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• W3178932019 abstract "Objective To observe the therapeutic effect of swertiamarin on diabetic peripheral neuropathy (DPN) in rats and explore the molecular mechanism in light of the NOXS/ROS/NLRP3 signal pathway. Objective Thirty-two SD rats were randomly divided into control group, DPN model group (treated with saline), swertiamarin (5 mg/kg) treatment group and NOXS inhibitor (10 mL/kg DPI) treatment group. Rat models of DPN were established in the latter 3 groups by intraperitoneal injections of STZ, and the treatments were administered on days 1, 7 and 14 after modeling. Tactile hypersensitivity of the rats was evaluated 30 min after the treatment. The expressions of NOXS, ROS, NLRP3 and inflammatory factors in the spinal cord tissue were detected using ELISA, and the protein expressions of NOXS, ROS, and NLRP3 were also detected with Western blotting. Objective Compared with those in the control group, the rats in DPN group showed significant hyperalgesia (P 0.05). Objective DPN effectively relieves hyperalgesia in rat models of DPN by restoring the balance in the expressions of the inflammatory factors by suppressing NOXs/ROS/NLRP3 signaling pathway." @default.
• W3178932019 created "2021-07-19" @default.
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• W3178932019 date "2021-06-20" @default.
• W3178932019 modified "2023-09-26" @default.
• W3178932019 title "[Swertiamarin alleviates diabetic peripheral neuropathy in rats by suppressing NOXS/ ROS/NLRP3 signal pathway]." @default.
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• W3178932019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8267977" @default.
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