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- W3178593938 abstract "Titanium-based orthopaedic/dental implants modified with various metal-doping strategies can enhance local therapy and bioactivity. Intentional or unintentional (because of loading and wear) release of metal ions/nanoparticles (NPs) from metal-doped implants can be therapeutic or cause adverse local tissue reactions, compromising long-term survival. Strategies to incorporate metals into implants, such as superficial or deep loading inside nano-engineered surfaces, including nanotubes, and the physiochemical characteristics of the released species significantly influence both their therapeutic and cytotoxic potential. In this review, we compare and contrast this 'double-edged sword' to arrive at an improved understanding of metal-doped implants to enable controlled therapy while minimising cytotoxicity concerns." @default.
- W3178593938 created "2021-07-19" @default.
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- W3178593938 date "2021-11-01" @default.
- W3178593938 modified "2023-10-18" @default.
- W3178593938 title "Double-edged sword: Therapeutic efficacy versus toxicity evaluations of doped titanium implants" @default.
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- W3178593938 doi "https://doi.org/10.1016/j.drudis.2021.07.004" @default.
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