FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178699661> ?p ?o ?g. }

• W3178699661 abstract "Multiplex immunofluorescence and immunohistochemistry benefit patients by allowing cancer pathologists to identify several proteins expressed on the surface of cells, enabling cell classification, better understanding of the tumour micro-environment, more accurate diagnoses, prognoses, and tailored immunotherapy based on the immune status of individual patients. However, they are expensive and time consuming processes which require complex staining and imaging techniques by expert technicians. Hoechst staining is much cheaper and easier to perform, but is not typically used in this case as it binds to DNA rather than to the proteins targeted by immunofluorescent techniques, and it was not previously thought possible to differentiate cells expressing these proteins based only on DNA morphology. In this work we show otherwise, training a deep convolutional neural network to identify cells expressing three proteins (T lymphocyte markers CD3 and CD8, and the B lymphocyte marker CD20) with greater than 90% precision and recall, from Hoechst 33342 stained tissue only. Our model learns previously unknown morphological features associated with expression of these proteins which can be used to accurately differentiate lymphocyte subtypes for use in key prognostic metrics such as assessment of immune cell infiltration,and thereby predict and improve patient outcomes without the need for costly multiplex immunofluorescence." @default.
• W3178699661 created "2021-07-19" @default.
• W3178699661 creator A5010468035 @default.
• W3178699661 creator A5020799762 @default.
• W3178699661 creator A5064922783 @default.
• W3178699661 creator A5089680252 @default.
• W3178699661 date "2021-07-09" @default.
• W3178699661 modified "2023-09-24" @default.
• W3178699661 title "Hoechst Is All You Need: Lymphocyte Classification with Deep Learning." @default.
• W3178699661 cites W1859257957 @default.
• W3178699661 cites W1901129140 @default.
• W3178699661 cites W2025623420 @default.
• W3178699661 cites W2095596891 @default.
• W3178699661 cites W2114223486 @default.
• W3178699661 cites W2124568178 @default.
• W3178699661 cites W2188544535 @default.
• W3178699661 cites W2194775991 @default.
• W3178699661 cites W2582220857 @default.
• W3178699661 cites W2726102591 @default.
• W3178699661 cites W2748065364 @default.
• W3178699661 cites W2763518120 @default.
• W3178699661 cites W2788906943 @default.
• W3178699661 cites W2884561390 @default.
• W3178699661 cites W2889822862 @default.
• W3178699661 cites W2904068706 @default.
• W3178699661 cites W2950541952 @default.
• W3178699661 cites W2952481429 @default.
• W3178699661 cites W2953537196 @default.
• W3178699661 cites W2956013636 @default.
• W3178699661 cites W2962851944 @default.
• W3178699661 cites W2998784361 @default.
• W3178699661 cites W3009048917 @default.
• W3178699661 cites W3017374234 @default.
• W3178699661 cites W3047106569 @default.
• W3178699661 cites W3080621690 @default.
• W3178699661 cites W3094071141 @default.
• W3178699661 cites W3096502673 @default.
• W3178699661 cites W3135849159 @default.
• W3178699661 cites W3154478400 @default.
• W3178699661 hasPublicationYear "2021" @default.
• W3178699661 type Work @default.
• W3178699661 sameAs 3178699661 @default.
• W3178699661 citedByCount "0" @default.
• W3178699661 crossrefType "posted-content" @default.
• W3178699661 hasAuthorship W3178699661A5010468035 @default.
• W3178699661 hasAuthorship W3178699661A5020799762 @default.
• W3178699661 hasAuthorship W3178699661A5064922783 @default.
• W3178699661 hasAuthorship W3178699661A5089680252 @default.
• W3178699661 hasConcept C114684123 @default.
• W3178699661 hasConcept C142724271 @default.
• W3178699661 hasConcept C154945302 @default.
• W3178699661 hasConcept C159654299 @default.
• W3178699661 hasConcept C167672396 @default.
• W3178699661 hasConcept C18031839 @default.
• W3178699661 hasConcept C203014093 @default.
• W3178699661 hasConcept C204232928 @default.
• W3178699661 hasConcept C2777761686 @default.
• W3178699661 hasConcept C2778236600 @default.
• W3178699661 hasConcept C2781188995 @default.
• W3178699661 hasConcept C41008148 @default.
• W3178699661 hasConcept C60644358 @default.
• W3178699661 hasConcept C70721500 @default.
• W3178699661 hasConcept C71924100 @default.
• W3178699661 hasConcept C81363708 @default.
• W3178699661 hasConcept C86803240 @default.
• W3178699661 hasConcept C8891405 @default.
• W3178699661 hasConceptScore W3178699661C114684123 @default.
• W3178699661 hasConceptScore W3178699661C142724271 @default.
• W3178699661 hasConceptScore W3178699661C154945302 @default.
• W3178699661 hasConceptScore W3178699661C159654299 @default.
• W3178699661 hasConceptScore W3178699661C167672396 @default.
• W3178699661 hasConceptScore W3178699661C18031839 @default.
• W3178699661 hasConceptScore W3178699661C203014093 @default.
• W3178699661 hasConceptScore W3178699661C204232928 @default.
• W3178699661 hasConceptScore W3178699661C2777761686 @default.
• W3178699661 hasConceptScore W3178699661C2778236600 @default.
• W3178699661 hasConceptScore W3178699661C2781188995 @default.
• W3178699661 hasConceptScore W3178699661C41008148 @default.
• W3178699661 hasConceptScore W3178699661C60644358 @default.
• W3178699661 hasConceptScore W3178699661C70721500 @default.
• W3178699661 hasConceptScore W3178699661C71924100 @default.
• W3178699661 hasConceptScore W3178699661C81363708 @default.
• W3178699661 hasConceptScore W3178699661C86803240 @default.
• W3178699661 hasConceptScore W3178699661C8891405 @default.
• W3178699661 hasLocation W31786996611 @default.
• W3178699661 hasOpenAccess W3178699661 @default.
• W3178699661 hasPrimaryLocation W31786996611 @default.
• W3178699661 hasRelatedWork W1502967937 @default.
• W3178699661 hasRelatedWork W162222808 @default.
• W3178699661 hasRelatedWork W2008540682 @default.
• W3178699661 hasRelatedWork W2055277628 @default.
• W3178699661 hasRelatedWork W2179163778 @default.
• W3178699661 hasRelatedWork W2246273373 @default.
• W3178699661 hasRelatedWork W2399898648 @default.
• W3178699661 hasRelatedWork W2693106745 @default.
• W3178699661 hasRelatedWork W2741282004 @default.
• W3178699661 hasRelatedWork W2805271503 @default.
• W3178699661 hasRelatedWork W2885477562 @default.
• W3178699661 hasRelatedWork W2946780835 @default.
• W3178699661 hasRelatedWork W2973177036 @default.

• next