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• W3179500035 abstract "Breast cancer stem cells (BCSCs) are drivers of therapy-resistance, therefore are responsible for poor survival. Molecular signatures of BCSCs from primary cancers remain undefined. Here, we identify the consistent transcriptome of primary BCSCs shared across breast cancer subtypes, and we examine the clinical relevance of ITGA7, one of the genes differentially expressed in BCSCs.Primary BCSCs were assessed using immunohistochemistry and fluorescently labelled using Aldefluor (n = 17). Transcriptomes of fluorescently sorted BCSCs and matched non-stem cancer cells were determined using RNA-seq (n = 6). ITGA7 expression was examined in breast cancers using immunohistochemistry (n = 305), and its functional role was tested using siRNA in breast cancer cells.Proportions of BCSCs varied from 0 to 9.4%. 38 genes were significantly differentially expressed in BCSCs; genes were enriched for functions in vessel morphogenesis, motility, and metabolism. ITGA7 was found to be significantly downregulated in BCSCs, and low expression significantly correlated with reduced survival in patients treated with chemotherapy, and with chemoresistance in breast cancer cells in vitro.This study is the first to define the molecular profile of BCSCs from a range of primary breast cancers. ITGA7 acts as a predictive marker for chemotherapy response, in accordance with its downregulation in BCSCs." @default.
• W3179500035 created "2021-07-19" @default.
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• W3179500035 date "2021-07-12" @default.
• W3179500035 modified "2023-10-07" @default.
• W3179500035 title "Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response" @default.
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• W3179500035 cites W1974466912 @default.
• W3179500035 cites W1979133628 @default.
• W3179500035 cites W1997280228 @default.
• W3179500035 cites W2010468255 @default.
• W3179500035 cites W2023316892 @default.
• W3179500035 cites W2023427658 @default.
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• W3179500035 cites W2167629024 @default.
• W3179500035 cites W2168853947 @default.
• W3179500035 cites W2173006562 @default.
• W3179500035 cites W2269332562 @default.
• W3179500035 cites W2292382041 @default.
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• W3179500035 doi "https://doi.org/10.1038/s41416-021-01484-w" @default.
• W3179500035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8476506" @default.
• W3179500035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34253873" @default.
• W3179500035 hasPublicationYear "2021" @default.
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