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- W3179571082 abstract "In addition to their role as antibody producing cells, B cells make a critical contribution to adaptive immune responses by functioning as professional antigen-presenting cells (APC). Distinctive features of B cells as APC include the expression of the B cell receptor (BCR) for antigen and regulated expression of HLA-DO. Here, we discuss recent progress in investigation of B cells as APC. We start with an update on the canonical MHC class II antigen presentation pathway in B cells and alternative pathways, including generation of extracellular vesicles. Turning to APC function, we highlight the roles of B cells as thymic APC, as APC for T follicular helper (TFH), as APC for CD4 memory T cells and as presenters of idiotypic BCR determinants. We also note recent examples that link B cell Ag-presentation to disease. Emerging evidence indicates that, in addition to unique features of B cells compared to other professional APC, there is appreciable heterogeneity among B cells, arising from, for example, B cell activation state or the microenvironment." @default.
- W3179571082 created "2021-07-19" @default.
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- W3179571082 creator A5013648604 @default.
- W3179571082 creator A5017327198 @default.
- W3179571082 creator A5073265735 @default.
- W3179571082 date "2021-06-01" @default.
- W3179571082 modified "2023-09-26" @default.
- W3179571082 title "New insights into B cells as antigen presenting cells" @default.
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- W3179571082 doi "https://doi.org/10.1016/j.coi.2021.06.003" @default.
- W3179571082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34242927" @default.
- W3179571082 hasPublicationYear "2021" @default.
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