FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3179629853> ?p ?o ?g. }

• W3179629853 endingPage "2809" @default.
• W3179629853 startingPage "2793" @default.
• W3179629853 abstract "Growth factor receptor-bound protein 2 (GRB2) is a trivalent adaptor protein and a key element in signal transduction. It interacts via its flanking nSH3 and cSH3 domains with the proline-rich domain (PRD) of the RAS activator SOS1 and via its central SH2 domain with phosphorylated tyrosine residues of receptor tyrosine kinases (RTKs; e.g. HER2). The elucidation of structural organization and mechanistic insights into GRB2 interactions, however, remain challenging due to their inherent flexibility. This study represents an important advance in our mechanistic understanding of how GRB2 links RTKs to SOS1. Accordingly, it can be proposed that (1) HER2 pYP-bound SH2 potentiates GRB2 SH3 domain interactions with SOS1 (an allosteric mechanism); (2) the SH2 domain blocks cSH3, enabling nSH3 to bind SOS1 first before cSH3 follows (an avidity-based mechanism); and (3) the allosteric behavior of cSH3 to other domains appears to be unidirectional, although there is an allosteric effect between the SH2 and SH3 domains." @default.
• W3179629853 created "2021-07-19" @default.
• W3179629853 creator A5000520886 @default.
• W3179629853 creator A5031757852 @default.
• W3179629853 creator A5043640420 @default.
• W3179629853 creator A5057675654 @default.
• W3179629853 creator A5059168727 @default.
• W3179629853 creator A5082546186 @default.
• W3179629853 creator A5088686091 @default.
• W3179629853 creator A5091520561 @default.
• W3179629853 date "2021-07-23" @default.
• W3179629853 modified "2023-10-14" @default.
• W3179629853 title "The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands" @default.
• W3179629853 cites W1542060836 @default.
• W3179629853 cites W1614661592 @default.
• W3179629853 cites W1704845487 @default.
• W3179629853 cites W1952405987 @default.
• W3179629853 cites W1960299898 @default.
• W3179629853 cites W1968461373 @default.
• W3179629853 cites W1969166917 @default.
• W3179629853 cites W1970481650 @default.
• W3179629853 cites W1971475788 @default.
• W3179629853 cites W1973400979 @default.
• W3179629853 cites W1980793279 @default.
• W3179629853 cites W1980981327 @default.
• W3179629853 cites W1981389934 @default.
• W3179629853 cites W1981872277 @default.
• W3179629853 cites W1985439299 @default.
• W3179629853 cites W1986925639 @default.
• W3179629853 cites W1988893103 @default.
• W3179629853 cites W1992488018 @default.
• W3179629853 cites W1993807543 @default.
• W3179629853 cites W1999824494 @default.
• W3179629853 cites W2007601206 @default.
• W3179629853 cites W2010558905 @default.
• W3179629853 cites W2020357919 @default.
• W3179629853 cites W2032109356 @default.
• W3179629853 cites W2033903396 @default.
• W3179629853 cites W2040098705 @default.
• W3179629853 cites W2043578693 @default.
• W3179629853 cites W2043601243 @default.
• W3179629853 cites W2047622589 @default.
• W3179629853 cites W2049682677 @default.
• W3179629853 cites W2053212304 @default.
• W3179629853 cites W2057603067 @default.
• W3179629853 cites W2058083313 @default.
• W3179629853 cites W2061677225 @default.
• W3179629853 cites W2062715451 @default.
• W3179629853 cites W2071222048 @default.
• W3179629853 cites W2071609712 @default.
• W3179629853 cites W2072208556 @default.
• W3179629853 cites W2074918348 @default.
• W3179629853 cites W2075104267 @default.
• W3179629853 cites W2088893144 @default.
• W3179629853 cites W2091848990 @default.
• W3179629853 cites W2093034516 @default.
• W3179629853 cites W2097615010 @default.
• W3179629853 cites W2112600835 @default.
• W3179629853 cites W2125272201 @default.
• W3179629853 cites W2134393172 @default.
• W3179629853 cites W2136860804 @default.
• W3179629853 cites W2139398765 @default.
• W3179629853 cites W2140919907 @default.
• W3179629853 cites W2147545102 @default.
• W3179629853 cites W2149136324 @default.
• W3179629853 cites W2164682544 @default.
• W3179629853 cites W2168428430 @default.
• W3179629853 cites W2170910759 @default.
• W3179629853 cites W2171750882 @default.
• W3179629853 cites W2172015700 @default.
• W3179629853 cites W2259523499 @default.
• W3179629853 cites W2311060264 @default.
• W3179629853 cites W238883907 @default.
• W3179629853 cites W2487238524 @default.
• W3179629853 cites W2498155094 @default.
• W3179629853 cites W2547741754 @default.
• W3179629853 cites W2586637063 @default.
• W3179629853 cites W2737930702 @default.
• W3179629853 cites W2755687768 @default.
• W3179629853 cites W2768556704 @default.
• W3179629853 cites W2795475717 @default.
• W3179629853 cites W2800984981 @default.
• W3179629853 cites W2948308017 @default.
• W3179629853 cites W3001579831 @default.
• W3179629853 cites W3013720734 @default.
• W3179629853 cites W3092229078 @default.
• W3179629853 cites W3133587783 @default.
• W3179629853 cites W630412611 @default.
• W3179629853 doi "https://doi.org/10.1042/bcj20210105" @default.
• W3179629853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34232285" @default.
• W3179629853 hasPublicationYear "2021" @default.
• W3179629853 type Work @default.
• W3179629853 sameAs 3179629853 @default.
• W3179629853 citedByCount "12" @default.
• W3179629853 countsByYear W31796298532021 @default.
• W3179629853 countsByYear W31796298532022 @default.
• W3179629853 countsByYear W31796298532023 @default.
• W3179629853 crossrefType "journal-article" @default.

• next