Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178542415> ?p ?o ?g. }
- W3178542415 endingPage "3466" @default.
- W3178542415 startingPage "3466" @default.
- W3178542415 abstract "Solid cancer progression is dictated by neoplastic cell features and pro-tumoral crosstalks with their microenvironment. Stroma modifications, such as fibroblast activation into cancer-associated fibroblasts (CAFs) and extracellular matrix (ECM) remodeling, are now recognized as critical events for cancer progression and as potential therapeutic or diagnostic targets. The recent appreciation of the key, complex and multiple roles of the ECM in cancer and of the CAF diversity, has revolutionized the field and raised innovative but challenging questions. Here, we rapidly present CAF heterogeneity in link with their specific ECM remodeling features observed in cancer, before developing each of the impacts of such ECM modifications on tumor progression (survival, angiogenesis, pre-metastatic niche, chemoresistance, etc.), and on patient prognosis. Finally, based on preclinical studies and recent results obtained from clinical trials, we highlight key mechanisms or proteins that are, or may be, used as potential therapeutic or diagnostic targets, and we report and discuss benefits, disappointments, or even failures, of recently reported stroma-targeting strategies." @default.
- W3178542415 created "2021-07-19" @default.
- W3178542415 creator A5024798692 @default.
- W3178542415 creator A5049731648 @default.
- W3178542415 creator A5061218399 @default.
- W3178542415 creator A5078518284 @default.
- W3178542415 creator A5081798004 @default.
- W3178542415 date "2021-07-11" @default.
- W3178542415 modified "2023-10-18" @default.
- W3178542415 title "Extracellular Matrices and Cancer-Associated Fibroblasts: Targets for Cancer Diagnosis and Therapy?" @default.
- W3178542415 cites W137677171 @default.
- W3178542415 cites W1428077152 @default.
- W3178542415 cites W1497915798 @default.
- W3178542415 cites W1510384544 @default.
- W3178542415 cites W1516077090 @default.
- W3178542415 cites W1538274695 @default.
- W3178542415 cites W1593844282 @default.
- W3178542415 cites W1601681275 @default.
- W3178542415 cites W1702289223 @default.
- W3178542415 cites W1723444490 @default.
- W3178542415 cites W1734622341 @default.
- W3178542415 cites W1762620449 @default.
- W3178542415 cites W1808710027 @default.
- W3178542415 cites W1808819173 @default.
- W3178542415 cites W1844836761 @default.
- W3178542415 cites W1855871243 @default.
- W3178542415 cites W1890402826 @default.
- W3178542415 cites W1910308666 @default.
- W3178542415 cites W1919685122 @default.
- W3178542415 cites W1950118853 @default.
- W3178542415 cites W1965001670 @default.
- W3178542415 cites W1965358479 @default.
- W3178542415 cites W1965498876 @default.
- W3178542415 cites W1966551238 @default.
- W3178542415 cites W1966695696 @default.
- W3178542415 cites W1969628829 @default.
- W3178542415 cites W1971627258 @default.
- W3178542415 cites W1972135632 @default.
- W3178542415 cites W1972325477 @default.
- W3178542415 cites W1973147485 @default.
- W3178542415 cites W1976026714 @default.
- W3178542415 cites W1976221853 @default.
- W3178542415 cites W1976762025 @default.
- W3178542415 cites W1976992968 @default.
- W3178542415 cites W1977381126 @default.
- W3178542415 cites W1979990833 @default.
- W3178542415 cites W1980542313 @default.
- W3178542415 cites W1982066003 @default.
- W3178542415 cites W1982865160 @default.
- W3178542415 cites W1984483611 @default.
- W3178542415 cites W1985727076 @default.
- W3178542415 cites W1986103964 @default.
- W3178542415 cites W1986998583 @default.
- W3178542415 cites W1987929298 @default.
- W3178542415 cites W1988470533 @default.
- W3178542415 cites W1991707690 @default.
- W3178542415 cites W1992128774 @default.
- W3178542415 cites W1992280242 @default.
- W3178542415 cites W1992461278 @default.
- W3178542415 cites W1992636050 @default.
- W3178542415 cites W1995910380 @default.
- W3178542415 cites W1996474536 @default.
- W3178542415 cites W1996912024 @default.
- W3178542415 cites W1999600810 @default.
- W3178542415 cites W2000315116 @default.
- W3178542415 cites W2002689409 @default.
- W3178542415 cites W2002708019 @default.
- W3178542415 cites W2003921795 @default.
- W3178542415 cites W2004976275 @default.
- W3178542415 cites W2005334224 @default.
- W3178542415 cites W2006628284 @default.
- W3178542415 cites W2007052191 @default.
- W3178542415 cites W2007099293 @default.
- W3178542415 cites W2008189345 @default.
- W3178542415 cites W2011953153 @default.
- W3178542415 cites W2013322971 @default.
- W3178542415 cites W2014603723 @default.
- W3178542415 cites W2014862542 @default.
- W3178542415 cites W2014915378 @default.
- W3178542415 cites W2015509667 @default.
- W3178542415 cites W2015724236 @default.
- W3178542415 cites W2016650805 @default.
- W3178542415 cites W2018702739 @default.
- W3178542415 cites W2019155872 @default.
- W3178542415 cites W2019922483 @default.
- W3178542415 cites W2020866377 @default.
- W3178542415 cites W2021391221 @default.
- W3178542415 cites W2022718682 @default.
- W3178542415 cites W2023026872 @default.
- W3178542415 cites W2024818970 @default.
- W3178542415 cites W2025036947 @default.
- W3178542415 cites W2026274081 @default.
- W3178542415 cites W2028327679 @default.
- W3178542415 cites W2028850312 @default.
- W3178542415 cites W2030199762 @default.
- W3178542415 cites W2030605936 @default.
- W3178542415 cites W2030864157 @default.
- W3178542415 cites W2031856001 @default.