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- W3178748031 abstract "Background: Cytochrome P450 2C19 (CYP2C19) play a versatile role in the metabolism of drugs. CYP2C19*17 variant allele increases the metabolic activity of the CYP2C19 resulting in ultra-rapid metabolizers phenotype in the individuals and decreases the therapeutic levels of substrate. Studies show that there are inter-ethnic differences in allele distribution.Methods: We recruited 48 IHD patients, demographic and biochemical parameters collected and genotype for CYP2C19*17 were studied using nested PCR-restriction fragment length polymorphism (PCR-RFLP) method. Statistical analyses were carried out using SPSS software.Results: The total allelic frequency of CYP2C19*17 was found to be 20% in our study population. Among the study subjects, 4.2% were homozygous mutant, 33.3% heterozygous and 62.5% homozygous wild genotype.Conclusion: The frequency of CYP2C19*17 is less compared to other studies. This may be due to the small sample size and inter-ethnic differences. So further elaborate study is essential to evaluate the genotype-phenotype association and clinical utility of this variant." @default.
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- W3178748031 date "2021-01-01" @default.
- W3178748031 modified "2023-09-24" @default.
- W3178748031 title "CYP2C19*17 gene polymorphismA pilot study" @default.
- W3178748031 hasPublicationYear "2021" @default.
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