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- W3178837595 abstract "Abstract Bone marrow development and endochondral bone formation occur simultaneously. During endochondral ossification, periosteal vasculatures and stromal progenitors invade the primary avascular cartilaginous anlage; this induces primitive marrow development. We previously determined that bone marrow podoplanin (PDPN)-expressing stromal cells exist in a perivascular microenvironment, and promote megakaryopoiesis and erythropoiesis. In this study, we aimed to examine the involvement of PDPN-expressing stromal cells in the postnatal bone marrow generation. We found that periosteum-derived PDPN-expressing stromal cells regulate vascularization during postnatal epiphyseal marrow development. Our findings suggest that these cells act as pericytes on the primitive vasculature of the nascent marrow. They invade the cartilaginous epiphysis and regulate marrow development and homeostasis by maintaining vascular integrity. To the best of our knowledge, this is the first study to comprehensively examine how PDPN-expressing stromal cells contribute to marrow development and homeostasis." @default.
- W3178837595 created "2021-07-19" @default.
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- W3178837595 date "2021-07-05" @default.
- W3178837595 modified "2023-10-14" @default.
- W3178837595 title "Periosteum-derived podoplanin-expressing stromal cells regulate nascent vascularization during epiphyseal marrow development" @default.
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- W3178837595 doi "https://doi.org/10.1101/2021.07.05.451096" @default.
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