FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178762669> ?p ?o ?g. }

• W3178762669 endingPage "411" @default.
• W3178762669 startingPage "402" @default.
• W3178762669 abstract "Tegoprazan is a novel, fast- and long-acting potassium-competitive acid blocker that suppresses gastric acid secretion, which could benefit patients with non-erosive reflux disease (NERD), a type of gastroesophageal reflux disease.To evaluate the efficacy and safety profiles of tegoprazan compared with those of a placebo in Korean patients with NERD.In this phase 3, double-blind, placebo-controlled, multicentre study, 324 Korean patients with NERD were randomised into three treatment groups: tegoprazan 50 mg, tegoprazan 100 mg and placebo. These drugs were provided once daily for 4 weeks. The primary endpoint was the proportion of patients with complete resolution of major symptoms (both heartburn and regurgitation) for the last 7 days of the 4-week treatment period. Other outcomes related to efficacy, safety and tolerability were also evaluated.Among all, 42.5% (45/106), 48.5% (48/99) and 24.2% (24/99) of patients showed complete resolution of major symptoms at week 4 after receiving tegoprazan 50 mg, tegoprazan 100 mg, and placebo, respectively. Both doses of tegoprazan showed superior efficacy than the placebo (P = 0.0058 and P = 0.0004, respectively). The complete resolution rates of heartburn and proportions of heartburn-free days (as other efficacy outcomes) were significantly higher in both tegoprazan groups than in the placebo group (P < 0.05 for all). No significant difference in the incidence of treatment-emergent adverse events were noted.Tegoprazan 50 and 100 mg showed superior therapeutic efficacy compared with the placebo, as well as a favourable safety profile in patients with NERD. Registration number: ClinicalTrials.gov identifier NCT02556021." @default.
• W3178762669 created "2021-07-19" @default.
• W3178762669 creator A5002996109 @default.
• W3178762669 creator A5008663578 @default.
• W3178762669 creator A5009735986 @default.
• W3178762669 creator A5011861620 @default.
• W3178762669 creator A5019652970 @default.
• W3178762669 creator A5024491216 @default.
• W3178762669 creator A5026541726 @default.
• W3178762669 creator A5026612909 @default.
• W3178762669 creator A5031993607 @default.
• W3178762669 creator A5034230408 @default.
• W3178762669 creator A5044933579 @default.
• W3178762669 creator A5050943079 @default.
• W3178762669 creator A5050946440 @default.
• W3178762669 creator A5051127536 @default.
• W3178762669 creator A5061249927 @default.
• W3178762669 creator A5064968952 @default.
• W3178762669 creator A5072860238 @default.
• W3178762669 creator A5073284312 @default.
• W3178762669 creator A5075088268 @default.
• W3178762669 creator A5077038657 @default.
• W3178762669 creator A5082320712 @default.
• W3178762669 creator A5085725295 @default.
• W3178762669 creator A5086788596 @default.
• W3178762669 date "2021-07-06" @default.
• W3178762669 modified "2023-10-17" @default.
• W3178762669 title "Randomised clinical trial: comparison of tegoprazan and placebo in non‐erosive reflux disease" @default.
• W3178762669 cites W1563771419 @default.
• W3178762669 cites W1597918229 @default.
• W3178762669 cites W1837165550 @default.
• W3178762669 cites W1976272657 @default.
• W3178762669 cites W1979773953 @default.
• W3178762669 cites W1986546366 @default.
• W3178762669 cites W1997581609 @default.
• W3178762669 cites W2000702096 @default.
• W3178762669 cites W2008373894 @default.
• W3178762669 cites W2025841048 @default.
• W3178762669 cites W2040797602 @default.
• W3178762669 cites W2053253142 @default.
• W3178762669 cites W2071521423 @default.
• W3178762669 cites W2082193474 @default.
• W3178762669 cites W2106435520 @default.
• W3178762669 cites W2114442699 @default.
• W3178762669 cites W2129558138 @default.
• W3178762669 cites W2130563661 @default.
• W3178762669 cites W2135287136 @default.
• W3178762669 cites W2154293008 @default.
• W3178762669 cites W2158690779 @default.
• W3178762669 cites W2168191670 @default.
• W3178762669 cites W2172306046 @default.
• W3178762669 cites W2478852966 @default.
• W3178762669 cites W2563981115 @default.
• W3178762669 cites W2738903383 @default.
• W3178762669 cites W2770509131 @default.
• W3178762669 cites W2794663694 @default.
• W3178762669 cites W2801245286 @default.
• W3178762669 cites W2903000462 @default.
• W3178762669 cites W2922114939 @default.
• W3178762669 cites W2969713145 @default.
• W3178762669 cites W2987027580 @default.
• W3178762669 cites W3012008607 @default.
• W3178762669 cites W3043995542 @default.
• W3178762669 cites W3096140162 @default.
• W3178762669 cites W3178762669 @default.
• W3178762669 doi "https://doi.org/10.1111/apt.16477" @default.
• W3178762669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8361733" @default.
• W3178762669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34227708" @default.
• W3178762669 hasPublicationYear "2021" @default.
• W3178762669 type Work @default.
• W3178762669 sameAs 3178762669 @default.
• W3178762669 citedByCount "19" @default.
• W3178762669 countsByYear W31787626692021 @default.
• W3178762669 countsByYear W31787626692022 @default.
• W3178762669 countsByYear W31787626692023 @default.
• W3178762669 crossrefType "journal-article" @default.
• W3178762669 hasAuthorship W3178762669A5002996109 @default.
• W3178762669 hasAuthorship W3178762669A5008663578 @default.
• W3178762669 hasAuthorship W3178762669A5009735986 @default.
• W3178762669 hasAuthorship W3178762669A5011861620 @default.
• W3178762669 hasAuthorship W3178762669A5019652970 @default.
• W3178762669 hasAuthorship W3178762669A5024491216 @default.
• W3178762669 hasAuthorship W3178762669A5026541726 @default.
• W3178762669 hasAuthorship W3178762669A5026612909 @default.
• W3178762669 hasAuthorship W3178762669A5031993607 @default.
• W3178762669 hasAuthorship W3178762669A5034230408 @default.
• W3178762669 hasAuthorship W3178762669A5044933579 @default.
• W3178762669 hasAuthorship W3178762669A5050943079 @default.
• W3178762669 hasAuthorship W3178762669A5050946440 @default.
• W3178762669 hasAuthorship W3178762669A5051127536 @default.
• W3178762669 hasAuthorship W3178762669A5061249927 @default.
• W3178762669 hasAuthorship W3178762669A5064968952 @default.
• W3178762669 hasAuthorship W3178762669A5072860238 @default.
• W3178762669 hasAuthorship W3178762669A5073284312 @default.
• W3178762669 hasAuthorship W3178762669A5075088268 @default.
• W3178762669 hasAuthorship W3178762669A5077038657 @default.
• W3178762669 hasAuthorship W3178762669A5082320712 @default.
• W3178762669 hasAuthorship W3178762669A5085725295 @default.

• next