Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178706217> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W3178706217 endingPage "115" @default.
- W3178706217 startingPage "111" @default.
- W3178706217 abstract "Abstract Background Brainstem lesions are a diagnostic challenge and clinicians have to differentiate between many diseases including acute disseminated encephalomyelitis, multiple sclerosis (MS), Bickerstaff brainstem encephalitis (BBE) and brain tumors. The anti‐galactocerebroside (Gal‐C) antibody is an anti‐glycolipid antibody that is often detected in autoimmune peripheral neuropathy. However, anti‐Gal‐C antibody is rarely detected in autoimmune central nervous system diseases. Here, we report the case of an anti‐Gal‐C antibody‐positive patient who had a brainstem lesion that mimicked MS and responded to immunotherapy. Case presentation We report a 32‐year‐old woman who presented with subacute numbness of the right lower extremities and hemiataxia. Her cerebrospinal fluid examination showed an elevated myelin basic protein level and an oligoclonal band. Brain magnetic resonance imaging showed a T2 high‐intensity lesion from the left brainstem to the cerebellum. She was treated with steroid pulse therapy, but internuclear ophthalmoplegia and left peripheral facial palsy developed. Her brain magnetic resonance imaging showed an enlargement of the brainstem lesion. Therefore, plasma exchange therapy and high‐dose immunoglobulin therapy were administered, and her symptoms eventually ameliorated. First, we diagnosed her with MS and started dimethyl fumarate. After anti‐GM2 and anti‐Gal‐C antibody positivity was revealed, we diagnosed an anti‐Gal‐C antibody‐related brainstem lesion. There have been few reports of anti‐Gal‐C antibody‐positive central nervous system diseases. Conclusions The present case highlights that an anti‐Gal‐C positivity can cause brainstem inflammatory lesions, which should be differentiated from acute disseminated encephalomyelitis, Bickerstaff brainstem encephalitis and MS. The patient’s symptoms improved with intense immunotherapy, and antibody measurement led to the discontinuation of unnecessary disease‐modifying drugs." @default.
- W3178706217 created "2021-07-19" @default.
- W3178706217 creator A5085309171 @default.
- W3178706217 date "2021-07-23" @default.
- W3178706217 modified "2023-10-16" @default.
- W3178706217 title "Immunotherapy‐responsive brainstem lesion accompanied with anti‐galactocerebroside antibody" @default.
- W3178706217 cites W1823312016 @default.
- W3178706217 cites W1994049366 @default.
- W3178706217 cites W1995408163 @default.
- W3178706217 cites W2022584593 @default.
- W3178706217 cites W2025358672 @default.
- W3178706217 cites W2074799982 @default.
- W3178706217 cites W2082931808 @default.
- W3178706217 cites W2106923558 @default.
- W3178706217 cites W2116399045 @default.
- W3178706217 cites W2119104943 @default.
- W3178706217 cites W2122545833 @default.
- W3178706217 cites W2188050305 @default.
- W3178706217 cites W2561228923 @default.
- W3178706217 cites W2777074421 @default.
- W3178706217 cites W2970730051 @default.
- W3178706217 cites W3116623489 @default.
- W3178706217 doi "https://doi.org/10.1111/cen3.12660" @default.
- W3178706217 hasPublicationYear "2021" @default.
- W3178706217 type Work @default.
- W3178706217 sameAs 3178706217 @default.
- W3178706217 citedByCount "1" @default.
- W3178706217 countsByYear W31787062172023 @default.
- W3178706217 crossrefType "journal-article" @default.
- W3178706217 hasAuthorship W3178706217A5085309171 @default.
- W3178706217 hasConcept C126322002 @default.
- W3178706217 hasConcept C142724271 @default.
- W3178706217 hasConcept C203014093 @default.
- W3178706217 hasConcept C2776985911 @default.
- W3178706217 hasConcept C2777899865 @default.
- W3178706217 hasConcept C2778609137 @default.
- W3178706217 hasConcept C2779328510 @default.
- W3178706217 hasConcept C2780640218 @default.
- W3178706217 hasConcept C2781017270 @default.
- W3178706217 hasConcept C2781156865 @default.
- W3178706217 hasConcept C529278444 @default.
- W3178706217 hasConcept C551621295 @default.
- W3178706217 hasConcept C71924100 @default.
- W3178706217 hasConceptScore W3178706217C126322002 @default.
- W3178706217 hasConceptScore W3178706217C142724271 @default.
- W3178706217 hasConceptScore W3178706217C203014093 @default.
- W3178706217 hasConceptScore W3178706217C2776985911 @default.
- W3178706217 hasConceptScore W3178706217C2777899865 @default.
- W3178706217 hasConceptScore W3178706217C2778609137 @default.
- W3178706217 hasConceptScore W3178706217C2779328510 @default.
- W3178706217 hasConceptScore W3178706217C2780640218 @default.
- W3178706217 hasConceptScore W3178706217C2781017270 @default.
- W3178706217 hasConceptScore W3178706217C2781156865 @default.
- W3178706217 hasConceptScore W3178706217C529278444 @default.
- W3178706217 hasConceptScore W3178706217C551621295 @default.
- W3178706217 hasConceptScore W3178706217C71924100 @default.
- W3178706217 hasIssue "2" @default.
- W3178706217 hasLocation W31787062171 @default.
- W3178706217 hasOpenAccess W3178706217 @default.
- W3178706217 hasPrimaryLocation W31787062171 @default.
- W3178706217 hasRelatedWork W1969546473 @default.
- W3178706217 hasRelatedWork W2016431156 @default.
- W3178706217 hasRelatedWork W2017885089 @default.
- W3178706217 hasRelatedWork W2019932697 @default.
- W3178706217 hasRelatedWork W2056513505 @default.
- W3178706217 hasRelatedWork W2322830492 @default.
- W3178706217 hasRelatedWork W2413149478 @default.
- W3178706217 hasRelatedWork W2738158006 @default.
- W3178706217 hasRelatedWork W3179833405 @default.
- W3178706217 hasRelatedWork W4243485935 @default.
- W3178706217 hasVolume "13" @default.
- W3178706217 isParatext "false" @default.
- W3178706217 isRetracted "false" @default.
- W3178706217 magId "3178706217" @default.
- W3178706217 workType "article" @default.