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- W3178382808 startingPage "106035" @default.
- W3178382808 abstract "• The PE/PPE proteins of Mycobacterium tuberculosis are potential virulent factors and have important role in tuberculosis pathogenesis. • The pe/ppe genes have co-evolved with ESX secretion system and are regulated by an intricate network of heterogeneous transcription factors. • Mtb cell surface localized PE/PPE proteins mediate host-pathogen interaction. • These proteins are excellent modulators of host immune response and help in persistence of pathogen. • Huge repertoire of antigenic epitopes of these proteins makes them potential vaccine candidates. The PE/PPE proteins encoded by seven percent (7%) of Mycobacterium tuberculosis (Mtb) genome are the chief constituents to pathogen's virulence reservoir. The fact that these genes have evolved along ESX secretory system in pathogenic Mtb strains make their investigation very intriguing. There is lot of speculation about the prominent role of these proteins at host pathogen interface and in disease pathogenesis. Nevertheless, the exact function of PE/PPE proteins still remains a mystery which calls for further research targeting these proteins. This article is an effort to document all the facts known so far with regard to these unique proteins which involves their origin, evolution, transcriptional control, and most important their role as host immune-modulators. Our understanding strongly points towards the versatile nature of these PE/PPE proteins as Mtb's host immune sensors and as decisive factors in shaping the outcome of infection. Further investigation on these proteins will surely pave way for newer and effective vaccines and therapeutics to control Tuberculosis (TB)." @default.
- W3178382808 created "2021-07-19" @default.
- W3178382808 creator A5004432549 @default.
- W3178382808 creator A5051433263 @default.
- W3178382808 creator A5051728860 @default.
- W3178382808 date "2021-10-01" @default.
- W3178382808 modified "2023-10-18" @default.
- W3178382808 title "Proline-Glutamate/Proline-Proline-Glutamate (PE/PPE) proteins of Mycobacterium tuberculosis: The multifaceted immune-modulators" @default.
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