Enhanced Oral Delivery: Application of Box- Behnken Design" @default.
- W3178282439 doi "https://doi.org/10.2174/1389201022666210709143525" @default.
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