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- W3178665220 abstract "Materials. 137 patients were divided into two clinical groups: the first (main) group consisted of 103 patientswith male infertility due to EDO, and the second (control) group included 34 practically healthy men.Results. The study of globulin concentration binding sex hormones showed its increase in men of themain group within 26.7 ± 12.5 %, compared with the control group 27.1 ± 9.2 nmol/l versus 21.3 ± 3.9 nmol/l,respectively (p = 0.406483). The mean indicator of androgen index in patients with EDO was at the lower limitsof the norm and made up 70 %, amounting to 84.3 ± 19.8 % compared with 110.8 ± 11.5 % in the control group(p = 0.085391). The average concentration of gonadotropins was slightly higher in the patients with EDO comparedwith practically healthy men, but within the statistical error. The corresponding values of FSH and LHwere 4.1 ± 2.1 and 5.1 ± 3.9 mIU/ml versus 3.5 ± 1.8 and 4.4 ± 1.7 mIU/ml in the control group (p > 0.05). Therewere no differences in the content of BPD which was 239.5 ± 82.6 versus 234.2 ± 75.7 mIU/ml, (p > 0.05).Conclusions. 22.3 % of patients with EDO had a hidden or relative androgen deficiency, characterized by70 % decrease in AI at the corresponding normal levels of total T on the background of increasing SHBG concentration,influenced by the age changes (older than 40 years, χ2 = 34.05; p < 0.001), previously cured orchid orepididymitis (χ2 = 5.06; p < 0.025), and additional marker of unrealized reproductive function (lack of pregnancyin sexual partners: χ2 = 7.96; p < 0.005). There was no reliable relationship between relative androgen deficiencyand the incidence of prostatitis in anamnesis (χ2 = 2.99; p > 0.05). The fact of previously cured prostatitis didnot affect the frequency of AI reduction in patients with EDO. The highlighted peculiarities of the hormonalprofile in patients with EDO confirmed the secondary (acquired) nature of the genesis of ejaculatory duct obstruction.They also showed that this pathology had a tendency to gradually suppress the function of the testesand form androgen deficiency proved by lower AI." @default.
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- W3178665220 date "2020-05-20" @default.
- W3178665220 modified "2023-09-24" @default.
- W3178665220 title "PECULIARITIES OF HORMONAL REGULATION OF REPRODUCTIVE FUNCTION IN PATIENTS WITH EJACULATORY DUCT OBSTRUCTION" @default.
- W3178665220 doi "https://doi.org/10.21856/j-pep.2020.2.08" @default.
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