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• W3179458623 startingPage "122697" @default.
• W3179458623 abstract "The endogenous epigenetic marker 5-formylcytosine (5 fC) is introduced by 5-methylcytosine (5 mC) oxidation under action of enzyme oxidation, and plays an important role in many life activities. Since the content of 5 fC in mammalian tissues and cells is very low, it is necessary to exploit a sensitive and specific detection method to further understand the function of 5 fC. In this work, a sensitively and selectively photoelectrochemical (PEC) biosensor was developed for 5-formyl-2′-deoxycytidine (5fdC) detection. CuBi 2 O 4 /ZnPc@WS 2 was used as photoactive material, where the formed ternary heterojunction structure greatly enhanced the PEC response and increased the detection sensitivity. Positively charged polyethyleneimine (PEI) was employed as 5fdC recognition and capture unit, where the amine group on PEI specifically reacted with aldehyde group of 5fdC to form stable amide bond. 4-Carboxyphenylboronic acid (4-CPBA) was adopted as crosslinker for 5fdC and amino functionalized CuBi 2 O 4 based on the covalent interaction between 1,3-diol bond on 5fdC and boric acid structure on 4-CPBA, and the covalent interaction between –COOH on 4-CPBA and –NH 2 on amino functionalized CuBi 2 O 4 . On the basis of the positive synergistic effect of ZnPc and CuBi 2 O 4 on improving the photoelectric performance of WS 2 , the separation of photo-generated electron-hole pairs in semiconductors were promoted, and the examination range was expanded from 0.1 to 500 nM, and the detection limit was 0.0483 nM (3σ). Based on the unique covalent reaction between –NH 2 and –CHO, the PEC biosensor has excellent detection sensitivity, and can even separate 5fdC from 5-methylcytosine deoxyribonucleoside and 5-hydroxymethylcytosine deoxyribonucleoside. The effect of antibiotics and heavy metals on the 5fdC content in wheat tissue genome has also been further investigated using this sensor. • 5-formyl-2′-deoxycytidine (5fdC) was detected using photoelectrochemical method. • ZnPc@WS 2 composite was employed as photoactive material. • The detection signal was amplified by CuBi 2 O 4 , ZnPc and WS 2 ternary heterojunction. • The effects of antibiotics and heavy metals on 5fdC expression of 5fdC were investigated." @default.
• W3179458623 created "2021-07-19" @default.
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• W3179458623 date "2021-11-01" @default.
• W3179458623 modified "2023-10-14" @default.
• W3179458623 title "Enhanced photoactivity of ZnPc@WS2 heterojunction by CuBi2O4 and its application for photoelectrochemical detection of 5-formyl-2′-deoxycytidine" @default.
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• W3179458623 doi "https://doi.org/10.1016/j.talanta.2021.122697" @default.
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