Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178661607> ?p ?o ?g. }
- W3178661607 endingPage "113504" @default.
- W3178661607 startingPage "113504" @default.
- W3178661607 abstract "Although urinary exosomal microRNAs (miRNAs) have recently emerged as potential biomarkers, clinical applications are still limited due to their low concentration in small volumes of clinical samples. Therefore, the development of a non-invasive, specific diagnostic tool, along with profiling exosomal miRNA markers from urine, remains a significant challenge. Here, we present hydrogel-based hybridization chain reaction (HCR) for multiplex signal amplification to detect urinary exosomal miRNAs from human clinical samples. We succeeded in identifying small amounts (~amol) of exosomal miRNAs from 600 μL of urine with up to ~35-fold amplification and enhanced detection limits by over an order of magnitude for two miRNA biomarker candidates, hsa-miR-6090 and hsa-miR-3665. Furthermore, we proposed ratiometric analysis without requiring normalization to a reference miRNA and validated the clinical diagnostic potential toward differentiating prostate cancer patients from healthy controls. Our hydrogel-based HCR could serve as a new diagnostic platform for a non-invasive liquid biopsy before burdensome tissue biopsy of various diseases, including prostate cancer screening, complementing the PSA test." @default.
- W3178661607 created "2021-07-19" @default.
- W3178661607 creator A5001822994 @default.
- W3178661607 creator A5023794052 @default.
- W3178661607 creator A5035452946 @default.
- W3178661607 creator A5040500630 @default.
- W3178661607 creator A5058246995 @default.
- W3178661607 creator A5065101557 @default.
- W3178661607 creator A5065836913 @default.
- W3178661607 creator A5074072406 @default.
- W3178661607 creator A5076224024 @default.
- W3178661607 creator A5086063389 @default.
- W3178661607 date "2021-11-01" @default.
- W3178661607 modified "2023-10-13" @default.
- W3178661607 title "Hydrogel-based hybridization chain reaction (HCR) for detection of urinary exosomal miRNAs as a diagnostic tool of prostate cancer" @default.
- W3178661607 cites W1818377109 @default.
- W3178661607 cites W1963691340 @default.
- W3178661607 cites W1973459440 @default.
- W3178661607 cites W1973866004 @default.
- W3178661607 cites W1978268874 @default.
- W3178661607 cites W1981777743 @default.
- W3178661607 cites W1984164149 @default.
- W3178661607 cites W1990147609 @default.
- W3178661607 cites W2008662133 @default.
- W3178661607 cites W2009754850 @default.
- W3178661607 cites W2022667041 @default.
- W3178661607 cites W2027571016 @default.
- W3178661607 cites W2030897137 @default.
- W3178661607 cites W2044949573 @default.
- W3178661607 cites W2046758915 @default.
- W3178661607 cites W2055313665 @default.
- W3178661607 cites W2066649475 @default.
- W3178661607 cites W2068717924 @default.
- W3178661607 cites W2086275775 @default.
- W3178661607 cites W2088170018 @default.
- W3178661607 cites W2089135124 @default.
- W3178661607 cites W2099142844 @default.
- W3178661607 cites W2102946765 @default.
- W3178661607 cites W2106045450 @default.
- W3178661607 cites W2128513083 @default.
- W3178661607 cites W2148304424 @default.
- W3178661607 cites W2148987313 @default.
- W3178661607 cites W2151922790 @default.
- W3178661607 cites W2152171769 @default.
- W3178661607 cites W2157968886 @default.
- W3178661607 cites W2158474917 @default.
- W3178661607 cites W2161661776 @default.
- W3178661607 cites W2162578061 @default.
- W3178661607 cites W2167977613 @default.
- W3178661607 cites W2235442421 @default.
- W3178661607 cites W2271213700 @default.
- W3178661607 cites W2301491789 @default.
- W3178661607 cites W2320229303 @default.
- W3178661607 cites W2405245138 @default.
- W3178661607 cites W2412782622 @default.
- W3178661607 cites W2566807314 @default.
- W3178661607 cites W2610129401 @default.
- W3178661607 cites W2625836171 @default.
- W3178661607 cites W2752866458 @default.
- W3178661607 cites W2765084328 @default.
- W3178661607 cites W2765212981 @default.
- W3178661607 cites W2794463786 @default.
- W3178661607 cites W2808487976 @default.
- W3178661607 cites W2884021658 @default.
- W3178661607 cites W2908555215 @default.
- W3178661607 cites W2944114961 @default.
- W3178661607 cites W2991066109 @default.
- W3178661607 cites W3000919623 @default.
- W3178661607 cites W3003125013 @default.
- W3178661607 cites W3012680772 @default.
- W3178661607 cites W3019099939 @default.
- W3178661607 cites W3036189845 @default.
- W3178661607 cites W3083491394 @default.
- W3178661607 cites W4248873606 @default.
- W3178661607 doi "https://doi.org/10.1016/j.bios.2021.113504" @default.
- W3178661607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34298498" @default.
- W3178661607 hasPublicationYear "2021" @default.
- W3178661607 type Work @default.
- W3178661607 sameAs 3178661607 @default.
- W3178661607 citedByCount "39" @default.
- W3178661607 countsByYear W31786616072021 @default.
- W3178661607 countsByYear W31786616072022 @default.
- W3178661607 countsByYear W31786616072023 @default.
- W3178661607 crossrefType "journal-article" @default.
- W3178661607 hasAuthorship W3178661607A5001822994 @default.
- W3178661607 hasAuthorship W3178661607A5023794052 @default.
- W3178661607 hasAuthorship W3178661607A5035452946 @default.
- W3178661607 hasAuthorship W3178661607A5040500630 @default.
- W3178661607 hasAuthorship W3178661607A5058246995 @default.
- W3178661607 hasAuthorship W3178661607A5065101557 @default.
- W3178661607 hasAuthorship W3178661607A5065836913 @default.
- W3178661607 hasAuthorship W3178661607A5074072406 @default.
- W3178661607 hasAuthorship W3178661607A5076224024 @default.
- W3178661607 hasAuthorship W3178661607A5086063389 @default.
- W3178661607 hasBestOaLocation W31786616071 @default.
- W3178661607 hasConcept C104317684 @default.
- W3178661607 hasConcept C121608353 @default.
- W3178661607 hasConcept C126322002 @default.