Matches in SemOpenAlex for { <https://semopenalex.org/work/W3179067619> ?p ?o ?g. }
- W3179067619 abstract "Abstract Early events in retrovirus transmission are determined by interactions between incoming viruses and frontline cells near entry sites. Despite their importance for retroviral pathogenesis, very little is known about these events. We developed a bioluminescence imaging (BLI)-guided multiscale imaging approach to study these events in vivo . Engineered murine leukemia reporter viruses allowed us to monitor individual stages of the retrovirus life cycle including virus particle flow, virus entry into cells, infection and spread for retroorbital, subcutaneous and oral routes. BLI permitted temporal tracking of orally administered retroviruses along the gastrointestinal tract as they traversed the lumen through Peyer’s Patch to reach the draining mesenteric sac. Importantly, capture and acquisition of lymph-, blood- and milk-borne retroviruses spanning three routes, was promoted by a common host factor, the I-type lectin CD169, expressed on sentinel macrophages. These results highlight how retroviruses co-opt the immune surveillance function of tissue resident sentinel macrophages for establishing infection." @default.
- W3179067619 created "2021-07-19" @default.
- W3179067619 creator A5010465089 @default.
- W3179067619 creator A5011918051 @default.
- W3179067619 creator A5017851734 @default.
- W3179067619 creator A5020111588 @default.
- W3179067619 creator A5025996219 @default.
- W3179067619 creator A5036684340 @default.
- W3179067619 creator A5037142999 @default.
- W3179067619 creator A5068857084 @default.
- W3179067619 creator A5076034595 @default.
- W3179067619 date "2020-10-20" @default.
- W3179067619 modified "2023-09-24" @default.
- W3179067619 title "In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission" @default.
- W3179067619 cites W1524929385 @default.
- W3179067619 cites W1532774876 @default.
- W3179067619 cites W1572769816 @default.
- W3179067619 cites W1855767215 @default.
- W3179067619 cites W1963355759 @default.
- W3179067619 cites W1965916060 @default.
- W3179067619 cites W1967856579 @default.
- W3179067619 cites W1969564240 @default.
- W3179067619 cites W1977144637 @default.
- W3179067619 cites W1978699642 @default.
- W3179067619 cites W1987021814 @default.
- W3179067619 cites W1997615822 @default.
- W3179067619 cites W2008471218 @default.
- W3179067619 cites W2009898112 @default.
- W3179067619 cites W2014958998 @default.
- W3179067619 cites W2019206924 @default.
- W3179067619 cites W2024235284 @default.
- W3179067619 cites W2035871823 @default.
- W3179067619 cites W2041774032 @default.
- W3179067619 cites W2044086145 @default.
- W3179067619 cites W2051103397 @default.
- W3179067619 cites W2051587879 @default.
- W3179067619 cites W2054287923 @default.
- W3179067619 cites W2057010147 @default.
- W3179067619 cites W2059265172 @default.
- W3179067619 cites W2062690397 @default.
- W3179067619 cites W2078489697 @default.
- W3179067619 cites W2088143327 @default.
- W3179067619 cites W2088747167 @default.
- W3179067619 cites W2092787543 @default.
- W3179067619 cites W2109590624 @default.
- W3179067619 cites W2110114546 @default.
- W3179067619 cites W2126371427 @default.
- W3179067619 cites W2139974970 @default.
- W3179067619 cites W2142161929 @default.
- W3179067619 cites W2147043831 @default.
- W3179067619 cites W2147880249 @default.
- W3179067619 cites W2148932927 @default.
- W3179067619 cites W2161358581 @default.
- W3179067619 cites W2162938388 @default.
- W3179067619 cites W2172179018 @default.
- W3179067619 cites W2178816986 @default.
- W3179067619 cites W2188634560 @default.
- W3179067619 cites W2403109086 @default.
- W3179067619 cites W2415046030 @default.
- W3179067619 cites W2487704570 @default.
- W3179067619 cites W2523136766 @default.
- W3179067619 cites W2592953665 @default.
- W3179067619 cites W2763279542 @default.
- W3179067619 cites W2785396374 @default.
- W3179067619 cites W2907881093 @default.
- W3179067619 cites W2949613316 @default.
- W3179067619 cites W2957390429 @default.
- W3179067619 cites W2969347678 @default.
- W3179067619 cites W2979790947 @default.
- W3179067619 cites W2994337438 @default.
- W3179067619 doi "https://doi.org/10.1101/2020.10.20.347427" @default.
- W3179067619 hasPublicationYear "2020" @default.
- W3179067619 type Work @default.
- W3179067619 sameAs 3179067619 @default.
- W3179067619 citedByCount "1" @default.
- W3179067619 countsByYear W31790676192020 @default.
- W3179067619 crossrefType "posted-content" @default.
- W3179067619 hasAuthorship W3179067619A5010465089 @default.
- W3179067619 hasAuthorship W3179067619A5011918051 @default.
- W3179067619 hasAuthorship W3179067619A5017851734 @default.
- W3179067619 hasAuthorship W3179067619A5020111588 @default.
- W3179067619 hasAuthorship W3179067619A5025996219 @default.
- W3179067619 hasAuthorship W3179067619A5036684340 @default.
- W3179067619 hasAuthorship W3179067619A5037142999 @default.
- W3179067619 hasAuthorship W3179067619A5068857084 @default.
- W3179067619 hasAuthorship W3179067619A5076034595 @default.
- W3179067619 hasBestOaLocation W31790676191 @default.
- W3179067619 hasConcept C111335760 @default.
- W3179067619 hasConcept C119599485 @default.
- W3179067619 hasConcept C127413603 @default.
- W3179067619 hasConcept C159047783 @default.
- W3179067619 hasConcept C161997846 @default.
- W3179067619 hasConcept C203014093 @default.
- W3179067619 hasConcept C207001950 @default.
- W3179067619 hasConcept C2522874641 @default.
- W3179067619 hasConcept C2778017598 @default.
- W3179067619 hasConcept C2778431562 @default.
- W3179067619 hasConcept C2779237934 @default.
- W3179067619 hasConcept C2780512811 @default.
- W3179067619 hasConcept C54009773 @default.