FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178396149> ?p ?o ?g. }

• W3178396149 abstract "Abstract Background Lysine 2-hydroxyisobutyrylation (K hib ) is a newly discovered protein posttranslational modification (PTM) and is involved in the broad-spectrum regulation of cellular processes that are found in both prokaryotic and eukaryotic cells, including in plants. The Chinese herb rhubarb (Dahuang) is one of the most widely used traditional Chinese medicines in clinical applications. To better understand the physiological activities and mechanism of treating diseases with the herb, it is necessary to conduct intensive research on rhubarb. However, K hib modification has not been reported thus far in rhubarb. Results In this study, we performed the first global analysis of K hib -modified proteins in rhubarb by using sensitive affinity enrichment combined with high-accuracy HPLC-MS/MS tandem spectrometry. A total of 4333 overlapping K hib modification peptides matched on 1525 K hib -containing proteins were identified in three independent tests. Bioinformatics analysis showed that these K hib -containing proteins are involved in a wide range of cellular processes, particularly in protein biosynthesis and central carbon metabolism and are distributed mainly in chloroplasts, cytoplasm, nucleus and mitochondria. In addition, the amino acid sequence motif analysis showed that a negatively charged side chain residue (E), a positively charged residue (K), and an uncharged residue with the smallest side chain (G) were strongly preferred around the K hib site, and a total of 13 K hib modification motifs were identified. These identified motifs can be classified into three motif patterns, and some motif patterns are unique to rhubarb and have not been identified in other plants to date. Conclusions A total of 4333 K hib -modified peptides on 1525 proteins were identified. The K hib -modified proteins are mainly distributed in the chloroplast, cytoplasm, nucleus and mitochondria, and involved in a wide range of cellular processes. Moreover, three types of amino acid sequence motif patterns, including EK hib /K hib E, GK hib and k.kkk….K hib ….kkkkk, were extracted from a total of 13 K hib -modified peptides. This study provides comprehensive K hib -proteome resource of rhubarb. The findings from the study contribute to a better understanding of the physiological roles of K hib modification, and the K hib proteome data will facilitate further investigations of the roles and mechanisms of K hib modification in rhubarb." @default.
• W3178396149 created "2021-07-19" @default.
• W3178396149 creator A5001998362 @default.
• W3178396149 creator A5018523807 @default.
• W3178396149 creator A5032245741 @default.
• W3178396149 creator A5048226585 @default.
• W3178396149 creator A5057664014 @default.
• W3178396149 creator A5085999199 @default.
• W3178396149 date "2021-07-15" @default.
• W3178396149 modified "2023-10-10" @default.
• W3178396149 title "Global analysis of protein lysine 2-hydroxyisobutyrylation (Khib) profiles in Chinese herb rhubarb (Dahuang)" @default.
• W3178396149 cites W1571090306 @default.
• W3178396149 cites W1987805766 @default.
• W3178396149 cites W1995454576 @default.
• W3178396149 cites W2011198641 @default.
• W3178396149 cites W2028161249 @default.
• W3178396149 cites W2028938598 @default.
• W3178396149 cites W2046301798 @default.
• W3178396149 cites W2103017472 @default.
• W3178396149 cites W2115862579 @default.
• W3178396149 cites W2253486751 @default.
• W3178396149 cites W2282638223 @default.
• W3178396149 cites W2329881077 @default.
• W3178396149 cites W2398560682 @default.
• W3178396149 cites W2409007332 @default.
• W3178396149 cites W2573652931 @default.
• W3178396149 cites W2740419787 @default.
• W3178396149 cites W2767231150 @default.
• W3178396149 cites W2774442672 @default.
• W3178396149 cites W2774906913 @default.
• W3178396149 cites W2781959102 @default.
• W3178396149 cites W2803484505 @default.
• W3178396149 cites W2952973737 @default.
• W3178396149 cites W2956607802 @default.
• W3178396149 cites W2971719780 @default.
• W3178396149 cites W3028065870 @default.
• W3178396149 cites W3036073033 @default.
• W3178396149 cites W3080830213 @default.
• W3178396149 cites W3084410714 @default.
• W3178396149 cites W4294216483 @default.
• W3178396149 doi "https://doi.org/10.1186/s12864-021-07847-0" @default.
• W3178396149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8283887" @default.
• W3178396149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34266380" @default.
• W3178396149 hasPublicationYear "2021" @default.
• W3178396149 type Work @default.
• W3178396149 sameAs 3178396149 @default.
• W3178396149 citedByCount "5" @default.
• W3178396149 countsByYear W31783961492022 @default.
• W3178396149 countsByYear W31783961492023 @default.
• W3178396149 crossrefType "journal-article" @default.
• W3178396149 hasAuthorship W3178396149A5001998362 @default.
• W3178396149 hasAuthorship W3178396149A5018523807 @default.
• W3178396149 hasAuthorship W3178396149A5032245741 @default.
• W3178396149 hasAuthorship W3178396149A5048226585 @default.
• W3178396149 hasAuthorship W3178396149A5057664014 @default.
• W3178396149 hasAuthorship W3178396149A5085999199 @default.
• W3178396149 hasBestOaLocation W31783961491 @default.
• W3178396149 hasConcept C104317684 @default.
• W3178396149 hasConcept C117745874 @default.
• W3178396149 hasConcept C162356407 @default.
• W3178396149 hasConcept C185592680 @default.
• W3178396149 hasConcept C190062978 @default.
• W3178396149 hasConcept C2776016237 @default.
• W3178396149 hasConcept C2781338088 @default.
• W3178396149 hasConcept C31827203 @default.
• W3178396149 hasConcept C43617362 @default.
• W3178396149 hasConcept C46111723 @default.
• W3178396149 hasConcept C515207424 @default.
• W3178396149 hasConcept C54355233 @default.
• W3178396149 hasConcept C55493867 @default.
• W3178396149 hasConcept C70721500 @default.
• W3178396149 hasConcept C86803240 @default.
• W3178396149 hasConceptScore W3178396149C104317684 @default.
• W3178396149 hasConceptScore W3178396149C117745874 @default.
• W3178396149 hasConceptScore W3178396149C162356407 @default.
• W3178396149 hasConceptScore W3178396149C185592680 @default.
• W3178396149 hasConceptScore W3178396149C190062978 @default.
• W3178396149 hasConceptScore W3178396149C2776016237 @default.
• W3178396149 hasConceptScore W3178396149C2781338088 @default.
• W3178396149 hasConceptScore W3178396149C31827203 @default.
• W3178396149 hasConceptScore W3178396149C43617362 @default.
• W3178396149 hasConceptScore W3178396149C46111723 @default.
• W3178396149 hasConceptScore W3178396149C515207424 @default.
• W3178396149 hasConceptScore W3178396149C54355233 @default.
• W3178396149 hasConceptScore W3178396149C55493867 @default.
• W3178396149 hasConceptScore W3178396149C70721500 @default.
• W3178396149 hasConceptScore W3178396149C86803240 @default.
• W3178396149 hasIssue "1" @default.
• W3178396149 hasLocation W31783961491 @default.
• W3178396149 hasLocation W31783961492 @default.
• W3178396149 hasOpenAccess W3178396149 @default.
• W3178396149 hasPrimaryLocation W31783961491 @default.
• W3178396149 hasRelatedWork W10489064 @default.
• W3178396149 hasRelatedWork W1991523530 @default.
• W3178396149 hasRelatedWork W2002128513 @default.
• W3178396149 hasRelatedWork W2024103894 @default.
• W3178396149 hasRelatedWork W2070798416 @default.
• W3178396149 hasRelatedWork W2135713595 @default.
• W3178396149 hasRelatedWork W2171277769 @default.
• W3178396149 hasRelatedWork W2404125762 @default.

• next