Matches in SemOpenAlex for { <https://semopenalex.org/work/W3179548977> ?p ?o ?g. }
- W3179548977 endingPage "989" @default.
- W3179548977 startingPage "977" @default.
- W3179548977 abstract "Introduction: Noninfectious uveitis (NIU) is one of the leading causes of blindness worldwide. In adult patients, anterior NIU is usually managed with topical corticosteroids. In intermediate, posterior uveitis. and panuveitis, systemic corticosteroids are used especially in case of bilaterality or association with systemic disease. Biotherapies are recommended in case of inefficacy or intolerance to corticosteroids or conventional immunosuppressive drugs. Anti-TNF-α agents are by far the most widely used biotherapies. In case of failure or poor tolerance to anti-TNF-α, new targeted therapies can be proposed.Areas covered: We present and discuss an updated overview on biologics and biotherapies in NIU.Expert opinion: In case of dependency to systemic or intravitreal steroids, sight-threatening disease, and/or failure of conventional immunosuppressive drugs, anti-TNF-α are used as first-line biologics to achieve quiescence of inflammation. Anti-interleukin-6 is another option that may be proposed as first-line biologic or in case of poor efficacy of anti-TNF-α. Interferon can be directly proposed in specific indications (e.g. refractory macular edema, sight-threatening Behçet's uveitis). In the rare cases that remain unresponsive to traditional biotherapies, novel molecules, such as Janus-associated-kinase and anti-phosphodiesterase-4-inhibitors can be used. Therapeutic response must always be evaluated by clinical and appropriate ancillary investigations." @default.
- W3179548977 created "2021-07-19" @default.
- W3179548977 creator A5022140141 @default.
- W3179548977 creator A5024226918 @default.
- W3179548977 creator A5053346963 @default.
- W3179548977 creator A5064049236 @default.
- W3179548977 creator A5067370868 @default.
- W3179548977 creator A5085382022 @default.
- W3179548977 creator A5085912537 @default.
- W3179548977 creator A5086216178 @default.
- W3179548977 date "2021-07-26" @default.
- W3179548977 modified "2023-10-18" @default.
- W3179548977 title "Perspectives for immunotherapy in noninfectious immune mediated uveitis" @default.
- W3179548977 cites W1550772045 @default.
- W3179548977 cites W1931337664 @default.
- W3179548977 cites W1970956968 @default.
- W3179548977 cites W1973387000 @default.
- W3179548977 cites W1978813707 @default.
- W3179548977 cites W1982316939 @default.
- W3179548977 cites W1984733295 @default.
- W3179548977 cites W1986561345 @default.
- W3179548977 cites W1987000956 @default.
- W3179548977 cites W1989029085 @default.
- W3179548977 cites W1994056390 @default.
- W3179548977 cites W1995106708 @default.
- W3179548977 cites W1998677128 @default.
- W3179548977 cites W2018720535 @default.
- W3179548977 cites W2023774600 @default.
- W3179548977 cites W2043198160 @default.
- W3179548977 cites W2045074773 @default.
- W3179548977 cites W2045702785 @default.
- W3179548977 cites W2049584106 @default.
- W3179548977 cites W2055081569 @default.
- W3179548977 cites W2055913604 @default.
- W3179548977 cites W2067499731 @default.
- W3179548977 cites W2074736189 @default.
- W3179548977 cites W2077199006 @default.
- W3179548977 cites W2087716361 @default.
- W3179548977 cites W2096903378 @default.
- W3179548977 cites W2098396593 @default.
- W3179548977 cites W2119333176 @default.
- W3179548977 cites W2124257367 @default.
- W3179548977 cites W2134076733 @default.
- W3179548977 cites W2134293291 @default.
- W3179548977 cites W2135538342 @default.
- W3179548977 cites W2136811009 @default.
- W3179548977 cites W2142473469 @default.
- W3179548977 cites W2156308487 @default.
- W3179548977 cites W2157167110 @default.
- W3179548977 cites W2165626613 @default.
- W3179548977 cites W2222117171 @default.
- W3179548977 cites W2241409191 @default.
- W3179548977 cites W2278759026 @default.
- W3179548977 cites W2293474894 @default.
- W3179548977 cites W2302672524 @default.
- W3179548977 cites W2304411752 @default.
- W3179548977 cites W2464061075 @default.
- W3179548977 cites W2510021462 @default.
- W3179548977 cites W2511140591 @default.
- W3179548977 cites W2517470674 @default.
- W3179548977 cites W2531192107 @default.
- W3179548977 cites W2562844669 @default.
- W3179548977 cites W2593186219 @default.
- W3179548977 cites W2598849547 @default.
- W3179548977 cites W2607411827 @default.
- W3179548977 cites W2608059792 @default.
- W3179548977 cites W2608839610 @default.
- W3179548977 cites W2614732086 @default.
- W3179548977 cites W2740799220 @default.
- W3179548977 cites W2745842769 @default.
- W3179548977 cites W2750628707 @default.
- W3179548977 cites W2763598680 @default.
- W3179548977 cites W2786636081 @default.
- W3179548977 cites W2790599478 @default.
- W3179548977 cites W2790645197 @default.
- W3179548977 cites W2792515464 @default.
- W3179548977 cites W2811395636 @default.
- W3179548977 cites W2885763138 @default.
- W3179548977 cites W2896162934 @default.
- W3179548977 cites W2902598485 @default.
- W3179548977 cites W2908513563 @default.
- W3179548977 cites W2925057043 @default.
- W3179548977 cites W2945866604 @default.
- W3179548977 cites W2949295893 @default.
- W3179548977 cites W2953850901 @default.
- W3179548977 cites W2955879630 @default.
- W3179548977 cites W2965781575 @default.
- W3179548977 cites W2974088348 @default.
- W3179548977 cites W2980217501 @default.
- W3179548977 cites W2984666751 @default.
- W3179548977 cites W2992262947 @default.
- W3179548977 cites W2997360929 @default.
- W3179548977 cites W3004907187 @default.
- W3179548977 cites W3007278321 @default.
- W3179548977 cites W3017063723 @default.
- W3179548977 cites W3091327657 @default.
- W3179548977 cites W3091622094 @default.
- W3179548977 cites W3096568262 @default.