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- W3178403558 abstract "Summary/Abstract Bacteriophages (phages) are diverse and abundant constituents of microbial communities worldwide, and are capable of modulating bacterial populations in diverse ways. Here we describe a novel phage, ϕHNL01, which infects the marine bacterium Vibrio fischeri . We use culture-based approaches to demonstrate that mutations in the exopolysaccharide locus of V. fischeri render this bacterium resistant to infection by ϕHNL01, highlighting the extracellular matrix as a key determinant of phage tropism in this interaction. Additionally, using the natural symbiosis between V. fischeri and the squid Euprymna scolopes , we show that during colonization, V. fischeri is protected from phage present in the ambient seawater. Taken together, these findings shed light on independent yet synergistic host- and bacterium-based strategies for resisting symbiosis-disrupting phage predation, and present important implications for understanding these strategies in the context of host-associated microbial ecosystems." @default.
- W3178403558 created "2021-07-19" @default.
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- W3178403558 date "2021-07-10" @default.
- W3178403558 modified "2023-10-03" @default.
- W3178403558 title "Independent host- and bacterium-based determinants protect a model symbiosis from phage predation" @default.
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- W3178403558 doi "https://doi.org/10.1101/2021.07.09.451802" @default.
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