FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3179509718> ?p ?o ?g. }

• W3179509718 endingPage "668" @default.
• W3179509718 startingPage "668" @default.
• W3179509718 abstract "The strong psychoactive effects of synthetic cannabinoids raise the need for the deeper studying of their neurometabolic effects. The pharmacokinetic properties of 5F-APINAC and its influence on metabolomics profiles associated with neurotransmission were investigated in rabbit plasma. Twelve rabbits divided into three groups received 1-mL 5F-APINAC at 0.1, 1 and 2 mg/kg. The intervention groups were compared with the controls. Sampling was performed at nine time points (0–24 h). Ultra-high-performance liquid chromatography–tandem mass spectrometry was used. The pharmacokinetics were dose-dependent (higher curve at a higher dose) with a rapid biotransformation, followed by gradual elimination within 24 h. The tryptophan concentrations abruptly decreased (p < 0.05) in all tested groups, returning to the basal levels after 6 h. 5-hydroxylindole acetic acid increased (p < 0.05) in the controls, but this trend was absent in the treated groups. The aspartic acid concentrations were elevated (p < 0.001) in the treated groups. L-kynurenine was elevated (p < 0.01) in the intervention groups receiving 1 mg/kg to 2 mg/kg. Dose-dependent elevations (p < 0.01) were found for kynurenic acid, xanthurenic acid and quinolinic acid (p < 0.01), whereas the anthranilic acid trends were decreased (p < 0.01). The indole-3-propionic acid and indole-3-carboxaldehyde trends were elevated (p < 0.05), whereas the indole-3-lactic acid trajectories were decreased (p < 0.01) in the intervention groups. 5F-APINAC administration had a rapid biotransformation and gradual elimination. The metabolites related to the kynurenine and serotonergic system/serotonin pathways, aspartic acid innervation system and microbial tryptophan catabolism were altered." @default.
• W3179509718 created "2021-07-19" @default.
• W3179509718 creator A5000298447 @default.
• W3179509718 creator A5011135604 @default.
• W3179509718 creator A5017624762 @default.
• W3179509718 creator A5022602550 @default.
• W3179509718 creator A5025249324 @default.
• W3179509718 creator A5027496241 @default.
• W3179509718 creator A5044408743 @default.
• W3179509718 creator A5059129094 @default.
• W3179509718 creator A5066958563 @default.
• W3179509718 creator A5071390552 @default.
• W3179509718 creator A5072894623 @default.
• W3179509718 creator A5080110469 @default.
• W3179509718 creator A5082972362 @default.
• W3179509718 date "2021-07-13" @default.
• W3179509718 modified "2023-09-27" @default.
• W3179509718 title "Pharmacokinetic Properties of the Novel Synthetic Cannabinoid 5F-APINAC and Its Influence on Metabolites Associated with Neurotransmission in Rabbit Plasma" @default.
• W3179509718 cites W1546992055 @default.
• W3179509718 cites W1603819614 @default.
• W3179509718 cites W1916493178 @default.
• W3179509718 cites W1964475415 @default.
• W3179509718 cites W1969388943 @default.
• W3179509718 cites W1981095245 @default.
• W3179509718 cites W1983949227 @default.
• W3179509718 cites W2003527755 @default.
• W3179509718 cites W2005599435 @default.
• W3179509718 cites W2015910711 @default.
• W3179509718 cites W2026666148 @default.
• W3179509718 cites W2027187941 @default.
• W3179509718 cites W2057019886 @default.
• W3179509718 cites W2059197184 @default.
• W3179509718 cites W2061383340 @default.
• W3179509718 cites W2064701360 @default.
• W3179509718 cites W2070688712 @default.
• W3179509718 cites W2072398980 @default.
• W3179509718 cites W2075010970 @default.
• W3179509718 cites W2077344990 @default.
• W3179509718 cites W2112219780 @default.
• W3179509718 cites W2123495218 @default.
• W3179509718 cites W2131932927 @default.
• W3179509718 cites W2135892739 @default.
• W3179509718 cites W2137182040 @default.
• W3179509718 cites W2299985741 @default.
• W3179509718 cites W2422346997 @default.
• W3179509718 cites W2510451333 @default.
• W3179509718 cites W2586396224 @default.
• W3179509718 cites W2604754181 @default.
• W3179509718 cites W2607452034 @default.
• W3179509718 cites W2803960895 @default.
• W3179509718 cites W2807728333 @default.
• W3179509718 cites W2892544599 @default.
• W3179509718 cites W2919038148 @default.
• W3179509718 cites W2921491219 @default.
• W3179509718 cites W2946708385 @default.
• W3179509718 cites W2979306326 @default.
• W3179509718 cites W3009338814 @default.
• W3179509718 cites W3011521750 @default.
• W3179509718 cites W3035261227 @default.
• W3179509718 cites W3126945787 @default.
• W3179509718 doi "https://doi.org/10.3390/ph14070668" @default.
• W3179509718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8308683" @default.
• W3179509718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34358094" @default.
• W3179509718 hasPublicationYear "2021" @default.
• W3179509718 type Work @default.
• W3179509718 sameAs 3179509718 @default.
• W3179509718 citedByCount "3" @default.
• W3179509718 countsByYear W31795097182023 @default.
• W3179509718 crossrefType "journal-article" @default.
• W3179509718 hasAuthorship W3179509718A5000298447 @default.
• W3179509718 hasAuthorship W3179509718A5011135604 @default.
• W3179509718 hasAuthorship W3179509718A5017624762 @default.
• W3179509718 hasAuthorship W3179509718A5022602550 @default.
• W3179509718 hasAuthorship W3179509718A5025249324 @default.
• W3179509718 hasAuthorship W3179509718A5027496241 @default.
• W3179509718 hasAuthorship W3179509718A5044408743 @default.
• W3179509718 hasAuthorship W3179509718A5059129094 @default.
• W3179509718 hasAuthorship W3179509718A5066958563 @default.
• W3179509718 hasAuthorship W3179509718A5071390552 @default.
• W3179509718 hasAuthorship W3179509718A5072894623 @default.
• W3179509718 hasAuthorship W3179509718A5080110469 @default.
• W3179509718 hasAuthorship W3179509718A5082972362 @default.
• W3179509718 hasBestOaLocation W31795097181 @default.
• W3179509718 hasConcept C112705442 @default.
• W3179509718 hasConcept C126322002 @default.
• W3179509718 hasConcept C185592680 @default.
• W3179509718 hasConcept C2776706248 @default.
• W3179509718 hasConcept C2776841986 @default.
• W3179509718 hasConcept C2777477808 @default.
• W3179509718 hasConcept C2777503454 @default.
• W3179509718 hasConcept C2777896816 @default.
• W3179509718 hasConcept C2779187253 @default.
• W3179509718 hasConcept C2779816182 @default.
• W3179509718 hasConcept C515207424 @default.
• W3179509718 hasConcept C55493867 @default.
• W3179509718 hasConcept C71924100 @default.
• W3179509718 hasConcept C98274493 @default.
• W3179509718 hasConceptScore W3179509718C112705442 @default.

• next