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- W3179564864 abstract "The study presented focuses on the role of the neuronal cell adhesion molecule L1 cell adhesion molecule (L1CAM) in retinoblastoma (RB), the most common malignant intraocular childhood tumor. L1CAM is differentially expressed in a variety of human cancers and has been suggested as a promising therapeutic target. We likewise observed differential expression patterns for L1CAM in RB cell lines and patient samples. The two proteases involved in ectodomain shedding of L1CAM (L1CAM sheddases: ADAM10 and ADAM17) were likewise differentially expressed in the RB cell lines investigated, and an involvement in L1CAM processing in RB cells could be verified. We also identified ezrin, galectin-3, and fibroblast growth factor basic as L1CAM signaling target genes in RB cells. Lentiviral L1CAM knockdown induced apoptosis and reduced cell viability, proliferation, growth, and colony formation capacity of RB cells, whereas L1CAM-overexpressing RB cells displayed the opposite effects. Chicken chorioallantoic membrane assays revealed that L1CAM depletion decreases the tumorigenic and migration potential of RB cells in vivo. Moreover, L1CAM depletion decreased viability and tumor growth of etoposide-resistant RB cell lines upon etoposide treatment in vitro and in vivo. Thus, L1CAM and its processing sheddases are potential novel targets for future therapeutic RB approaches." @default.
- W3179564864 created "2021-07-19" @default.
- W3179564864 creator A5002408786 @default.
- W3179564864 creator A5047405133 @default.
- W3179564864 creator A5059251744 @default.
- W3179564864 creator A5072359407 @default.
- W3179564864 date "2021-07-18" @default.
- W3179564864 modified "2023-10-17" @default.
- W3179564864 title "Role of L1CAM in retinoblastoma tumorigenesis: identification of novel therapeutic targets" @default.
- W3179564864 cites W1502740750 @default.
- W3179564864 cites W1519967758 @default.
- W3179564864 cites W1546966452 @default.
- W3179564864 cites W1604510112 @default.
- W3179564864 cites W1778442814 @default.
- W3179564864 cites W1819122594 @default.
- W3179564864 cites W1830240816 @default.
- W3179564864 cites W1903017783 @default.
- W3179564864 cites W1969224687 @default.
- W3179564864 cites W1969541160 @default.
- W3179564864 cites W1979760206 @default.
- W3179564864 cites W1983172399 @default.
- W3179564864 cites W1985789005 @default.
- W3179564864 cites W1990096652 @default.
- W3179564864 cites W1992660677 @default.
- W3179564864 cites W1997568015 @default.
- W3179564864 cites W2000006839 @default.
- W3179564864 cites W2004339436 @default.
- W3179564864 cites W2006220806 @default.
- W3179564864 cites W2007769575 @default.
- W3179564864 cites W2009914881 @default.
- W3179564864 cites W2010713632 @default.
- W3179564864 cites W2015243506 @default.
- W3179564864 cites W2017634417 @default.
- W3179564864 cites W2019009843 @default.
- W3179564864 cites W2019662547 @default.
- W3179564864 cites W2024148389 @default.
- W3179564864 cites W2029191719 @default.
- W3179564864 cites W2035107532 @default.
- W3179564864 cites W2045228092 @default.
- W3179564864 cites W2045881743 @default.
- W3179564864 cites W2047039315 @default.
- W3179564864 cites W2047404721 @default.
- W3179564864 cites W2056087352 @default.
- W3179564864 cites W2059333100 @default.
- W3179564864 cites W2061523585 @default.
- W3179564864 cites W2067628822 @default.
- W3179564864 cites W2068273123 @default.
- W3179564864 cites W2074999015 @default.
- W3179564864 cites W2075407237 @default.
- W3179564864 cites W2075860675 @default.
- W3179564864 cites W2078453145 @default.
- W3179564864 cites W2078828223 @default.
- W3179564864 cites W2079767760 @default.
- W3179564864 cites W2080185672 @default.
- W3179564864 cites W2081835397 @default.
- W3179564864 cites W2091760751 @default.
- W3179564864 cites W2097079963 @default.
- W3179564864 cites W2097787735 @default.
- W3179564864 cites W2100651747 @default.
- W3179564864 cites W2103994324 @default.
- W3179564864 cites W2111314225 @default.
- W3179564864 cites W2116347075 @default.
- W3179564864 cites W2117304271 @default.
- W3179564864 cites W2121787561 @default.
- W3179564864 cites W2122263758 @default.
- W3179564864 cites W2124929819 @default.
- W3179564864 cites W2129515932 @default.
- W3179564864 cites W2132780337 @default.
- W3179564864 cites W2133471442 @default.
- W3179564864 cites W2137447546 @default.
- W3179564864 cites W2137592112 @default.
- W3179564864 cites W2139030718 @default.
- W3179564864 cites W2142801414 @default.
- W3179564864 cites W2146601467 @default.
- W3179564864 cites W2149152049 @default.
- W3179564864 cites W2153544366 @default.
- W3179564864 cites W2155426534 @default.
- W3179564864 cites W2157155706 @default.
- W3179564864 cites W2157232932 @default.
- W3179564864 cites W2157521002 @default.
- W3179564864 cites W2157549466 @default.
- W3179564864 cites W2163173042 @default.
- W3179564864 cites W2163506769 @default.
- W3179564864 cites W2167619577 @default.
- W3179564864 cites W2169425052 @default.
- W3179564864 cites W2170725518 @default.
- W3179564864 cites W2170802361 @default.
- W3179564864 cites W2271332419 @default.
- W3179564864 cites W2397931275 @default.
- W3179564864 cites W2398601466 @default.
- W3179564864 cites W2503850107 @default.
- W3179564864 cites W2506418499 @default.
- W3179564864 cites W2514418815 @default.
- W3179564864 cites W2551479354 @default.
- W3179564864 cites W2570968120 @default.
- W3179564864 cites W2612273911 @default.
- W3179564864 cites W2736267104 @default.
- W3179564864 cites W2741017563 @default.