Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178657505> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3178657505 endingPage "S86" @default.
- W3178657505 startingPage "S77" @default.
- W3178657505 abstract "Asthma is a respiratory disease with a clinically high incidence, and repeated attacks of asthma severely affect the quality of life and even pose a threat to health, leading to severe burdens on families and even the society. A thorough understanding of the pathogenesis of asthma is essential for the prevention and treatment of asthma. This study aimed to examine the effect of the microRNA miR-27a on asthma and its relationship with mitogen activated protein kinase 4 (MAP2K4). Patients with asthma admitted to our hospital from August 2016 to August 2018 and healthy participants in the same period were included in this prospective analysis. The mRNA expression levels of miR-27a and MAP2K4 in peripheral blood were determined. Airway smooth muscle cells (ASMCs) were used to study the effects of miR-27a and MAP2K4 on cell biological behavior. The relationship between miR-27a and MAP2K4 was verified using dual-luciferase reporter assay. miR-27a expression was increased and MAP2K4 mRNA expression was decreased in asthma (P < 0.05). Increasing miR-27a expression and inhibiting MAP2K4 expression could enhance the activity of ASMCs, whereas inhibiting miR-27a expression and increasing MAP2K4 expression had the opposite effect (P < 0.05). Dual-luciferase reporter assay results showed that the fluorescence activity of MAP2K4-wild type was inhibited by increased miR-27a expression (P < 0.05). miR-27a promotes the proliferation and invasion of ASMCs by targeting MAP2K4 and is involved in the occurrence of asthma." @default.
- W3178657505 created "2021-07-19" @default.
- W3178657505 creator A5001882249 @default.
- W3178657505 creator A5017794881 @default.
- W3178657505 creator A5026472765 @default.
- W3178657505 creator A5060744228 @default.
- W3178657505 creator A5061310480 @default.
- W3178657505 creator A5070956313 @default.
- W3178657505 date "2021-07-05" @default.
- W3178657505 modified "2023-09-27" @default.
- W3178657505 title "Role of miR-27a in the regulation of cellular function via the inhibition of MAP2K4 in patients with asthma" @default.
- W3178657505 cites W2022626686 @default.
- W3178657505 cites W2298020141 @default.
- W3178657505 cites W2466390755 @default.
- W3178657505 cites W2539999740 @default.
- W3178657505 cites W2597734728 @default.
- W3178657505 cites W2607287429 @default.
- W3178657505 cites W2608022923 @default.
- W3178657505 cites W2739763856 @default.
- W3178657505 cites W2745366275 @default.
- W3178657505 cites W2757585442 @default.
- W3178657505 cites W2766781744 @default.
- W3178657505 cites W2782355556 @default.
- W3178657505 cites W2793425238 @default.
- W3178657505 cites W2794615847 @default.
- W3178657505 cites W2802816247 @default.
- W3178657505 cites W2804652630 @default.
- W3178657505 cites W2893514746 @default.
- W3178657505 cites W2921032955 @default.
- W3178657505 cites W2955768105 @default.
- W3178657505 cites W2982544200 @default.
- W3178657505 cites W2987858874 @default.
- W3178657505 cites W2996643695 @default.
- W3178657505 cites W2998812916 @default.
- W3178657505 doi "https://doi.org/10.1177/09603271211026738" @default.
- W3178657505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34219538" @default.
- W3178657505 hasPublicationYear "2021" @default.
- W3178657505 type Work @default.
- W3178657505 sameAs 3178657505 @default.
- W3178657505 citedByCount "2" @default.
- W3178657505 countsByYear W31786575052022 @default.
- W3178657505 countsByYear W31786575052023 @default.
- W3178657505 crossrefType "journal-article" @default.
- W3178657505 hasAuthorship W3178657505A5001882249 @default.
- W3178657505 hasAuthorship W3178657505A5017794881 @default.
- W3178657505 hasAuthorship W3178657505A5026472765 @default.
- W3178657505 hasAuthorship W3178657505A5060744228 @default.
- W3178657505 hasAuthorship W3178657505A5061310480 @default.
- W3178657505 hasAuthorship W3178657505A5070956313 @default.
- W3178657505 hasConcept C104317684 @default.
- W3178657505 hasConcept C111335760 @default.
- W3178657505 hasConcept C145059251 @default.
- W3178657505 hasConcept C203014093 @default.
- W3178657505 hasConcept C2776042228 @default.
- W3178657505 hasConcept C2780942790 @default.
- W3178657505 hasConcept C502942594 @default.
- W3178657505 hasConcept C54009773 @default.
- W3178657505 hasConcept C55493867 @default.
- W3178657505 hasConcept C71924100 @default.
- W3178657505 hasConcept C86803240 @default.
- W3178657505 hasConceptScore W3178657505C104317684 @default.
- W3178657505 hasConceptScore W3178657505C111335760 @default.
- W3178657505 hasConceptScore W3178657505C145059251 @default.
- W3178657505 hasConceptScore W3178657505C203014093 @default.
- W3178657505 hasConceptScore W3178657505C2776042228 @default.
- W3178657505 hasConceptScore W3178657505C2780942790 @default.
- W3178657505 hasConceptScore W3178657505C502942594 @default.
- W3178657505 hasConceptScore W3178657505C54009773 @default.
- W3178657505 hasConceptScore W3178657505C55493867 @default.
- W3178657505 hasConceptScore W3178657505C71924100 @default.
- W3178657505 hasConceptScore W3178657505C86803240 @default.
- W3178657505 hasIssue "12_suppl" @default.
- W3178657505 hasLocation W31786575051 @default.
- W3178657505 hasLocation W31786575052 @default.
- W3178657505 hasOpenAccess W3178657505 @default.
- W3178657505 hasPrimaryLocation W31786575051 @default.
- W3178657505 hasRelatedWork W2375180626 @default.
- W3178657505 hasRelatedWork W2385418199 @default.
- W3178657505 hasRelatedWork W2389675558 @default.
- W3178657505 hasRelatedWork W2393579621 @default.
- W3178657505 hasRelatedWork W2610754348 @default.
- W3178657505 hasRelatedWork W3029027390 @default.
- W3178657505 hasRelatedWork W3029557531 @default.
- W3178657505 hasRelatedWork W3031117793 @default.
- W3178657505 hasRelatedWork W3032335331 @default.
- W3178657505 hasRelatedWork W4322724676 @default.
- W3178657505 hasVolume "40" @default.
- W3178657505 isParatext "false" @default.
- W3178657505 isRetracted "true" @default.
- W3178657505 magId "3178657505" @default.
- W3178657505 workType "article" @default.