FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178611553> ?p ?o ?g. }

• W3178611553 endingPage "4194" @default.
• W3178611553 startingPage "4178" @default.
• W3178611553 abstract "Traditional statistical techniques for extrapolating short-term survival data for anticancer therapies assume the same mortality rate for noncured and cured patients, which is appropriate for projecting survival of non-curative therapies but may lead to an underestimation of the treatment effectiveness for potentially curative therapies. Our objective was to ascertain research trends in survival extrapolation techniques used to project the survival benefits of chimeric antigen receptor T cell (CAR-T) therapies.A global systematic literature search produced a review of survival analyses of CAR-T therapies, published between January 1, 2015 and December 14, 2020, based on publications sourced from MEDLINE, scientific conferences, and health technology assessment agencies. Trends in survival extrapolation techniques used, and the rationale for selecting advanced techniques, are discussed.Twenty publications were included, the majority of which (65%, N = 13) accounted for curative intent of CAR-T therapies through the use of advanced extrapolation techniques, i.e., mixture cure models [MCMs] (N = 10) or spline-based models (N = 3). The authors' rationale for using the MCM approach included (a) better statistical fits to the observed Kaplan-Meier curves (KMs) and (b) visual inspection of the KMs indicated that a proportion of patients experienced long-term remission and survival which is not inherently captured in standard parametric distributions.Our findings suggest that an advanced extrapolation technique should be considered in base case survival analyses of CAR-T therapies when extrapolating short-term survival data to long-term horizons extending beyond the clinical trial duration.Advanced extrapolation techniques allow researchers to account for the proportion of patients with an observed plateau in survival from clinical trial data; by only using standard-partitioned modeling, researchers may risk underestimating the survival benefits for the subset of patients with long-term remission. Sensitivity analysis with an alternative advanced extrapolation technique should be implemented and re-assessment using clinical trial extension data and/or real-world data should be conducted as longer-term data become available." @default.
• W3178611553 created "2021-07-19" @default.
• W3178611553 creator A5025905967 @default.
• W3178611553 creator A5048991618 @default.
• W3178611553 creator A5079320496 @default.
• W3178611553 creator A5087850384 @default.
• W3178611553 date "2021-07-12" @default.
• W3178611553 modified "2023-10-08" @default.
• W3178611553 title "Applying State-of-the-Art Survival Extrapolation Techniques to the Evaluation of CAR-T Therapies: Evidence from a Systematic Literature Review" @default.
• W3178611553 cites W1543389126 @default.
• W3178611553 cites W1995147694 @default.
• W3178611553 cites W1995336896 @default.
• W3178611553 cites W2108174062 @default.
• W3178611553 cites W2115230475 @default.
• W3178611553 cites W2164665019 @default.
• W3178611553 cites W2412666396 @default.
• W3178611553 cites W2751752943 @default.
• W3178611553 cites W2775369717 @default.
• W3178611553 cites W2787301955 @default.
• W3178611553 cites W2890955229 @default.
• W3178611553 cites W2893050608 @default.
• W3178611553 cites W2895644365 @default.
• W3178611553 cites W2900774088 @default.
• W3178611553 cites W2903225254 @default.
• W3178611553 cites W2904448678 @default.
• W3178611553 cites W2904940919 @default.
• W3178611553 cites W2905662036 @default.
• W3178611553 cites W2906002519 @default.
• W3178611553 cites W2906228936 @default.
• W3178611553 cites W2914185992 @default.
• W3178611553 cites W2917035693 @default.
• W3178611553 cites W2920602503 @default.
• W3178611553 cites W2945125147 @default.
• W3178611553 cites W2948047060 @default.
• W3178611553 cites W2948788617 @default.
• W3178611553 cites W2986264979 @default.
• W3178611553 cites W2991246146 @default.
• W3178611553 cites W2996294603 @default.
• W3178611553 cites W2996397438 @default.
• W3178611553 cites W3000418054 @default.
• W3178611553 cites W3002399244 @default.
• W3178611553 cites W3015970146 @default.
• W3178611553 cites W3023982169 @default.
• W3178611553 cites W3024978145 @default.
• W3178611553 cites W3025236648 @default.
• W3178611553 cites W3026470796 @default.
• W3178611553 cites W3095018086 @default.
• W3178611553 cites W3095855647 @default.
• W3178611553 cites W3097169004 @default.
• W3178611553 cites W3097306933 @default.
• W3178611553 cites W3097908464 @default.
• W3178611553 cites W3097912792 @default.
• W3178611553 cites W3112752008 @default.
• W3178611553 cites W3117012558 @default.
• W3178611553 cites W3133229959 @default.
• W3178611553 cites W4294215472 @default.
• W3178611553 doi "https://doi.org/10.1007/s12325-021-01841-4" @default.
• W3178611553 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8342396" @default.
• W3178611553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34251651" @default.
• W3178611553 hasPublicationYear "2021" @default.
• W3178611553 type Work @default.
• W3178611553 sameAs 3178611553 @default.
• W3178611553 citedByCount "4" @default.
• W3178611553 countsByYear W31786115532022 @default.
• W3178611553 countsByYear W31786115532023 @default.
• W3178611553 crossrefType "journal-article" @default.
• W3178611553 hasAuthorship W3178611553A5025905967 @default.
• W3178611553 hasAuthorship W3178611553A5048991618 @default.
• W3178611553 hasAuthorship W3178611553A5079320496 @default.
• W3178611553 hasAuthorship W3178611553A5087850384 @default.
• W3178611553 hasBestOaLocation W31786115531 @default.
• W3178611553 hasConcept C10515644 @default.
• W3178611553 hasConcept C105795698 @default.
• W3178611553 hasConcept C126322002 @default.
• W3178611553 hasConcept C132459708 @default.
• W3178611553 hasConcept C17744445 @default.
• W3178611553 hasConcept C177713679 @default.
• W3178611553 hasConcept C189708586 @default.
• W3178611553 hasConcept C199539241 @default.
• W3178611553 hasConcept C2779473830 @default.
• W3178611553 hasConcept C33923547 @default.
• W3178611553 hasConcept C535046627 @default.
• W3178611553 hasConcept C71924100 @default.
• W3178611553 hasConceptScore W3178611553C10515644 @default.
• W3178611553 hasConceptScore W3178611553C105795698 @default.
• W3178611553 hasConceptScore W3178611553C126322002 @default.
• W3178611553 hasConceptScore W3178611553C132459708 @default.
• W3178611553 hasConceptScore W3178611553C17744445 @default.
• W3178611553 hasConceptScore W3178611553C177713679 @default.
• W3178611553 hasConceptScore W3178611553C189708586 @default.
• W3178611553 hasConceptScore W3178611553C199539241 @default.
• W3178611553 hasConceptScore W3178611553C2779473830 @default.
• W3178611553 hasConceptScore W3178611553C33923547 @default.
• W3178611553 hasConceptScore W3178611553C535046627 @default.
• W3178611553 hasConceptScore W3178611553C71924100 @default.
• W3178611553 hasIssue "8" @default.
• W3178611553 hasLocation W31786115531 @default.
• W3178611553 hasLocation W31786115532 @default.

• next