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• W3178291870 abstract "Abstract Synchronous neurotransmission is central to efficient information transfer in neural circuits, requiring precise coupling between action potentials, Ca 2+ entry and neurotransmitter release. However, determinations of Ca 2+ requirements for release, which may originate from entry through single voltage-gated Ca 2+ channels, remain largely unexplored in simple active zone synapses common in the nervous system. Understanding these requirements is key to addressing Ca 2+ channel and synaptic dysfunction underlying numerous neurological and neuropsychiatric disorders. Here, we present single channel analysis of evoked active zone Ca 2+ entry, using cell-attached patch clamp and lattice light sheet microscopy over active zones at single central lamprey reticulospinal presynaptic terminals. Our findings show a small pool (mean of 23) of Ca 2+ channels at each terminal, comprising subtypes N-type (CaV2.2), P/Q-type (CaV2.1) and R-type (CaV2.3), available to gate neurotransmitter release. Significantly, of this pool only 1-6 (mean of 4) channels open upon depolarization. High temporal fidelity lattice light sheet imaging reveals AP-evoked Ca 2+ transients exhibiting quantal amplitude variations between action potentials and stochastic variation of precise locations of Ca 2+ entry within the active zone. Further, Ca 2+ channel numbers at each active zone correlate to the number of presynaptic primed synaptic vesicles. Together, our findings indicate 1:1 association of Ca 2+ channels with primed vesicles, suggesting Ca 2+ entry via as few as one channel may trigger neurotransmitter release." @default.
• W3178291870 created "2021-07-19" @default.
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• W3178291870 date "2021-02-02" @default.
• W3178291870 modified "2023-10-15" @default.
• W3178291870 title "Single calcium channel nanodomains drive presynaptic calcium entry at lamprey reticulospinal presynaptic terminals" @default.
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• W3178291870 doi "https://doi.org/10.1101/2021.02.02.429388" @default.
• W3178291870 hasPublicationYear "2021" @default.
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