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• W3178994031 abstract "Pleural in adults has considerable morbidity and continues to be a life-threatening condition. The term infection encompasses complicated parapneumonic effusions and primary pleural infections, and includes but is not limited to empyema, which refers to collection of pus in the pleural cavity. The incidence of pleural in adults has been continuously increasing over the past two decades, particularly in older adults, and most of such patients have comorbidities. Management of pleural requires prolonged duration of hospitalization (average 14 days). There are recognized differences in microbial etiology of pleural depending on whether the was acquired in the community or in a health-care setting. Anaerobic bacteria are acknowledged as a major cause of pleural infection, and thus anaerobic coverage in antibiotic regimens for pleural is mandatory. The key components of managing pleural are appropriate antimicrobial therapy and chest-tube drainage. In patients who fail medical therapy by manifesting persistent sepsis despite standard measures, surgical intervention to clear the infected space or intrapleural fibrinolytic therapy (in poor surgical candidates) are recommended. Recent studies have explored the role of early intrapleural fibrinolytics or first-line surgery, but due to considerable costs of such interventions and the lack of convincing evidence of improved outcomes with early use, early intervention cannot be recommended, and further evidence is awaited from ongoing studies. Other areas of research include the role of routine molecular testing of infected pleural fluid in improving the rate of identification of causative organisms. Other research topics include the benefit of such interventions as medical thoracoscopy, high-volume pleural irrigation with saline/antiseptic solution, and repeated thoracentesis (as opposed to chest-tube drainage) in reducing morbidity and improving outcomes of pleural infection. This review summarizes current knowledge and practice in managing pleural and future research directions." @default.
• W3178994031 created "2021-07-19" @default.
• W3178994031 creator A5018163719 @default.
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• W3178994031 date "2021-07-01" @default.
• W3178994031 modified "2023-10-01" @default.
• W3178994031 title "Recent Insights into the Management of Pleural Infection" @default.
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