Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178393457> ?p ?o ?g. }
- W3178393457 endingPage "659" @default.
- W3178393457 startingPage "641" @default.
- W3178393457 abstract "Abstract The price of the currently best available antimalarial treatment is driven in large part by the limited availability of its base drug compound artemisinin. One approach to reduce the artemisinin cost is to efficiently integrate the partial synthesis of artemisinin starting from its biological precursor dihydroartemisinic acid (DHAA) into the production process. The optimal design of such an integrated process is a complex task that is easier to solve through simulations studies and process modelling. In this article, we present a quantitative kinetic model for the photooxygenation of DHAA to an hydroperoxide, the essential initial step of the partial synthesis to artemisinin. The photooxygenation reactions were studied in a two-phase photo-flow reactor utilizing Taylor flow for enhanced mixing and fast gas-liquid mass transfer. A good agreement of the model and the experimental data was achieved for all combinations of photosensitizer concentration, photon flux, fluid velocity and both liquid and gas phase compositions. Deviations between simulated predictions and measurements for the amount of hydroperoxide formed are 7.1 % on average. Consequently, the identified and parameterized kinetic model is exploited to investigate different behaviors of the reactor under study. In a final step, the kinetic model is utilized to suggest attractive operating windows for future applications of the photooxygenation of DHAA exploiting reaction rates that are not affected by mass transfer limitations." @default.
- W3178393457 created "2021-07-19" @default.
- W3178393457 creator A5009392231 @default.
- W3178393457 creator A5017377950 @default.
- W3178393457 creator A5024721296 @default.
- W3178393457 creator A5041495007 @default.
- W3178393457 creator A5054981549 @default.
- W3178393457 creator A5077807060 @default.
- W3178393457 creator A5086300394 @default.
- W3178393457 date "2021-07-13" @default.
- W3178393457 modified "2023-09-27" @default.
- W3178393457 title "Kinetic analysis of the partial synthesis of artemisinin: Photooxygenation to the intermediate hydroperoxide" @default.
- W3178393457 cites W1838092288 @default.
- W3178393457 cites W1901553221 @default.
- W3178393457 cites W1967147239 @default.
- W3178393457 cites W1971513325 @default.
- W3178393457 cites W1975485068 @default.
- W3178393457 cites W1981472507 @default.
- W3178393457 cites W1984156465 @default.
- W3178393457 cites W1985572431 @default.
- W3178393457 cites W1990226486 @default.
- W3178393457 cites W1994695086 @default.
- W3178393457 cites W2012480602 @default.
- W3178393457 cites W2019758240 @default.
- W3178393457 cites W2020473715 @default.
- W3178393457 cites W2020814578 @default.
- W3178393457 cites W2021616963 @default.
- W3178393457 cites W2031301541 @default.
- W3178393457 cites W2035045727 @default.
- W3178393457 cites W2036407535 @default.
- W3178393457 cites W2041332307 @default.
- W3178393457 cites W2041676947 @default.
- W3178393457 cites W2051964194 @default.
- W3178393457 cites W2060160295 @default.
- W3178393457 cites W2062197582 @default.
- W3178393457 cites W2080053579 @default.
- W3178393457 cites W2088440295 @default.
- W3178393457 cites W2092975699 @default.
- W3178393457 cites W2098205015 @default.
- W3178393457 cites W2101254053 @default.
- W3178393457 cites W2112793143 @default.
- W3178393457 cites W2121676685 @default.
- W3178393457 cites W2124531971 @default.
- W3178393457 cites W2149202606 @default.
- W3178393457 cites W2155949509 @default.
- W3178393457 cites W2156652499 @default.
- W3178393457 cites W2159324125 @default.
- W3178393457 cites W2163971082 @default.
- W3178393457 cites W2166384326 @default.
- W3178393457 cites W2167284483 @default.
- W3178393457 cites W2168648059 @default.
- W3178393457 cites W2279324833 @default.
- W3178393457 cites W2317120704 @default.
- W3178393457 cites W2329391962 @default.
- W3178393457 cites W2473599700 @default.
- W3178393457 cites W2504159405 @default.
- W3178393457 cites W2552635486 @default.
- W3178393457 cites W2768809684 @default.
- W3178393457 cites W2789689307 @default.
- W3178393457 cites W2791194469 @default.
- W3178393457 cites W2797842077 @default.
- W3178393457 cites W2885558332 @default.
- W3178393457 cites W2903272415 @default.
- W3178393457 cites W2905486571 @default.
- W3178393457 cites W2922005527 @default.
- W3178393457 cites W2949859856 @default.
- W3178393457 cites W2951491367 @default.
- W3178393457 cites W2952602153 @default.
- W3178393457 cites W2997550633 @default.
- W3178393457 cites W3007056523 @default.
- W3178393457 cites W3008261616 @default.
- W3178393457 cites W3024845009 @default.
- W3178393457 cites W3033875363 @default.
- W3178393457 cites W4243183814 @default.
- W3178393457 cites W4255724519 @default.
- W3178393457 doi "https://doi.org/10.1007/s41981-021-00181-2" @default.
- W3178393457 hasPublicationYear "2021" @default.
- W3178393457 type Work @default.
- W3178393457 sameAs 3178393457 @default.
- W3178393457 citedByCount "2" @default.
- W3178393457 countsByYear W31783934572022 @default.
- W3178393457 countsByYear W31783934572023 @default.
- W3178393457 crossrefType "journal-article" @default.
- W3178393457 hasAuthorship W3178393457A5009392231 @default.
- W3178393457 hasAuthorship W3178393457A5017377950 @default.
- W3178393457 hasAuthorship W3178393457A5024721296 @default.
- W3178393457 hasAuthorship W3178393457A5041495007 @default.
- W3178393457 hasAuthorship W3178393457A5054981549 @default.
- W3178393457 hasAuthorship W3178393457A5077807060 @default.
- W3178393457 hasAuthorship W3178393457A5086300394 @default.
- W3178393457 hasBestOaLocation W31783934571 @default.
- W3178393457 hasConcept C121332964 @default.
- W3178393457 hasConcept C132482357 @default.
- W3178393457 hasConcept C135889238 @default.
- W3178393457 hasConcept C161790260 @default.
- W3178393457 hasConcept C178790620 @default.
- W3178393457 hasConcept C185592680 @default.
- W3178393457 hasConcept C203014093 @default.