FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178353502> ?p ?o ?g. }

• W3178353502 abstract "Glutaminolysis is known to correlate with ovarian cancer aggressiveness and invasion. However, how this affects the tumor microenvironment is elusive. Here, we show that ovarian cancer cells become addicted to extracellular glutamine when silenced for glutamine synthetase (GS), similar to naturally occurring GS-low, glutaminolysis-high ovarian cancer cells. Glutamine addiction elicits a crosstalk mechanism whereby cancer cells release N-acetylaspartate (NAA) which, through the inhibition of the NMDA receptor, and synergistically with IL-10, enforces GS expression in macrophages. In turn, GS-high macrophages acquire M2-like, tumorigenic features. Supporting this in␣vitro model, in silico data and the analysis of ascitic fluid isolated from ovarian cancer patients prove that an M2-like macrophage phenotype, IL-10 release, and NAA levels positively correlate with disease stage. Our study uncovers the unprecedented role of glutamine metabolism in modulating macrophage polarization in highly invasive ovarian cancer and highlights the anti-inflammatory, protumoral function of NAA." @default.
• W3178353502 created "2021-07-19" @default.
• W3178353502 creator A5000419816 @default.
• W3178353502 creator A5004186145 @default.
• W3178353502 creator A5004761260 @default.
• W3178353502 creator A5008900182 @default.
• W3178353502 creator A5013403063 @default.
• W3178353502 creator A5033985207 @default.
• W3178353502 creator A5034703359 @default.
• W3178353502 creator A5048379138 @default.
• W3178353502 creator A5059092343 @default.
• W3178353502 creator A5059262748 @default.
• W3178353502 creator A5070361761 @default.
• W3178353502 creator A5071762237 @default.
• W3178353502 creator A5081131425 @default.
• W3178353502 creator A5082256230 @default.
• W3178353502 creator A5084655443 @default.
• W3178353502 creator A5086283047 @default.
• W3178353502 date "2021-07-14" @default.
• W3178353502 modified "2023-10-18" @default.
• W3178353502 title "<i>N</i> ‐acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages" @default.
• W3178353502 cites W1964052519 @default.
• W3178353502 cites W1982330633 @default.
• W3178353502 cites W1984363265 @default.
• W3178353502 cites W1990129735 @default.
• W3178353502 cites W1991066138 @default.
• W3178353502 cites W1993038196 @default.
• W3178353502 cites W1998757074 @default.
• W3178353502 cites W2016651165 @default.
• W3178353502 cites W2034101077 @default.
• W3178353502 cites W2041358992 @default.
• W3178353502 cites W2041535807 @default.
• W3178353502 cites W2048184399 @default.
• W3178353502 cites W2051181260 @default.
• W3178353502 cites W2054129051 @default.
• W3178353502 cites W2054771256 @default.
• W3178353502 cites W2060592426 @default.
• W3178353502 cites W2074873270 @default.
• W3178353502 cites W2090406819 @default.
• W3178353502 cites W2095447700 @default.
• W3178353502 cites W2096489574 @default.
• W3178353502 cites W2097103399 @default.
• W3178353502 cites W2100672151 @default.
• W3178353502 cites W2102118295 @default.
• W3178353502 cites W2103281302 @default.
• W3178353502 cites W2116516144 @default.
• W3178353502 cites W2117398821 @default.
• W3178353502 cites W2120251063 @default.
• W3178353502 cites W2123696077 @default.
• W3178353502 cites W2127624416 @default.
• W3178353502 cites W2141517721 @default.
• W3178353502 cites W2150333097 @default.
• W3178353502 cites W2152865860 @default.
• W3178353502 cites W2157230165 @default.
• W3178353502 cites W2158390744 @default.
• W3178353502 cites W2159550690 @default.
• W3178353502 cites W2162454135 @default.
• W3178353502 cites W2165279893 @default.
• W3178353502 cites W2169903226 @default.
• W3178353502 cites W2179520978 @default.
• W3178353502 cites W2184384535 @default.
• W3178353502 cites W2227392755 @default.
• W3178353502 cites W2272992156 @default.
• W3178353502 cites W2300605759 @default.
• W3178353502 cites W2319385595 @default.
• W3178353502 cites W2326237820 @default.
• W3178353502 cites W2328936438 @default.
• W3178353502 cites W2343668821 @default.
• W3178353502 cites W2402832543 @default.
• W3178353502 cites W2416380723 @default.
• W3178353502 cites W2582217148 @default.
• W3178353502 cites W2590999072 @default.
• W3178353502 cites W2597637198 @default.
• W3178353502 cites W2747888169 @default.
• W3178353502 cites W2754546465 @default.
• W3178353502 cites W2766550318 @default.
• W3178353502 cites W2770731691 @default.
• W3178353502 cites W2788131326 @default.
• W3178353502 cites W2810469960 @default.
• W3178353502 cites W2891368386 @default.
• W3178353502 cites W2906615764 @default.
• W3178353502 cites W2942610007 @default.
• W3178353502 cites W2947554843 @default.
• W3178353502 cites W2989074685 @default.
• W3178353502 cites W3027286012 @default.
• W3178353502 cites W3036895040 @default.
• W3178353502 cites W3083061001 @default.
• W3178353502 cites W3085136029 @default.
• W3178353502 cites W3095074479 @default.
• W3178353502 cites W3178353502 @default.
• W3178353502 cites W4232874707 @default.
• W3178353502 doi "https://doi.org/10.15252/embr.202051981" @default.
• W3178353502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8419692" @default.
• W3178353502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34260142" @default.
• W3178353502 hasPublicationYear "2021" @default.
• W3178353502 type Work @default.
• W3178353502 sameAs 3178353502 @default.
• W3178353502 citedByCount "19" @default.
• W3178353502 countsByYear W31783535022021 @default.
• W3178353502 countsByYear W31783535022022 @default.

• next