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- W3178669904 abstract "The epithelial-mesenchymal transition (EMT) has been implicated in conferring stem cell properties and therapeutic resistance to cancer cells. Therefore, identification of drugs that can reprogram EMT may provide new therapeutic strategies. Here, we report that cells derived from claudin-low mammary tumors, a mesenchymal subtype of triple-negative breast cancer, exhibit a distinctive organoid structure with extended spikes in 3D matrices. Upon a miR-200 induced mesenchymal-epithelial transition (MET), the organoids switch to a smoother round morphology. Based on these observations, we developed a morphological screening method with accompanying analytical pipelines that leverage deep neural networks and nearest neighborhood classification to screen for EMT-reversing drugs. Through screening of a targeted epigenetic drug library, we identified multiple class I HDAC inhibitors and Bromodomain inhibitors that reverse EMT. These data support the use of morphological screening of mesenchymal mammary tumor organoids as a platform to identify drugs that reverse EMT." @default.
- W3178669904 created "2021-07-19" @default.
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- W3178669904 date "2021-07-12" @default.
- W3178669904 modified "2023-09-29" @default.
- W3178669904 title "Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition" @default.
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- W3178669904 doi "https://doi.org/10.1038/s41467-021-24545-3" @default.
- W3178669904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8275587" @default.
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- W3178669904 hasPublicationYear "2021" @default.
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