FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3179083089> ?p ?o ?g. }

• W3179083089 endingPage "7144" @default.
• W3179083089 startingPage "7144" @default.
• W3179083089 abstract "This Italian observational real-world study aims to assess in chronic hepatitis C virus (HCV) patients treated with pangenotypic direct acting agents (pDAAs) glecaprevir/pibrentasvir (GLE/PIB) or sofosbuvir/velpatasvir (SOF/VEL) the potential drug-drug interactions (DDIs) with concomitant medications prescribed, with a focus on cardiovascular and system nervous (CNS) co-medications. Data were collected from administrative databases covering 6.9 million health-assisted individuals. All patients prescribed SOF/VEL or GLE/PIB between 11/2017 and 12/2018 were included. Patients were analyzed while on DAA. DDIs were identified according to the Liverpool University tool. Overall, 3181 HCV patients were included: 1619 in the GLE/PIB cohort and 1562 in the SOF/VEL cohort. SOF/VEL patients were generally older than GLE/PIB ones (mean age 58.4 vs. 53.1, p < 0.001) and had more cardiovascular and CNS comorbidities (58% vs. 42%, p < 0.001 and 33% vs. 28%, p = 0.002, respectively). Contraindications due to DDIs in the GLE/PIB cohort affected 9.3% and 3.2% of patients before and on DAA, respectively, while the percentages in the SOF/VEL cohort were 3.2% before and 0.4% after pDAAs initiation. Among GLE/PIB patients, 2.7% had cardiovascular drugs (all statins) contraindicated while on DAA. The potential DDIs between cardiovascular drugs and SOF/VEL were mainly with statins (5%). SOF/VEL was prescribed in patients with older age and with more cardiovascular and CNS comorbidities. Despite this, a proportion of contraindicated drugs lower than that of GLE/PIB was registered." @default.
• W3179083089 created "2021-07-19" @default.
• W3179083089 creator A5003801571 @default.
• W3179083089 creator A5007585300 @default.
• W3179083089 creator A5013141366 @default.
• W3179083089 creator A5018438253 @default.
• W3179083089 creator A5021206943 @default.
• W3179083089 creator A5022470178 @default.
• W3179083089 creator A5053214629 @default.
• W3179083089 creator A5066445066 @default.
• W3179083089 creator A5072500126 @default.
• W3179083089 creator A5083761306 @default.
• W3179083089 creator A5086590936 @default.
• W3179083089 creator A5089189296 @default.
• W3179083089 date "2021-07-03" @default.
• W3179083089 modified "2023-10-18" @default.
• W3179083089 title "Drug–Drug Interactions in Italian Patients with Chronic Hepatitis C Treated with Pangenotypic Direct Acting Agents: Insights from a Real-World Study" @default.
• W3179083089 cites W2006805312 @default.
• W3179083089 cites W2241552982 @default.
• W3179083089 cites W2282334743 @default.
• W3179083089 cites W2443680666 @default.
• W3179083089 cites W2514340439 @default.
• W3179083089 cites W2517964493 @default.
• W3179083089 cites W2592128079 @default.
• W3179083089 cites W2610792433 @default.
• W3179083089 cites W2790788930 @default.
• W3179083089 cites W2791036494 @default.
• W3179083089 cites W2801776706 @default.
• W3179083089 cites W2891874109 @default.
• W3179083089 cites W2894210232 @default.
• W3179083089 cites W2906222391 @default.
• W3179083089 cites W2945873923 @default.
• W3179083089 cites W2965873285 @default.
• W3179083089 cites W2969539542 @default.
• W3179083089 cites W2973406008 @default.
• W3179083089 cites W2987708350 @default.
• W3179083089 cites W3005612827 @default.
• W3179083089 cites W3005839056 @default.
• W3179083089 cites W3027214204 @default.
• W3179083089 cites W3088020815 @default.
• W3179083089 cites W3094779369 @default.
• W3179083089 cites W3111542288 @default.
• W3179083089 doi "https://doi.org/10.3390/ijerph18137144" @default.
• W3179083089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8296917" @default.
• W3179083089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34281080" @default.
• W3179083089 hasPublicationYear "2021" @default.
• W3179083089 type Work @default.
• W3179083089 sameAs 3179083089 @default.
• W3179083089 citedByCount "9" @default.
• W3179083089 countsByYear W31790830892022 @default.
• W3179083089 countsByYear W31790830892023 @default.
• W3179083089 crossrefType "journal-article" @default.
• W3179083089 hasAuthorship W3179083089A5003801571 @default.
• W3179083089 hasAuthorship W3179083089A5007585300 @default.
• W3179083089 hasAuthorship W3179083089A5013141366 @default.
• W3179083089 hasAuthorship W3179083089A5018438253 @default.
• W3179083089 hasAuthorship W3179083089A5021206943 @default.
• W3179083089 hasAuthorship W3179083089A5022470178 @default.
• W3179083089 hasAuthorship W3179083089A5053214629 @default.
• W3179083089 hasAuthorship W3179083089A5066445066 @default.
• W3179083089 hasAuthorship W3179083089A5072500126 @default.
• W3179083089 hasAuthorship W3179083089A5083761306 @default.
• W3179083089 hasAuthorship W3179083089A5086590936 @default.
• W3179083089 hasAuthorship W3179083089A5089189296 @default.
• W3179083089 hasBestOaLocation W31790830891 @default.
• W3179083089 hasConcept C126322002 @default.
• W3179083089 hasConcept C201903717 @default.
• W3179083089 hasConcept C203014093 @default.
• W3179083089 hasConcept C2522874641 @default.
• W3179083089 hasConcept C2776408679 @default.
• W3179083089 hasConcept C2776455275 @default.
• W3179083089 hasConcept C2778390639 @default.
• W3179083089 hasConcept C2779384505 @default.
• W3179083089 hasConcept C2780035454 @default.
• W3179083089 hasConcept C2780040827 @default.
• W3179083089 hasConcept C71924100 @default.
• W3179083089 hasConcept C72563966 @default.
• W3179083089 hasConcept C98274493 @default.
• W3179083089 hasConceptScore W3179083089C126322002 @default.
• W3179083089 hasConceptScore W3179083089C201903717 @default.
• W3179083089 hasConceptScore W3179083089C203014093 @default.
• W3179083089 hasConceptScore W3179083089C2522874641 @default.
• W3179083089 hasConceptScore W3179083089C2776408679 @default.
• W3179083089 hasConceptScore W3179083089C2776455275 @default.
• W3179083089 hasConceptScore W3179083089C2778390639 @default.
• W3179083089 hasConceptScore W3179083089C2779384505 @default.
• W3179083089 hasConceptScore W3179083089C2780035454 @default.
• W3179083089 hasConceptScore W3179083089C2780040827 @default.
• W3179083089 hasConceptScore W3179083089C71924100 @default.
• W3179083089 hasConceptScore W3179083089C72563966 @default.
• W3179083089 hasConceptScore W3179083089C98274493 @default.
• W3179083089 hasIssue "13" @default.
• W3179083089 hasLocation W31790830891 @default.
• W3179083089 hasLocation W31790830892 @default.
• W3179083089 hasLocation W31790830893 @default.
• W3179083089 hasLocation W31790830894 @default.
• W3179083089 hasOpenAccess W3179083089 @default.
• W3179083089 hasPrimaryLocation W31790830891 @default.

• next