FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3179036350> ?p ?o ?g. }

• W3179036350 endingPage "1050" @default.
• W3179036350 startingPage "1050" @default.
• W3179036350 abstract "Hereditary breast and ovarian cancer is caused by a germline mutation in BRCA1 or BRCA2 genes. The frequency of germline BRCA1/2 gene mutation carriers and the ratio of germline BRCA1 to BRCA2 mutations in BRCA-related cancer patients vary depending on the population. Genotype and phenotype correlations have been reported in BRCA mutant families, however, the correlations are rarely used for individual risk assessment and management. BRCA genetic testing has become a companion diagnostic for PARP inhibitors, and the number of families with germline BRCA mutation identified is growing rapidly. Therefore, it is expected that analysis of the risk of developing cancer will be possible in a large number of BRCA mutant carriers, and there is a possibility that personal and precision medicine for the carriers with specific common founder mutations will be realized. In this review, we investigated the association of ovarian cancer risk and BRCA mutation location, and differences of other BRCA-related cancer risks by BRCA1/2 mutation, and furthermore, we discussed the difference in the prevalence of germline BRCA mutation in ovarian cancer patients. As a result, although there are various discussions, there appear to be differences in ovarian cancer risk by population and BRCA mutation location. If it becomes possible to estimate the risk of developing BRCA-related cancer for each BRCA mutation type, the age at risk-reducing salpingo-oophorectomy can be determined individually. The decision would bring great benefits to young women with germline BRCA mutations." @default.
• W3179036350 created "2021-07-19" @default.
• W3179036350 creator A5008885403 @default.
• W3179036350 creator A5032960175 @default.
• W3179036350 creator A5056238856 @default.
• W3179036350 date "2021-07-08" @default.
• W3179036350 modified "2023-09-27" @default.
• W3179036350 title "Differences in Ovarian and Other Cancers Risks by Population and BRCA Mutation Location" @default.
• W3179036350 cites W1500137114 @default.
• W3179036350 cites W1588589870 @default.
• W3179036350 cites W1949962974 @default.
• W3179036350 cites W1965624666 @default.
• W3179036350 cites W1969693388 @default.
• W3179036350 cites W1970575758 @default.
• W3179036350 cites W1983423794 @default.
• W3179036350 cites W1988050977 @default.
• W3179036350 cites W1999273149 @default.
• W3179036350 cites W2001877789 @default.
• W3179036350 cites W2002561481 @default.
• W3179036350 cites W2007027102 @default.
• W3179036350 cites W2007770143 @default.
• W3179036350 cites W2008099192 @default.
• W3179036350 cites W2013344385 @default.
• W3179036350 cites W2025460005 @default.
• W3179036350 cites W2028682388 @default.
• W3179036350 cites W2029151927 @default.
• W3179036350 cites W2032346580 @default.
• W3179036350 cites W2035765556 @default.
• W3179036350 cites W2035801850 @default.
• W3179036350 cites W2039211343 @default.
• W3179036350 cites W2046207926 @default.
• W3179036350 cites W2052313990 @default.
• W3179036350 cites W2058064521 @default.
• W3179036350 cites W2058680273 @default.
• W3179036350 cites W2064497439 @default.
• W3179036350 cites W2065420818 @default.
• W3179036350 cites W2071194784 @default.
• W3179036350 cites W2086840280 @default.
• W3179036350 cites W2100322752 @default.
• W3179036350 cites W2109465247 @default.
• W3179036350 cites W2112211663 @default.
• W3179036350 cites W2115802526 @default.
• W3179036350 cites W2115957711 @default.
• W3179036350 cites W2126703127 @default.
• W3179036350 cites W2133401220 @default.
• W3179036350 cites W2135023031 @default.
• W3179036350 cites W2135525536 @default.
• W3179036350 cites W2137303400 @default.
• W3179036350 cites W2138785710 @default.
• W3179036350 cites W2139557430 @default.
• W3179036350 cites W2143924924 @default.
• W3179036350 cites W2148983297 @default.
• W3179036350 cites W2152217620 @default.
• W3179036350 cites W2153579158 @default.
• W3179036350 cites W2160475700 @default.
• W3179036350 cites W2161697947 @default.
• W3179036350 cites W2162954339 @default.
• W3179036350 cites W2167151613 @default.
• W3179036350 cites W2168880218 @default.
• W3179036350 cites W2169664141 @default.
• W3179036350 cites W2169862738 @default.
• W3179036350 cites W2170958906 @default.
• W3179036350 cites W2193183011 @default.
• W3179036350 cites W2218994245 @default.
• W3179036350 cites W2224210111 @default.
• W3179036350 cites W2291376595 @default.
• W3179036350 cites W2414821470 @default.
• W3179036350 cites W2466624553 @default.
• W3179036350 cites W2517269318 @default.
• W3179036350 cites W2578010562 @default.
• W3179036350 cites W2594404528 @default.
• W3179036350 cites W2627871710 @default.
• W3179036350 cites W2755888348 @default.
• W3179036350 cites W2766137080 @default.
• W3179036350 cites W2772419959 @default.
• W3179036350 cites W2800832130 @default.
• W3179036350 cites W2885135929 @default.
• W3179036350 cites W2886713202 @default.
• W3179036350 cites W2894727665 @default.
• W3179036350 cites W2912707510 @default.
• W3179036350 cites W2923700709 @default.
• W3179036350 cites W2953534996 @default.
• W3179036350 cites W2956105973 @default.
• W3179036350 cites W2999977444 @default.
• W3179036350 cites W3030923611 @default.
• W3179036350 cites W3036283854 @default.
• W3179036350 cites W3048053652 @default.
• W3179036350 cites W3118983547 @default.
• W3179036350 cites W3124119591 @default.
• W3179036350 cites W3133959868 @default.
• W3179036350 cites W3136330220 @default.
• W3179036350 cites W3158186713 @default.
• W3179036350 cites W3165166859 @default.
• W3179036350 cites W3165741753 @default.
• W3179036350 cites W3171097935 @default.
• W3179036350 doi "https://doi.org/10.3390/genes12071050" @default.
• W3179036350 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8303997" @default.
• W3179036350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34356066" @default.

• next