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- W3179272502 abstract "Here, the mechanism of hypoxia-inducible factor-α (HIF-α) regulation in acute kidney injury (AKI) was investigated. We found that tubular HIF-1α expression significantly increased at the transcriptional level, which was closely associated with macrophage-dependent inflammation. Meanwhile, NF-κB was involved in the increasing expression of HIF-1α in AKI. Mechanistically, NF-κB directly bound to the HIF-1α promoter and enhanced its transcription. Our findings not only provide novel insights into HIF-1 regulation in AKI but also offer to understand the pathophysiology of kidney diseases." @default.
- W3179272502 created "2021-07-19" @default.
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- W3179272502 date "2021-08-01" @default.
- W3179272502 modified "2023-10-14" @default.
- W3179272502 title "HIF-1α is transcriptionally regulated by NF-κB in acute kidney injury" @default.
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- W3179272502 doi "https://doi.org/10.1152/ajprenal.00119.2021" @default.
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